• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1996 Fiscal Year Final Research Report Summary

Development of neurobehavioral methods in occupational and environmental health and application of them to neurological, psychological and behavioral disorders.

Research Project

Project/Area Number 07307029
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section総合
Research Field Public health/Health science
Research InstitutionUniversity of Tokyo

Principal Investigator

ARAKI Shunichi  University of Tokyo, School of Medicine, Professor, 大学院・医学系研究科, 教授 (00111493)

Co-Investigator(Kenkyū-buntansha) KAWAKAMI Norito  Gifu University, School of Medicine, Associate Professor, 医学部, 助教授 (90177650)
KOBAYASHI Fumio  Aichi Medical University, School of Medicine, Professor, 医学部, 教授 (80135342)
KISHI Reiko  Hokkaido University, School of Medicine, Professor, 医学部, 教授 (80112449)
IGISU Hideki  University of Occupatioal and Environmental Health, Institute of Industrial Ecol, 産業生態科学研究所, 教授 (60108686)
TAKEUCHI Yasuhiro  Nagoya University School of Medicine, Professor, 医学部, 教授 (90022805)
Project Period (FY) 1995 – 1996
KeywordsOccupational and environmental health / neurobehavioral disorders / neurophysiological methods / neurochemical markers / neurobehavioral test battery / Imaging / Psychosocial factors / Molecular biology / 分子生物学的方法
Research Abstract

The study was conducted through collaboration of members of the Japanese Society for Industrial Health and Japanese Society of Behavioral Medicine, who belonged to several independent institutions, aiming at establishing neurobehavioral methods and at promotingresearches on neurological, psychological and behavioral disorders in occupational and environmental health. Focus of the study was as follows :
1.To establish sensitive and reliable methods which are feasible for studies in preventive medicine, in relation to new topics on the methodology of neurobehavioral research in occupational and environmental health, viz.neurophysiology, neurobehavioral test battery, imaging techniques, neurochemical markers, molecular biology, psycho-social factors, and behavioral medicine.
2.To identify subclinical neurological, psychological and behavioral effects of wide variety of occupational and environmental factors and establish their dose-effects relationships, using the above new methods.
3.To clarify risk factors of major occupational and environmental disorders such as neurotoxic diseases, work-related diseases including stress disorders and "life-style disease" and preventive strategies for them.
As a result, original and review papers, oral and poster presentations at international and national meetings, and monographs were made as listed in the research report attached, of which 31 papers are reproduced in the book.

  • Research Products

    (60 results)

All Other

All Publications (60 results)

