1996 Fiscal Year Final Research Report Summary
Evaluation of Newly Designed Adsorbents for Selective Removal of Glycosylated LDL
| Project/Area Number |
07558119
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 試験 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
MIYAURA Norio Hokkaido Univ., Fac.of Eng., Pro., 工学部, 教授 (10002049)
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| Co-Investigator(Kenkyū-buntansha) |
KAKUCHI Toyoji Hokkaido Univ., Graduate School of Enviromental Earth Science., Pro., 大学院・地球環境科学研究科, 助教授 (80113538)
ISHIYAMA Tatsuo Hokkaido Univ., Fac.of Eng., Pro., 工学部, 助教授 (00232348)
MURABAYASHI Syun Hokkaido Univ., Fac.of Eng., Pro., 工学部, 助教授 (30200306)
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| Project Period (FY) |
1995 – 1996
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| Keywords | vascular impairment / adsorbent / stirene boronic acid / plasma apheresis / diabetic oatients / human plasma / dual ligands / glc-LDL |
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| Research Abstract |
Secondary vascular impairments are frequently observed among diabetic patients. It is considered that the reason of the impairments is the existence of glycosylated compounds, especially glycosylated LDL (glc-LDL). Newly designed adsorbents were synthesized and prepared aiming for a selective removal of glc-LDL from human plasma. The polymers had two functional groups for the adsorption of glc-LDL,one is boronic acid for a glycosylated sites of glc-LDL,the other is acrylic acid (AA) for a positive charge of apoprotein. The adsorbents were evaluated in terms of glc-LDL adsorption efficiently in human plasma, and exhibited different selectivity depending on the polymer compositions. The AA compositions from 50 to 90% revealed the high selectivity for glc-LDL.The selective adsorptions of glc-LDL were not inhibited in human plasma. These results suggested that the adsorbents would be promising materials for glc-LDL apheresis.
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