• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1997 Fiscal Year Final Research Report Summary

Quantitative Analysis of Myocardial Ischemia and Viability during Dobutamine Stress Test Using Kinetic-mode and Omni-directional M-mode

Research Project

Project/Area Number 07670787
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKagawa Medical University

Principal Investigator

MIZUSHIGE Katsufumi  Kagawa Medical University Hospital, Second Department of Internal Medicine, Lecturer, 医学部・附属病院, 講師 (90166009)

Co-Investigator(Kenkyū-buntansha) NOZAKI Shiro  Kagawa Medical University Hospital, Clinical Laboratory, Assistant Professor, 医学部・附属病院, 助手 (80243773)
MASUGATA Hisashi  Kagawa Medical University Hospital, Second Department of Internal Medicine, Assi, 医学部・附属病院, 助手 (70263910)
SENDA Shoichi  Kagawa Medical University Hospital, Primary Care Medicine, Professor, 医学部・附属病院, 教授 (30145049)
MATSUO Hirohide  Kagawa Medical University, Second Department of Internal Medicine, Professor, 医学部, 教授 (90028514)
Project Period (FY) 1995 – 1997
Keywordsdobutamine stress test / quantitative analysis / omni-directional M-mode / Kinetic-mode / echocardiography / myocardial ischemia / myocardial viability / coronary artery disease
Research Abstract

1.Kinetic-mode and Omni M-mode Echocardiography : We analyzed the wall motion using wall motion image (K-mode) and omni M-mode on 2-D echocardiogram. In 28 patients with coronary stenotic lesion and 5 normals, K-mode and M-mode directing to ischemic area were recorded at baseline and during regular increment of dobutamine (D) . The excursion of wall motion (mm) was measured at 74 sites on M-mode, and divided into three groups : N (47) = perfused by normal coronary, Mild (16) = by coronary with <90% stenosis, Severe (11) = by coronary with >95% stenosis. The wall motion was gradually increasing in normal, and reduded in Severe. In Mild, the changes in wall motion was variable. The wall motion changes were absolutely different among each group during D stress, and we could quantitatively distinguish the Mild from Severe. Thus, the small alteration in wall motion reflected from coronary severity could be detected using K- and arbitrary M-mode in real-time.
2.Real-time Wall Thickness Curve … More System on 2-D Echo : We developed a new system automatically to draw a time thickness curve of LV wall. In this system, the automated border detection was simultaneously performed on both blood-endocardium and epi-pericardium borders. The thickness curve was drawn by arbitrarily setting the line perpendicular to the wall at the region of interest. In 19 volunteers and 5 with dilated cardiomyopathy (DCM) , the % systolic wall thickening (%Th) of basal (B) , mid (M) and apical (A) portions of IVS and posterior wall (PW) on LV long axis view were measured. In normals, %Th (%) of IVS was B : 28(]SY.+-。[)14, M : 32(]SY.+-。[)10 and that of PW was B : 34(]SY.+-。[)12, M : 33(]SY.+-。[)9, A : 31(]SY.+-。[)9. In DCM,%Th of IVS was B : 17(]SY.+-。[)8, M : 10(]SY.+-。[)3 and that of PW was B : 18(]SY.+-。[)6, M : 17(]SY.+-。[)8, A : 14(]SY.+-。[)4. Conclusion : We could assess the regional wall function as the % systolic wall thickening using the wall thickness measuring system, which may provide a great clinical benefit in evaluating regional wall function. Less

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] 岩藤 泰慶: "任意Mモードによるドブタミン負荷エコーと負荷BMIPP SPECTによる虚血時左室壁機能の評価" Japanese Circulation Journal. (in press).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 古本 渉: "断層心エコー像からの実時間左室壁厚自動計測によるドブタミン負荷時左室壁運動評価" Japanese Circulation Journal. (in press).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Katsufumi Mizushige: "Quantitative evaluation of left ventricular wall motion during dobutamine stress using kinetic-mode and omni-directional M-mode echocardiography" Circulation. 96・8(Supplement). I-96 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Katsufumi Mizushige: "Quantitative measurement of left ventricular systolic wall thickening by two-dimensional motion imaging echocardiography(K-mode)" Circulation. 94・8(Supplement). I-378 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tetsuya Tanaka: "Evaluation of left ventricular wall function by measurement of systolic thickening using kinetic(K)-mode echocardiography" Japanese Circulation Journal. 60・7. 478 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Katsufumi Mizushige: "Quantitative analysis of left ventricular wall motion abnormality using real-time 2-dimensional echocardiographic motion imaging system" J Am Coll Cardiol. (Supplement). 57A (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松尾 裕英: "内科学" 朝倉書店, 13 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 水重 克文: "心臓病診療プラクティス 冠動脈疾患を心エコー図で診る" 文光堂, 2 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K Mizushige: "Effects of short-tem administration of sublingual nifedipine on coronary arterial wall elastic properties : evaluation by intravascular ultrasound" J Cardiovasc Pharmacol. 29-4. 508-514 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K Mizushige: "Quantitative evaluation of left ventricular wall motion during dobutamine stress using kinetic-mode and omni-directional M-mode echocardiography" Circulation. 96-8. I-96 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H Morita: "A new noninvasive method of diagnosing vasospastic angina based on dilation response of the left main coronary artery to nitroglycerin as measured by echocardiography" J Am Call Cardiol. 27-6. 1450-1457 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K Mizushige: "Quantitative measurement of left ventricular systolic wall thickening by two-dimensional motion imaging echocardiography (K-mode)" Circulation. 94-8. I-378 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T Tanaka: "Evaluation of left ventricular wall function by measurement of systolic thickening using kinetic (K) -mode echocardiography" Jpn Circ J. 60-7. 478 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K Mizushige: "Quantitative analysis of left ventricular wall motion abnormality using real-time 2-dimensional echocardiographic motion imaging system" J Am Coll Cardiol. 57A (1995)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1999-03-16  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi