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1997 Fiscal Year Final Research Report Summary

APPLICATION OF MONOCLONAL ANTIBODY FOR THE NEW TREATMENT AND DIAGNOSIS OF DIGESTIVE CANCER.

Research Project

Project/Area Number 07457277
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionKYOTO PREFECTURAL UNIVERSITY OF MEDICINE

Principal Investigator

TAKAHASHI Toshio  KYOTO PREFECTURAL UNIVERSITY OF MEDICINE,PROFESSOR, 医学部, 教授 (50079828)

Co-Investigator(Kenkyū-buntansha) OTSUJI Eigo  KYOTO PREFECTURAL UNIVERSITY OF MEDICINE,ASSISTANT PROFESSOR, 医学部, 助手 (20244600)
KITAMURA Kazuya  KYOTO PREFECTURAL UNIVERSITY OF MEDICINE,ASSISTANT PROFESSOR, 医学部, 助手 (10224966)
YAMAGUCHI Toshiharu  KYOTO PREFECTURAL UNIVERSITY OF MEDICINE,ASSOCIATE PROFESSOR, 医学部, 助教授 (90111327)
Project Period (FY) 1995 – 1997
KeywordsDIGESTIVE CANCER / MONOCLONAL ANTIBODY / CHIMERIC ANTIBODY / MICRO-FERRITE
Research Abstract

Huma/mouse chmeric antibody had been developed and anti-cancer drug neocarzinostatin could be bound with Fab fragment of chiemric antibody without loosing both anticancer and antibody activites. Clinical phase 1 study had been carried out and no seriouse adverse effects had been observed up to 40,000 units of immunoconojugates. The production of human anti-mouse antibody (HAMA) had been strongly suppressed in patients receiving chimeric antibody compared with patients receiving mouse immunocojugates.
Fine ferromagnetics had been successfully conojugated with antibody. The stability and capacity of the cojugates to bind with target cancer cell had been well preserved. The imaging of tumor tissue in experimental animal suggested its usefullness in MRI imaging in vivo. This new ferromagnetic immunoconjugate could be applied for ferro-immuno-guided surgery in the near future.

  • Research Products

    (53 results)

All Other

All Publications (53 results)

