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1996 Fiscal Year Final Research Report Summary

Design and Evaluation of Novel Selenium-Containing Antioxidant

Research Project

Project/Area Number 07455352
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 有機工業化学
Research InstitutionUniversity of Tokyo

Principal Investigator

NIKI Etsuo  University of Tokyo, Research Center for Advanced Science and Technology, Professor, 先端科学技術センター, 教授 (20011033)

Co-Investigator(Kenkyū-buntansha) NOGUCHI Noriko  University of Tokyo, Research Center for Advanced Science and Technology, Resear, 先端科学技術センター, 助手 (40198578)
YAMAMOTO Yorihiro  University of Tokyo, Research Center for Advanced Science and Technology, Associ, 先端科学技術センター, 助教授 (60134475)
Project Period (FY) 1995 – 1996
Keywordsantioxidant / lipid peroxidation / free radical / oxidative damage / selenium / peroxide / ebselen
Research Abstract

There is now increasing evidence which shows that the free-radical mediated oxidations proceed in vivo as in plastics rubber and lipids and that they play a causative role in the progression of various diseases, cancer and aging. As a consequence, the inhibition of such oxidations and development of novel potent antioxidants have received much attention. The present research has been carried out aiming at developing a novel selenium-containing antioxidant and evaluating its antioxidant potency. Ebselen, 2-phenyl-1,2-benzisoselenazol-3 (2H) -one, was chosen as a candidate and its antioxidant action and activity were studied. It was confirmed that ebselen did not act as a radical scavenger nor did it reduce vitamin E radical to regenerate vitamin E.Ebselen reduced hydroperoxides rapidly to corresponding alcohol and thereby inhibited the metal-catalyzed oxidations of lipids and low density lipoproteins. Furthermore, it was found that ebselen completely inhibited the lipid oxidation induce by lipoxygenase. Ebselen also exerted potent antioxidant activity against lipid peroxidation induced by peroxynitrite. It was concluded that ebselen is a potent antioxidant against oxidations induced by metal ions and peroxynitrite.

  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] Y.Yamamoto,et al.: "Antioxidant activity of 3-methyl-1-phenyl-2-pyrazolin-5-one(MCI-186)" Redox Report. 2. 333-338 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Yamamoto,Y.Nagata: "Oxidation of human plasma initiated with water-and lipid-soluble radical initiators." J.Jpn.Oil Chem.Soc.45. 445-452 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Sakai,Y.Yamamoto,et al.: "Phospholipase A_2 activity in non-glycated and glycated low density lipoproteins." Biochim.Biophys.Acta. 1301. 85-89 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Yamamoto,Y.Nagata,et al.: "Rat plasma free fatty acids composition under oxidative stress induced by carbon tetrachloride:decrease of polyunsaturated fatty acids and increase of palmitolec acid" Redox Report. 2. 121-125 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Noguchi,H.Sakai,et al.: "Inhibition of oxidation low density lipoprotein by troglitazone." Atherosclerosis. 123. 227-234 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Nagata,Y.Yamamoto,et al.: "Reaction of phosphatidylcholine hydroperoxide inhuman plasma:The role of peroxidase and lecithin:Cholesterol acyltransferase." Arch.Biochem.Biophys.329. 24-30 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 山本順寛: "フリーラジカルと臨床" 日本医学館,東京, 102 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] E.Niki,M.Oikawa,M.Takahashi: "Free Radicals in Brain Physiology and Disorders" Academic Press,San Diego,CA., 474 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Nagata, Y.Yamamoto, and E.Niki: "Reaction of phosphatidylcholin hydroperoxide inhuman plasma : The role of peroxidase and lecithin : Cholesterol acyltrandferase." Arch.Biochem.Biophys.329. 24-30 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Urakami, K.Sugamura, and E.Niki: "Characterization of imidazophyrroloquinoline compounds synthesized from coenzyme PQQ and various amino acids." BioFactors. 5. 75-81 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Noguchi, H.Sakai, Y.Kato, J.Tsuchiya, Y.Yamamoto, E.Niki, and H.Horikoshi: "Inhibition of oxidation low density lipoprotein by troglitazone." Atherosclerosis. 123. 227-234 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Urakami, A.Tanana, T.Tanimoto, E.Niki: "Synthesis and aldose reductase-inhibitory activity of imidazophyrroloquinoline esters." Chem.Pharm.Bull.44. 1493-1497 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Sakai, Y.Yamamoto, N.Baba, and M.Nakano: "Phospholipase A_2 activity in non-glycated and glycated low density lipoproteins." Biochim.Biophys.Acta. 1301. 85-89 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Yamamoto and Y.Nagata: "Oxidation of human plasma initiated with water- and lipid-soluble radical initiators." J.Jpn.Oil Chem.Soc.45. 445-452 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Yamamoto, T.Kuwahara, K.Watanabe, and K.Watanabe: "Antioxidant activity of 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186)" Redox Report. 2. 333-338 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Urakami, A.Tanaka, K.Yamaguchi, T.Tsuji, and E.Niki: "Synthesis of esters of coenzyme PQQ and IPQ,and stimulation of nerve growth factor production." BioFactors. 5. 139-146 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Urakami, C.Yoshida, T.Akaike, H.Maeda, H.Nishigori, and E.Niki: "Synthesis of monoesters of pyrroloquinoline quinone and imidazopyrroloquinoline, and radical scavenging activities using electron spin resonance in vitro and pharmacological activity in vivo." J.Nutr.Sci.Vitaminol.43. 19-23 (1997)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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