  • [Publications] Murata,K.: "Subclinical impairment in the median nerve across the carpal tunnel among female VDT operators" International Archives of Occupational and Environmental Health. 68. 75-79 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fujmura,Y.: "Changes in the distribution of nerve conduction velocities in diabetics" Tohoku Journal of Experimental Medicine. 178. 177-185 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tanigawa,T.: "Decreases in subpopulations of lymphocytes and natural killer cells in the blood of retired chromate worker" International Journal of Occupational and Environmental Health. 2. 222-225 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tanigawa,T.: "Increase in CD57+CD16-lymphocytes in workers exposed to benzidine and beta-naphtylamine" International Archives of Occupational and Environmental Health. 69. 69-72 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tamiya,N.: "Gender difference in the utilization and user's characteristics of community rehabilitation programs for cerebrovasculardisease patients in Japan" International Journal for Quality in Health Care. 8. 359-366 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yokoyama,K.: "Subsclinical vestibulo-cerebellar,anterior cerebellar lobe and spinocerebellar effects in lead workers in relation to concurrent and past exposure" Neurotoxicology. 18. 371-380 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawakami,N.: "Effects of job strain on helper-inducer (CD4+CD29+) and suppress-inducer (CD4+CD45RA+) T cells in Japanese blue-collar workers" Psychother Psychosom. 66. 192-198 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakata,A.: "Effects of uncontrollable and controllable electric shocks" Nouroimmunomodulation. 3. 336-341 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Araki,S: "Neurophysiological methods in occupational and environmental health" Environmental Research. 73. 42-51 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Araki,S.: "Biobehavioral approach in occupational,environmental and community Health" Journal of Epidemiology. 6(suppl). S79-88 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kamijma, Takeuchi Y et al: "Toxic effects of hexane derivatives on cultured rat schurarn cells." Toxicol. 108巻. 25-31 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Aiba I, Takeuchi et al: "Changes in magnetic resonance imaging and clinical signs in a case of chronic toluene intoxicetion by sniffing" J Occur Health. 38巻. 13-19 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawakami N,et al.: "A controlled study on effects of a work environment-oriented stress reduction on depressive symptoms in Japanese blue-collar works." Scandinavian Journal of Work Environment and Health. 23. 54-59 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawakami N,et al.: "Occupational factors,smoking habits and tobacco withdrawal symptoms among male Japanese employees." Industrial Health. 35. 9-15 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawakami N,et al.: "Prevalence of mood and anxiety disorders in a working population in Japan." Journal of Occupational and Environmental Medicine. 38. 899-905 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Aoki R,et al.: "Life style determinants for social activity levels among the Japanese elderly" Archives of Gerontology and Geriatrics. 22. 261-269 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawakami N,et al.: "Reliability and validity of the Japanese version of Job Content Questionnaire replication and extension in computer company employees." Industrial Health. 34. 295-306 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kishi,R.: "Effect of prenatal exposur to styrene on the neurobehavioral development,activit,metor co-ordination and learning behavior" Neurotoxicology and teratology. 17-2. 121-130 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shibata E, Takeuchi Y et al: "Digital nerve conduction nelo citics et workers exposed to hevane and toluene." Arch Complex Environ Studies. 7巻. 47-49 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kondo H, Takeuchi Y et al: "Toluene induces behavioral activation without effecting striatal dopamine metabalism in the rat : selaciocal and miorodiabysis studies." Pharmacol Biochem Behav. 51巻. 97-101 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsuoka M, Matsumura H, Igisu H: "Creatine kinase activities in brain and blood : possible neurotoxic indicator of acrylamide intoxication" Occupational and Environmental Medicine. 53・7. 468-471 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsuoka M, Igisu H: "Induction of c-fos expression by tributyltin in PC12 cells : involvement of intracellular Ca^<2+>" Environmental Toxicology and Pharmacology. 2. 273-380 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsumura H, Matsuoka M, Igisu H, Ikeda M: "Cooperative inhibition of acetylcholinesterase activities by hexachlorophene in human erythrocytes" Archives of Toxicology. 71. 151-156 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Xu Z, Iryo Y, Matsuoka M, Igisu H,Ikeda M: "Suppression of pentylenetetrazol-induced seizures by carnitine in mice" Naunyn-Schmiedebergs Archives of Pharmacology. 355. 545-549 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Eguchi,T., Kishi,R.: "Impaired colour discrimination among workers exposed to styrent relavance of a urinary metabolite" Occupational and Environmental Medicine. 52. 534-538 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yuasa,J., Kishi,R.: "Investigation on neurotoxicity of occupational exposureto to cyclomexane : a neurophysiological study" Occupational and Environmental Medicine. 53. 174-179 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 湯浅潤子, 岸玲子, 原渕泉, 江口照子, 荒田吉彦,他: "末梢神経伝導速度への年齢および皮膚温の影響 職業製曝露作業者の神経機能評価のための基礎的研究" 産衛誌. 38巻. 158-164 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yuasa J, Kishi R, Eguchi T, Harabuchi I, Arata Y,et al: "Study of urinary Mandelic Acid Concentration and Periphere Nerve Conduction Among Styrene Workers" AMERICAN JOURNAL OF INDUSTRIAL MEDICINE. 30巻. 41-47 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岸 玲子: "化学物質曝露と精神保健-有機溶剤による影響を中心に-" 産業精神保健. 