  • [Publications] 山口 俊晴: "抗体による癌治療" Surgery Frontier. 4(2). 82-86 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 山口 俊晴: "モノクローナル抗体による大腸癌の診断" 総合臨床. 46(2). 282-286 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 山口 俊晴: "胃癌の遺伝子診断" 外科. 59. 937-941 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 大辻 英吾: "ビオチン化抗体結合制癌剤とアビジンとによる副作用の少ない膵癌ミサイル療法の開発" Biotherapy. 11. 95-99 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 大辻 英吾: "キメラ化A7-Fab分画結合Neocarzinostatinの膵癌ミサイル療法への有用性" 癌と化学療法. 24. 2285-2287 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 山口 俊晴: "モノクローナル抗体結合抗癌薬による癌ミサイル療法" 医学のあゆみ. 184. 325-328 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] C.Sakakura: "Overexpression of Bax Sensitizes Breast Cancer MCF-7 Cells to Cisplatin and Etoposide" Surgery Today. 27. 676-679 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] C.Sakakura: "Overexpression of bax Enhances the Radiation Sensitivity in Human Breast Cancer Cells" Surgery Today. 27. 90-93 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] C.Sakakura: "Increased Apoptosis Rate by Hyperthermochemo radiotheraphy for Advanced Rectal Cancers" Surgery Today. 27. 773-776 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] E.Otsuji: "Decreased Renal Accumulation of Biotinylated Chimeric Monoclonal Antibody-Neocarzinostatin Conjugate after Administration of Avidin" Jpn.J.Cancer Res.88. 205-212 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Nish: "Reduced blood accumulation of biotinylated monoclonal antibody a7 after the subsequent administration of avidin" Cancer Letters. 120. 127-134 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 高橋 俊雄: "独創による外科の変革をめざして" 日本外科学会雑誌. 98(9). 789-793 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Takahashi: "Treatment of digestive cancer and its resulte, Progress in the diagnosis and treatment of cancer" 180-189 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Yamaguchi, T.Takahashi, K.Kitamura, E.Otsuji: "Missile therapy of cancer-Its future and problem-" Current Therapy. 13(5). 160-164 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Yamaguchi, T.Takahashi, K.Kitamura, E.Otsuji, M.Kato, Y.Yata, K.Okamaoto, H.Nishi, H.Tsuruta: "New development of the treatment of digestive cancer- Targeting therapy with chimeric antibody." Digestive Cancer. 5(5). 399-402 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Yamaguchi, K.Kitamura, E.Otsuji, K.Okamoto, H.Tsuruta, T.Takahashi: "Missile therapy of cancer" Ketsueki Syuyouka. 34(4). 332-338 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Yamaguchi, T.Takahashi: "Missile therapy of cancer." Rinsho Sanfujinnka. 49(7). 864-867 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E.Otsuji, T.Yamaguchi, N.Yamaoka, T.Kotani, M.Kato, K.Taniguchi, K.Kitamura, T.Takahashi: "Biodistribution of murine and chimeric Fab fragments of the monoclonal antibody A7 in human pancreatic cancer" Pancreas. 10(3). 265-273 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E.Otsuji, T.Yamaguchi, T.Kodama, T.Takahashi: "Application of monoclonal antibodies to histologic diagnosis of gastric cancers" Tohoku J.Exp.Med.176(4). 213-218 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E.Otsuji, T.Yamaguchi, T.Tsuruta, T.Yata, H.Nishi, K.Okamoto, K.Taniguchi, M.Kato, T.Kotani, K.Kitamura, T.Takahashi: "The effect of intravenous and intratumoural chemotherapy using a monoclonal antibody-drug conjugate in a xenograft model of pancreatic cancer" Europ.J.Surg.Oncol.21. 61-65 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Takahashi, M.Shimotsuma, A.Hagiwara, K.Sawai, T.Yamaguchi: "Role of peritoneal lymphatics for peritoneal metastasis and chemotherapy with mitomycin C bound to activated carbon particles" Acta Chirrugia Austriaca. 2. 76-78 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Takahashi: "Mechanism and management of cancer metastases" Journal of Japan Surgical Society. 96(8). 539-546 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Yamaguchi, T.Takahashi, K.Kitamura, E.Otsuji: "New Immunotherapy for cancer-Application of chimeric antibody" Biotherapy. 9(1). 47-50 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Yamaguchi, T.Takahashi, K.Kitamura, E.Otsuji, M.Kato, Y.Yata: "Immunotherapy using chimeric antibody" Geka Chiryo. 72(4). 439-442 (1995)

