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1997 Fiscal Year Final Research Report Summary

Co-operative Research on Clinical Application and Functional Preservation of Heart and Heart-lung Transplantation

Research Project

Project/Area Number 07307015
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionUniversity of Tokyo

Principal Investigator

NAKAJIMA Jun  Universty of Tokyo Hospital Assistant Professor, 医学部・附属病院, 講師 (90188954)

Co-Investigator(Kenkyū-buntansha) ISOBE Mitsuaki  Shinshu University Hospital Associate Professor, 医学部(病), 助教授 (80176263)
TAKAMOTO Shin-ichi  University of Tokyo Hospital Professor, 医学部(病), 教授 (60137833)
MATSUDA Hikaru  Osaka University Hospital Professor, 医学部(病), 教授 (00028614)
FUJIMURA Shigefumi  Tohoku University, Institute Development, Aging and cancer Professor, 加齢医学研究所・呼吸器研究分野, 教授 (40006078)
TABAYASHI Koichi  Tohoku University Hospital Professor, 医学部(病), 教授 (90142942)
Project Period (FY) 1995 – 1997
KeywordsHeart Transp lantation / Organ transp lantation network / Graft atherosclerosis / Cardiomyoathy / Immunosuppression / gene transfer / donation / Cardiac xenotransplantation
Research Abstract

Kaihara investigated information Network System for multi organ sharing and more appropriate to implement required features than a classical main frame, especially the details about handling informations on inter net system. Matsuda investigated graft coronary atherosclerosis is preset in the first several days of transplantation. Tabayashi and Isobe reported ACE inhibitor, Angiotensin II receptor antagonist, cell cycle gene decoy and anti adhesion molecule prevent graft atherosclerosis. Sano investigated the donor heart Function harvested after 1 hour of warm cardiac arrest. Taira reported feasibility of hyaluronidase fo rtified cardioplegia. Koyanagi studied new immunosuppressive agent. Kawashima and Nakatani reported two endostage cardiomyopathy cases. They were successfully treated with left ventricular assist device and still alive after weaning of the device. Furuse, Takamoto, Nakajima investigated discordant xenoheart transplantation in infantile monkeys. Hujimura, Eguchi, Yada experimentally investigated lung preservation and immunosuppressive therapy.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Suzuki J et al: "Non muscle and smooth muscle myosin heavey chain expression in ryected cardiac allografts" Circulation. 94. 1118-1124 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Isbe M et al: "Acceptance of primary skin graft after troatmod wid anti intercelludac adhesion molecules and anti-leucecyte function associated outigons mmoclonal antibodiesinmice" Transplantation. 62. 411-413 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawauchi M et al: "Antigonicity of heart values and vessels:A primate heart transplant study." Transplant Proc. 28. 1824-1825 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki J et al: "Prevention of graft coronary atheros clerosis by antisanse cdk2 kinase oligo nucleotide" Nature Medicine. 3. 900-903 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sawa Y et al: "A norel strategy for myocardial protection using in vivo franefection of cis element ,'Decoy'against NFKB Binding Site" Circulation. 96. II-280-II-285 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakajima J et al: "Role of costimul atory molecules on airway epithelial alls acting as alliantigon-presonting cells" Transplant Proc. 29. 2297-2300 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki J et al: "Nonmuscle and smooth muscle myosin heavy chain expression in rejected cardiac allografts." Circulation. 94. 1118-1124 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Isobe M et al: "Acceptance of primary skin graft after treatment with anti intercellular adhesion molecule-1 and anti-leucocyte function associated antigen 1 monoclonal antibodies in mice" Transplantation. 62. 411-413 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawauchi M et al: "Antigenicity of heart valves and vessels : A primate heart transplant study" Transplant Proc. 28. 1824-1825 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki J et al: "Prevention of graft coronary atherosclerosis by antisense cdk2 kinase oligonucleotide" Nature Medicine. 3. 900-903 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sawa Y et al: "A novel strategy for myocardial protection using in vivo transfection of cis element 'Decoy' against NFKB binding site" Circulation. 96. II-280-II-285 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakajima J et al: "Role of costimulatory molecules on airway epithelial cells acting as alloantigen presenting cells" Transplant Proc. 29. 2297-2300 (1997)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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