1997 Fiscal Year Final Research Report Summary
Novel enteric nerve plexus links enteric endocrine system with gastrointestinal motility
| Project/Area Number |
07457004
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Nagoya University |
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Principal Investigator |
TORIHASHI Shigeko Nagoya University, Dept.of Anatomy, Assistant Professor, 医学部, 助手 (90112961)
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| Co-Investigator(Kenkyū-buntansha) |
IINO Satoshi Nagoya University, Dept.of Anatomy, Assistant Professor, 医学部, 助手 (40242854)
SENDA Takao Nagoya University, Dept.of Anatomy, Associate Professor, 医学部, 助教授 (10187875)
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| Project Period (FY) |
1995 – 1997
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| Keywords | Gastrointestinal tract / Endocline system / Enteric nervous system / Pacemaker / c-kit / Sponteneous contraction / APC / Calcium binding protein |
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| Research Abstract |
The main purpose of this research was as follows ;
1) Identification of pacemaker cells of the spontaneous muscle contractions. 2) Analysis of the enteric nervous system which control spontaneous contractions. 3) Contractile response to the stimulation of the mucosa.
We obtained four research results.
1) Pacemaker cells were located at the submucosal surface of the colonic circular muscle layr in the dog, Guinea-pig and the mouse. They were a kind of special smooth muscle cells.
2) Pacemaker cells expressed c-kit receptor tyrosine kinase immunoreactivity and their development depended on c-kit signaling pathway.
3) Some enteric neurons expressed immunoreactivity of neurocalcin which is a neuuron specific calcium binding protein. Afferent nerve ending originated from vagus also expressed neurocalcin immunoreactivity
4) The tumor suppressor gene APC was expressed on the mucosa of the colon. The products of APC were co-localized with beta catenin and with DLG.It may be involved in the proliferation and differentiation of mucosal epithelial cells.
This research project was started by S.kobayashi as a head investigator from 1995 and after his death. S.Torihashi continued and completed.
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[Publications] Satoh K,Yanai H,Senda T,Kohu k, Nakamura T,Okumura N,Matsumine A,Kobayashi S,Toyoshima K,Akiyama T: "DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95." Genes to Cells. 2. 415-424 (1997)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Igakura T,Kadomatsu K,Kaname T,Muramatsu H,Fan Q-W,Miyauchi T,Toyama Y,Kuno N,Yuasa S,Takahashi M,Senda T,Taguchi O,Yamamura K,Arimura K,Muramatsu T: "A null mutation in basigin, an immunoglobulin superfamily member, indicates its important roles in periimplantation development and spermatogenesis." Dev Biol. (in press).
Description
「研究成果報告書概要(欧文)」より
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