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      「研究成果報告書概要(欧文)」より
  • [Publications] D.Ichikawa, N.Hashimoto, M.Hoshima, T.Yamaguchi, K.Sawai, Y.Nakamura, T.Takahashi, T.Abe, J.Inazawa: "Analysis of numerical aberration in specific chromosomes by fluorescent in situ hybridization as a diagnostic tool in breast cancer" Cancer. 77(10). 2064-2069 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] D.Ichikawa, T.Takahashi, N.Hashimoto, M.Hoahima, K.Kitamura, T.Yamane, T.Yamaguchi, T.Abe, J.Inazawa: "Multiple primary cancers with microsatellite instability Report of a case" Jpn. J.Cancer Res.87. 105-108 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] D.Ichikawa, T.Yamagichi, M.Shirasu, K.Kitamura J.Inazawa, T.Abe, T.Takahashi: "53 gene mutation is not directly related to tumoricidal effects of preoperative radiochemohyperthermia therapy fo rectal cancers" J.Surg.Oncol.63. 87-90 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] D.Ichikawa, T.Yamaguchi, Y.Yoshioka, K.Sawai, T.Takahashi: "Prognostic evaluation of preoperative combined treatment for advanced cancer in the lowerrRectum with radiation, intraluminal hyperthermia, and 5-fluorouracil suppository" Am.J.Surg. 171. 346-350 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E.Otsuji, T.Yamaguchi, H.Tsuruta, Y.Yata, H.Nishi, K.Okamoto, K.Taniguchi, M.Kato, T.Kotani, K.Kitamura, T.Takahashi: "Applicability of monoclonal antibody fab fragments as a carrier of neocarzinostatin in targeting chemotherapy" J.Surg.Oncol.61. 149-154 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E.Otsuji, T.Yamaguchi, H.Tsuruta, Y.Yata, H.Nishi, K.Okamoto, K.Taniguchi, M.Kato, T.Kotani, K.Kitamura, T.Takahashi: "Effects of neocarzinostain-chimeric Fab conjugates on the growth of human pancreatic carcinoma xenografts" Brit.J.Cancer. 73. 1178-1182 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E.Otuji, T.Yamaguchi, H.Matsumura, K.Yamamoto, H.Tsuruta, Y.Yata, H.Nishi, K.Okamoto, K.Kitamura, T.Takahashi: "Distribution of neocarzinostatin conjugated to biotinylated chimeric monoclonal antibody Fab fragments after adminstration of avidin" Brit.J.Cancer. 74. 597-602 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Okamoto, T.Yamaguchi, N.Yamaoka, K.Kitamura, E.Otsuji, T.Kotani, M.Kato, K.Taniguchi, Y.Yata, H.Nishi, T.Takahashi: "Experimental targeting therapy of peritoneal diisemination model using huma gastric cancer cell." Biotherapy. 10. 660-661 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Yamaguchi, T.Takahashi, K.Kitamura, E.Otsuji: "Chemoimmunoconjugates" Biotherapy. 10(2). 114-120 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Yamaguchi, T.Takahashi, K.Kitamura, E.Otsuji: "New targetign therapy of cancer cells" Drug Delivery System. 47. 115-160 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Yamaguchi, T.Takahashi, K.Kitamura, E.Otsuji: "Immuno-missile therapy using tumor markers" Nihon Rinsho. 54. 208-213 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Yamaguchi, T.Takahashi, K.Kitamura, E.Otsuji, N.Yamaoka: "BRM and missile therapy" Biotherapy. 10. 605-609 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Yamaguchi, T.Takahashi, K.Kitamura, E.Otsuji, T.Kotani, M.Kato, Y.Yata, K.Okamoto, H.Nishi, D.Ichikawa, K.Yamamoto: "Diagnosis and targeting therapy of colon cancer with antibody" Gan-to-Kagakuryohou. 23. 549-553 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Yamaguchi, K.Kitamura, E.Otsuji, T.Takahashi: "Antibody therapy for digestive cancer" Biotherapy. 10. 1408-1411 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Yamamoto, T.Yamaguchi, H.Matsumura, K.Okamoato, Y.Yata, M.Kato, E.Otsuji, K.Kitamura, H.Taniguchi, K.Sawai, T.Takahashi: "Clinical application of humanized mouse chimeric antibody bound with anti-cancer agents" Biotherapy. 10. 