1996 Fiscal Year Final Research Report Summary
Peripheral airway cell markers in lung carcinoma
| Project/Area Number |
07670674
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
SHIJUBO Noriharu Sapporo Medical University School of Medicine, Third Department of lnternal Medicine, Assistant Professor, 医学部, 講師 (70231355)
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| Co-Investigator(Kenkyū-buntansha) |
HONDA Yasuhito Sapporo Medical University School of Medicine, Third Department of lnternal Medi, 医学部, 講師 (70190270)
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| Project Period (FY) |
1995 – 1996
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| Keywords | surfactant associated proteins / surfactant protein A / surfactant protein D / Clara cell 10-kDa protein / lung cancer / lung adenocarcinoma |
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| Research Abstract |
We immunohistochemically examined surfactant protein A (SP-A) and D (SP-D) and Clara cell 10 kDa protein (CC10) in lung cancer tissue specimens. SP-A and CC10 were found only in cases of lung adenocarcinoma ; The positivities of SP-A and CC10 in cases of lung adenocarcinoma were 56% and 32%, respectively. SP-D was found in cases of lung adenocarcinoma and lung squamous cell carcinoma ; the positivities of adenocarcinoma and squamous cell carcinoma were 54% and 30%, respectively. SP-A,SP-D and CC10 were determined by means of ELISA using specific antibodies. High values of SP-A and SP-D were found in 47% and 45%, respectively, of malignant pleural effusions due to lung adenocarcinoma, whereas high values of CC10 was found in none of them. High values of SP-D was found in 33% of malignant effusions due to squamous cell carcinoma. Using a monoclonal antibody TY-5 against CC10/hUP-1, we examined CC10 expression in 44 cases with stage l lung adenocarcinoma. CC10 expression was found in 16 of the 44 cases with stage l lung adenocarcinoma. CC10-negative lung tumors had significantly greater stromal induction than that in CC10-positive lung tumors. The postoperative recurrence in patients with CC10-negative lung tumor (12 of the 28 patients) was 3.4-fold of that in patients with CC10-positive lung tumor (two of the 16 patients). CC10 presenting in lung adenocarcinoma cells may be associated with the induction of tumor dormancy.
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