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1996 Fiscal Year Final Research Report Summary

Enhacement of the effects of an angiogenesis inhibitor on murine tumors by hyperthermia

Research Project

Project/Area Number 07671033
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKansai Medical University

Principal Investigator

TANAKA Yoshimasa  KANSAI MEDICAL UNIVERSITY,FUCULTY OF MEDICINE PROFESSOR, 医学部, 教授 (40131445)

Co-Investigator(Kenkyū-buntansha) HARIMA Youko  KANSAI MEDICAL UNIVERSITY,FUCULTY OF MEDICINE ASSISTANT PROFESSOR, 医学部, 講師 (80140276)
AKAGI Kiyoshi  KANSAI MEDICAL UNIVERSITY,FUCULTY OF MEDICINE ASSISTANT PROFESSOR, 医学部, 講師 (30098115)
Project Period (FY) 1995 – 1996
KeywordsExperimenta tumor / Inhibitor of angiogrnesis / Heat treatment
Research Abstract

We investigated the effect of angiogenesis inhibitors (FR-118487 and TNP-470) on two murine tumors (FM3A, SCC-7) with and without hyperthermia. When angiogenesis inhibitors were adminstered immediately after tumor implantations there was no tumor growth. As the tumor diameter increased, the antitumor effect of inhibitors decreased. When FR-I 18487 was combined with hyperthermia, the antitumor effect was potentiated. This study suggested that angiogenesis inhibitors show their maximal effect against small tumors and have increased activity when combined with hyperthermia.

  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Shigeki Ikeda: "Enhancement of effect of an angiogenesis inhibitor on murine fumor by hyperthermia" Oncology Reports. 5. 181-184 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takashi Murata: "Studies on the effectiveness of hyperthermia combined with arterial therapeutic blackage in the Treatment of fumors." Oncology Reports. 5. 709-712 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Reiko Nasu: "Blood flow influences vascular growth during tumour angiogenesis" British Journal of Cancer. 79. 780-786 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takashi Murata: "Relevance of a new impedance matching,or subtrap,method for the reduction of pain during hyperthermia" Acta Oncologica. 37. 485-488 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shigeki Ikeda, Kiyoshi Akagi, Yoshimasa Tanaka: "Enhancement of effect of an angiogenesis inhibitor on murine tumor by hyperhtermia" Oncology Report. 5. 181-184 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takashi Murata, Kiyoshi Akagi, Masahiro Imamura, Reiko Nasu, Hiroyuki Kimura, Kenji Nagata, Yoshimasa Tanaka: "Studies on the effectiveness of hyperthermia combined with arterial arterial therapeutic blockage in the treatment of tumors Part 3. Clinical studies on the effectiveness of hyperthemia combined with arterial embolization using degradable starch microsphere" Oncology Reports. 5. 709-712 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Reiko Nasu, Hiroyuki Kimura, Kiyoshi Akagi, Takashi Murata, Yoshimasa Tanaka.: "Blood flow influences vascular growth during tumor angiogenesis." British Journal of Cancer. 79. 780-786 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takashi Murata, Valentina V.Ostapenko, Kiyoshi Akagi, Masahiro Imamura, Reiko Nasu, Hiroyuki Kimura, Yoshimasa Tanaka: "Relevance of a new impedance matching, or subtrap method, for the reduction of paiin during hyperthermia" ACTA Oncologica. 37. 485-488 (1998)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-12-08  

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