4巻3号. 208-216 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] WHO Task Group member (Araki,S.): "Inorganic Lead (Environmental Health Criteria 165)" World Health Organization,Geneva,Switzerland, 300 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 荒記 俊一: "'95医学と工学からみた交通安全対策 視認性と安全" 日本交通医学工学研究会, 39-43 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 荒記 俊一: "第3回中国人間工学会学術会議および運転適性に関する神経行動学国際会議論文集" 安徽人民出版社、(合肥、中国), 824-864 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Araki,S.: "Report of The Sixth Coordination Meeting of WHO Qlaborating Centers in Radiation Emergency Medical Preparedness and Assistance Network (REMPAN)" World Health Organization,Geneva,Switzerland, 182-202 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 荒記俊一: "職場環境 新版保健学講座" メヂカルフレンド社, 148-181 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 荒記俊一: "作業関連疾患予防マニュアル作成委員会報告書" 中央労働災害防止協会, 142-164 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Araki, S.: "Assessment of central, peripheral and autonomic nervous system functions in vibrating tool operators : neuroelectrophysiological studies" Environmental Research. 62. 272-282 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawakami, N.: "Relations of work stress to alcohol use and drinking problems in male and female employees of a computer factory in japan" Environmental Research. 62. 314-324 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Araki, S.: "Assessment of the effects of occupational and environmental factors on all faster and slower large myelinated nerve fibers : a study of the distribution of nerve conduction velocities" Environmental Research. 62. 325-332 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sata, F.: "Are faster or slower large myelinated nerve fibers more sensitive to chronic lead exposure? : a study of the distribution of conduction velocities" Environmental Research. 62. 333-338 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Araki, S.: "Decrease of CD4-positive T lymphocytes in workers exposed to benzidine and beta-naphthylamine" Archives of Environmental Health. 48(4). 205-208 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uchida, E.: "Scioeconomic factors affecting marriage, divorce and birth rates in japanese population" J Biosoc Sci. 25. 499-507 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ezoe, S.: "Work stress in japanese computer engineers : effcts of computer work or bioeducational factors?" Environmental Research. 63. 148-156 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murata, K.: "Cardiac autonomic dysfunction in rotogravure printers exposed to toluene in relation to peripheral nerve conduction" Industrial Health. 31. 79-90 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ezoe, S.: "Assessment of personality traits and psychiatric symptoms in workers in a computer manufacturing plant in japan" American Journal of Industrial Medicine. 25. 187-196 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murata, K.: "Autonomic neurotoxicity of alcohol assessed by heart rate variability" Journal of the Autonomic Nervous System. 48. 105-111 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murata, K.: "Changes in autonomic function as determined by ECG R-R interval variability in sandal, shoe, and leather workers exposed to n-hexane, xylene, and toluene" Neuro Toxicology. 15(4). 867-876 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Morita, Y.: "Determination of delta-aminolevulinic acid in plasma using high-performance liquid chromatography : a sensitive indicator of lead effects" Industrial Health. 32. 85-96 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tanigawa, T.: "Decreases of CD4- and CD8-positive T lymphocytes in retired chromate workers" American Journal of Industrial Medicine. 27. 877-882 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murata, K.: "Autonomic and central nervous system effects of lead in female glass workers in china" American Journal of Industrial Medicine. 28. 233-244 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sung, H,L.: "Selective decrease of the suppressor-inducer (CD4+CD45RA+) T lymphocytes in workers exposed to benzidine and beta-naphthylamine" Archives of Environmental Health. 50(3). 196-199 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawagami, N.: "Effects of mood states, smoking and urinary catecholamine excretion on hemoglobin Alc in male japanese workers" Industrial Health. 33. 153-162 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Wang, X.: "Effects of smoking on respiratory function and exercise performance in asbestos workers" Industrial Health. 33. 173-180 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawagami, N.: "Changes in rates of depressive symptoms in a japanese working population : life-table analysis from a 4-year follow-up study" Psychological Medicine. 25. 1181-1190 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sata, F.: "Adjustment of creatinine-adjusted values in urine to urinary flow rate : a study of eleven heavy metals and organic substances" Int Arch Occup Environ Health. 68. 64-68 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawagami, N.: "Assessment of job stress dimensions based on the job demonds-control model of employees of telecommunication and electric power companies in japan : reliability and validity of the japanese version of the job content questionnaire" International Journal of Behavioral Medicine. 2(4). 358-375 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murata, K.: "Subclinical impairment in the median nerve across the carpal tunnel among female VDT operators" Int Arch Occup Environ Health. 68. 75-79 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murata, K.: "Accumulation of VDT work-related visual fatigue assessed by visual evoked potential, near point distance and critical flicker fusion" Industrial Health. 34. 61-69 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujimura, Y.: "Changes in the distribution of nerve conduction velocities in diabetics" Tohoku J Exp Med. 178. 177-185 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Araki, S.: "Determination of evoked potentials in occupational and environmental medicine : a review" Environmental Research. 63. 133-147 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Araki, S.: "Application of neurophysiological methods in occupational medicine in relation to psychological performance" Annals Academy of Medicine. 23. 710-718 (1994)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1999-03-16  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi