1997 Fiscal Year Final Research Report Summary
Development of model mouse for nephrites syndrome (ICGN strain) and analysis on the mechanism of the onset of disease.
| Project/Area Number |
07558243
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Laboratory animal science
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| Research Institution | NATIONAL INSTITUTE OF INFECTIOUS DISEASES. |
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Principal Investigator |
ASANO Toshihiko National Institute of Infectious Diseases Division of Experimental Animal Research Chief of the Division, 動物管理室, 室長 (60100062)
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| Co-Investigator(Kenkyū-buntansha) |
OGURURA Atsuo National Institute of Infectious Diseases, Department of Veterinary Science, Sen, 獣医科学部, 主任研究官 (20194524)
TOCHIMARU Hiroyuki Hokkaido University, Department of Pediatrics, Assistant, 医学部, 助手 (80237099)
KUROSAWA Tsutomu Ohsaka University, Experimental Animal Center, Assistant Professor, 医学部・付属実験動物施設, 助教授 (60129997)
TATSUMI Haruyuki Sapporo Medical College, Department of Anatomy, Professor, 教授 (90171719)
KASAI Noriyuki Tohoku University, Experimental Animal Center, Professor, 医学部・付属実験動物施設, 教授 (60001947)
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| Project Period (FY) |
1995 – 1997
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| Keywords | model mouse / ICGN / nephrose / glomerular basement membrane / lamine / lectine / ovary transplantation / chronic renal disease |
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| Research Abstract |
The first sign of the disease was seen at age of 6 to 10 days according to electron microscopically, histochemical and immunohistological observations. Several specific characters were observed. 1) Immature type of lamine was observed at adult ICGN mouse. 2) Charge barrier of glomerular basement membrane showed abnormal character. 3) Lectine especially BSL-1 and s-WAG showed specific patterns when histochemical method was applied.
To improve their reptoductive ability, ovary transplantation method was applied. Ovaries from ICGN mice were transplanted in bursa of normal mice. When recipient mice were mated with ICGNmales, pregnancy were induced and delivered several ICGN pups.
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