365-367 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] C.Sakakura, E.A.Sweeney, T.Shirahama, Y.Igarashi, S.Hakomori, H.Tsujimoto, T.Imanishi, M.Ogaki, T.Ohyama, J.Yamazaki, A.Hagiwara, T.Yamaguchi, K.Sawai, T.Takahashi: "Overexpression of bax sensitizes breast cancer MCF-7 cells to cisplatin and etoposide" Surgery Today. 27. 676-679 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] C.Sakakura, E.A.Sweeney, T.Shirahama, Y.Igarashi, S.Hakomori, H.Tsujimoto, T.Imanishi, M.Ohgaki, J.Yamazaki, A.Hagiwara, K.Sawai, T.Yamaguchi, T.Takahashi: "Overexpression of bax enhances the radiation sensitivity in human breast cancer cells" Surgery Today. 27. 90-93 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] C.Sakakura, K.Koida, M.Shirasu, D.Ichikawa, M.Wakasa, M.Ogaki, J.Yamazaki, J.Inazawa, T.Abe, H.Taniguchi, A.Hagiwara, T.Yamaguchi, T.Takahashi: "Increased apoptosis rate by hyperthermochemoradiotheraphy for advanced rectal cancers" Surgery Today. 27. 773-776 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E.Otsuji, T.Yamaguchi, K.Yamamoto, H.Matsumura, H.Tsuruta, Y.Yata, H.Nishi, K.Okamoto, K.Kitamura, T.Takahashi: "Decreased renal accumulation of biotinylated chimeric monoclonal antibody-neocarzinostatin conjugate after administration of avidin" Jpn.J.Cancer Res.88. 205-212 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Nishi, T.Yamaguchi, E.Otsuji, T.Kotani, K.Taniguchi, K.Okamoto, Y.Yata, H.Tsuruta, T.Takahashi: "Reduced blood accumulation of biotinylated monoclonal antiboby a7 after the subsequent administration of avidin" Cancer Letters. 120. 127-134 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Takahashi: "Reyolution in surgery by original works" J.Japan Surgical Society. 98(9). 789-793 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Yamaguchi, K.Kitamura, E.Otsuji, K.Okamoto, H.Tsuruta, T.Takahashi: "Cancer therapy by antibody" Surgery Frontier. 4(2). 82-86 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Yamaguchi, K.Kitamura, E.Otsuji, K.Okamoto, T.Takahashi, Y.Ushijima, T.Maeda: "Diagnosis of colon cancer using monoclonal antibody" Sogo Rinsho. 46(2). 282-286 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Yamaguchi, K.Kitamura, E.Otsuji, C.Sakakura, D.Ichikawa, K.Hoshima, K.Koide, M.Shirasu, K.Okamoto, H.Aragane, A.Hagiwara, H.Taniguchi, K.Sawai, T.Takahashi: "Genetic diagnosis of stomach cancer" Geka. 59. 937-941 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E.Otsuji, T.Yamaguchi, H.Matsumura、T.Nishida、K.Yamamoto、H.Tsuruta、K.Okamaoto、Y.Yata, K.Kitamura, T.Takahashi.: "Missile therapy of pancreatic cancer using biotinilated chemoimmunoconjugate and avidin without adverse effects" Biotherapy. 11. 95-99 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E.Otsuji, T.Yamaguchi, H.Matsumura、T.Nishida、K.Yamamoto、H.Tsuruta、K.Okamoto、Y.Yata, K.Kitamura, T.Takahashi: "Efficacy of Fab fragment of chimeric antibody bound with neocarzinostatin In missile therapy of pancreatic cancer" Gann to Kagakuryohou. 24. 2285-2287 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Yamaguchi, K.Kitamura, E.Otsuji, T.Takahashi: "Cancer missile therapy with monoclonal antibody bound with anticancer drugs." Igaku-no-ayumi.184. 325-328 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Yamaguchi, T.Takahashi, K.Kitamura, E.Otsuji: Cancer missile therapy-clinical tirals, Progress In DDS 1995-96. Nakayama Shoten, 212-216 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Takahashi, M.Shimotsuma, A.Hagiwara, T.Yamaguchi: Mechanism and treatment of peritoneal carcinomatosis : intraperitoneal chemotherapy with mitomycin C bound to carbon particles、Peritoneal Carciomatosis. Kluwer Academic Publishers, 185-192 (1996)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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