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1997 Fiscal Year Final Research Report Summary

The comparison between HLA-DRB1 genotypes and the clinical features of rehumatoid arthritis and the other rheumatic diseases.

Research Project

Project/Area Number 07457606
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionKansai Medical University

Principal Investigator

OGAWA Ryokei  Kansai Medical University, Orthopedic Surgery, Professor, 医学部, 教授 (90077610)

Co-Investigator(Kenkyū-buntansha) AKAGI Shigeo  Kansai Medical University, Orthopedic Surgery, Assistant Professor, 医学部, 講師 (80148501)
TODA Yoshitaka  Kansai Medical University, Orthopedic Surgery, Associate, 医学部, 助手 (20247927)
Project Period (FY) 1995 – 1997
KeywordsRheumatoid arthritis / Osteoarthritis / Genetic marker / HLA / Cytokine / Type II collagen / Obesity
Research Abstract

The relationship between HLA-DRB1 genotypes and the clinical features of rheumatoid arthritis (RA) and other rheumatic diseases was assessed.
1.In the relationship between HLA-DRB1 genotypes and progression of bone destruction with RA (n=329), the bone destruction of the patients with homozygosity for rheumatoid susceptible alleles (HLA-DRB1**0405 and 0101) of HLA-DRB1 was more rapid significantly than that of the patients with heterozygosity or none for the susceptible alleles.
2.The difference of the gene frequencies of HLA-DRB1 between osteoarthritis (OA,n=52) and RA (n=329) patients was assessed. The frequency of HLA-DRB1**0405 was significantly higher in our patients with RA than in OA subjects. The frequency of HLA-DRB1**0101 in OA and RA patients was significantly higher than in the healthy Japanese subjects (n=493).
3.The relationship between serum levels of interleukin-6 (IL-6) and the presence of the susceptible allele HLA-DRB1 of RA (n=56). In the early phase group, the serum l … More evel of IL-6 was significantly correlated with the presence of HLA-DRB1**0405. In latephase of groups, however, there was no correlations between the serum level of IL-6 and the presence of HLA-DRB1**0405. HLA-DRB1**0405 may play an important role in controlling the expression of IL-6 in the early phase of RA,and thus be related to disease severity in Japanese RA patients.
4.The correlation between the efficacy of type II collagen (CII) treament of the RA (n=38) and the presence of HLA-DRB1**0405 allele was investigated in two groups of patients : the first group had HLA-DRB1**0405 allele (0405 group) and the second had no such allele (the non-0405 group). The differences in the number of swollen and tender joints were statistically significant between the 0405/CII and 0405/placebo groups, and between the 0405/CII and non-0405/CII groups.
5.We assessed the symptoms of knee OA induced by obesity and the effect of weight loss on the obese patients with knee OA.In the obese group, 18 patients were received a program of weight loss with a low calorie diet for 6 weeks (the diet group) and 10 patients were not done (the non-diet group). The effect of a diet therapy in this study on weight loss was a 4.6(]SY.+-。[)1.0 kg. In the diet group at final assessment, the symptoms of pain during noctural bedrest, increased pain with remaining standing for 30 min and the ability of going up stairs were significantly improved compared with baseline, although the symptoms did not significantly recovered in the non-diet group. The symptoms of knee OA is correlated with not only genetic factors but also acquired factors. Less

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Yoshitaka Toda, Seisuke Takemura, Ryokei Ogawa et al.: "Relationship between duration of rheumatoid arthritis prior to knee joint surgery and HLA-DRB1 alleles:A retrospective study" The Journal of Rheumatology. Vol.24. 2304-2307 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 竹村 清介、戸田 佳孝、小川 亮惠 他: "慢性関節リウマチ患者と変形性膝関節症患者におけるHLA-DRB1対立遺伝子頻度の比較" 臨床リウマチ. 9巻. 131-135 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 戸田 佳孝、竹村 清介、森本 忠信、小川 亮惠: "慢性関節リウマチ患者のHLA-DRB1遺伝子型と鶏軟骨ス-プを用いたII型コラーゲンによる経口トレランスの関連性について" 日本臨床免疫学会誌. 20巻. 44-51 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 戸田 佳孝、森本 忠信、小川 亮惠 他: "肥満と変形性膝関節症の諸症状との関連性について" 整形外科. 49巻. 印刷中 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 竹村 清介、戸田 佳孝、小川 亮惠 他: "慢性関節リウマチ患者における血中IL-6と既知の炎症マーカーとの関連性について" 中部整災誌. 40巻. 183-184 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshitaka Toda, Seisuke Takemura, Ryokei Ogawa et al.: "The relationship between HLA-DRB1 genotype and progression of bone destruction with rheumatoid arthritis." Japanese Journal of Rheumatology. Vol.6. 363-371 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshitaka Toda, Seisuke Takemura, Ryokei Ogawa et al.: "Relationship between duration of rheumatoid arthritis prior to knee joint surgery and HLA-DRB1 alleles : A retrospective study." J Rheumatol. Vol.24. 2304-2307 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Seisuke Takemura, Yoshitaka Toda, Takanobu Morimoto, Ryokei Ogawa et al.: "Comparison of the gene frequency of HLA-DRB1 alleles between OA and RA patients. (In Japanese)" Jpn Clin Rheumatol. Vol.9. 131-135 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshitaka Toda, Seisuke Takemura, Tadanobu Morimoto, Ryokei Ogawa: "Relationship between HLA-DRB1 genotypes and efficacy of oral type II collagen treatment using chicken cartilage soup in rheumatoid arthritis. (In Japanese)" J Clin Immun. Vol.20. 52-59 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Seisuke Takemura, Yoshitaka Toda, Tuyoshi Inoue, Tadanobu Morimoto, Ryokei Ogawa: "Relationship between well-known inflammatory markers and serum IL-6 in rheumatoid patients. (In Japanese)" Cent Jpn J Orthop Traumat. Vol.40. 183-184 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshitaka Toda, Seisuke Takemura, Tadanobu Morimoto, Ryokei Ogawa: "The relationship between obesity and symptoms in patients with osteoarthritis of the knee. (In Japanese)" Orthopedic Surgery. Vol.49 (In Press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshitaka Toda, Seisuke Takemura, Ryokei Ogawa et al.: "The relationship between HLA-DRB1 genotype and progression of bone destruction with rheumatoid arthritis." Jpn J Rheumatol. Vol.6. 363-371 (1996)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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