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1996 Fiscal Year Final Research Report Summary

Adaptation to Nonpulsatile Mechanical Circulation : Should We Pulse in Mechanical Circulation?

Research Project

Project/Area Number 07457290
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionDepartment of Thoracic and Cardiovascular Surgery, Mie University School of Medicine

Principal Investigator

YADA Isao  Mie University School of Medicine, Department of Thoracic and Cardiovascular Surgery, Professor, 医学部, 教授 (80093152)

Co-Investigator(Kenkyū-buntansha) SHIMONO Takatsugu  Mie University Hospital, Lecture, 医学部・附属病院, 講師 (80206242)
TANI Kazuhiro  Mie University Hospital, Assistant, 医学部・附属病院, 助手 (80263010)
SHIMPO Hideto  Mie University Hospital, Lecture, 医学部・附属病院, 講師 (70179076)
Project Period (FY) 1995 – 1996
KeywordsNonpulsatile systemic circulaton / Total left heart bypass / Arterial baroreceptor / Aortic depressor nerve / Centrifugal pump / Rabbit
Research Abstract

Responses of arterial baroreceptor afferent (ABA) activity to nonpulsatile systemic circulation was directly measured.
Electrodes were placed on the left aortic depressor nerve (ADN) to measure the ABA activity in twenty-seven anesthetized rabbits. Total left heart bypass (TLHB) was conducted to obtain the nonpulsatile systemic flow. (Exp.1) To evaluate the influence of circuit priming fluid, before the starting partial left heart bypass (PLHB), before the starting TLHB after the starting PLHB and 5 min after the starting TLHB,spike counts of ADN activity were measured in the 7 animals maintaining mean aortic pressure (MAP) changes. There were no significant difference between before and after the starting PLHB.(Exp.2) To evaluate the adaptation of ABA activity to nonpulsatile flow, the spike counts of ADN activity were collected before and 5,20,30,40,50 and 60 min after the starting TLHB in the other 10 animals maintaining MAP changes. The ADN activity at 5 min after significantly increased from control (before TLHB). The activity at 30 min after significantly decreased and that level was persisted at 60 minutes after. (Exp.3) To evaluate the response of ABA activity to aortic pressure (AoP) changes, the spike counts of ADN activity were measured before, 5 and 30 min after the starting TLHB in the other 10 animals when MAP was risen and fallen by 20 mmHg. There were no significant difference when MAP was fallen. But there were significant difference when MAP was risen, percent changes in ADN activities at 5 and 30 min after the initiation of TLHB significantly less than before TLHB.
It appears that ABA activity is activated immediately after starting nonpulsatile flow, but acute adaptation of ABA activity occurs 30 min after. Also the changes of ABA activity against increase of AoP are depressed under the nonpulsatile systemic flow condition.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Isao Yada, et al: "Clinical Experience using the Biopump for Extracorporeal Circulation during Open Heat Surgery" Artificaial Organs. 17(7). 619-624 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K. Onoda et al: "Clinical experience of Nikkiso centrifugal pumps for extracorporeal circulation" Artificial Organs. 18(9). 706-710 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 矢田 公: "人工循環に拍動流は必要か" 人工臓器. 23(5). 1055-106 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T. Shimono et al: "Total Erythrocyte Destruction Time : The new index for the hemolytic performance of rotary blood pumps" Artificial Organs. 19. 571-575 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y. Shomura et al: "Clinical Experience with the Nikkiso Centrifugal Pump" Artificial Organs. 20. 568-571 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T. Shimono et al: "New Method of Evaluating Sublethal Damage to Erythrocytes by Blood Pumps" Artificial Organs. 20(6). 568-571 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Isao Yada, et al.: "Clinical Experience using the Biopump for Extracorporeal Circulation during Open Heart Surgery." Artificial Organs. 17. 619-624 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Koji Onoda, et al.: "Clinical experience of Nikkiso centrifugal pumps for extracoporeal circulation." Artificial Organs. 18. 706-710 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Isao Yada, et al.: "Should We Pulse in Mechanical Circulation?" Jpn.J.Artif.Organs. 23. 1055-1061 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takatsugu Shimono, et al.: "Total Erythrocyte Destruction Time : The new index for the hemolytic performance of rotary blood pumps." Artificial Organs. 19. 571-575 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yu Shomura, et al.: "Clinical Experience with the Nikkiso Centrifugal Pump." Artificial Organs. 20. 711-714 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takatsugu Shimono, et al.: "New Method of Evaluating Sublethal Damage to Erythrocytes by Blood Pumps." Artificial Organs. 20. 568-571 (1996)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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