1997 Fiscal Year Final Research Report Summary
Risk factors for HCV vertical transmission -with special reference to maternal HCV/HIV double carrier-state-
| Project/Area Number |
07457607
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Dokkyo University School of Medicine |
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Principal Investigator |
INABA Noriyuki Dokkyo University School of Medicine, Chairman (Professor), 医学部, 教授 (70114238)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIKAWA Masayoshi Dokkyo University School of Medicine, Instructor, 医学部, 助手 (30275755)
TANAKA Soichirou Dokkyo University School of Medicine, Instructor, 医学部, 助手 (40296158)
ISHIKAWA Kazuaki Dokkyo University School of Medicine, Instructor, 医学部, 助手 (70212834)
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| Project Period (FY) |
1995 – 1997
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| Keywords | HCV / vertical transmission / high risk factors / long periods outcome / HIV / HGV |
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| Research Abstract |
The results obtained in 1997 are as follows :
1) Risk factors for HCV vertical transmission (VT) ;
The most prominent risk factors for HCV VT should be maternal double carrier-state for HCV and HIV,or maternal intravenous drug addiction. In addition, this study demonstrated one more risk valuable risk factor, maternal ALT levels at delivery (110 IU/ml).
2) Outcome of the carrier infants
Almost half of the carrier infants (persistent HCV-RNA-positive more than 6 months) became HCV-RNA (-) in their blood circulation for long periods (48 Ms, at longest).
3) Relation to Hepatitis G virus (HGV)
The infants born to HCV/HGV-positive carrier women developed HGV carrier-state highly (50%) , which means maternal double carrier-state for HCV/HGV is one of risk factors for HGV materno-infantile infection.
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[Publications] Inaba N,Okajima Y,Xiong KS,Ishikawa K,Tanaka S,Tanaka M,Watanabe H,Ota Y,Fukasawa I,Takamizawa H,Kumasaka T: "Slow virus infection in perinatology with special reference to hepatitis G virus" Recent Progress on Obs and Gyn, Eds : Cseh I and Bagdany S,Haynal Impress of Univ Med Sci, Budapest. 136-139 (1997)
Description
「研究成果報告書概要(欧文)」より
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