1997 Fiscal Year Final Research Report Summary
Brain metabolism in bipolar patients measured by Magnetic resonance spectroscopy
| Project/Area Number |
07671065
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
YAMADA Naoto Shiga Univ Med Sci, Psychiatry, Associate Professor, 医学部, 助教授 (50166724)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Tadafumi Shiga Univ Med Sci, Psychiatry, Assistant, 医学部, 助手 (30214381)
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| Project Period (FY) |
1995 – 1997
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| Keywords | MRS / Brain imaging / Bipolar disorder / phosphocreatine / sleep deprivation / Brain metabolism |
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| Research Abstract |
We developed the phosphorus-31 one-demensional chemical shift imaging (^<31>P-1DCSI) method and applied this method to the investigations of brain energy metabolism in patients with bipolar disorder. The phosphocreatine peak area was decreased in the left frontal lobe of bipolar patients and it was signficantly negatively correlated with scores of Hamilton Depression Rating Scale. This finding was not observed in other psychiatric disorders, such as major depression, schizophrenia, and panic disorder. We used proton magnetic resonance spectroscopy (^1H-MRS) to examine the left frontal lobe in bipolar patients and found that total creatine was decreased in this region, which confirmed the previous finding of phosphocreatine. We further examined the photic stimulation induced alteration of brain phosphorus metablism to examine subtle metabolic change in these patients. Bipolar patients had different reaction patterns to photic stimulation, which suggest trait-dependent abnormality of brain energy metabolism. To examine the mechanisms of action of sleep deprivation on bipolar depression, we investigated the effects of sleep deprivation on brain phosphorus metabolism in normal volunteers. There found a large inter-individual variation in metabolic response to sleep deprivation.
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[Publications] Kato, T., Shioiri, T., Murashita, J., Hamakawa, H., Takahashi, Y., Inubushi, T.and Takahashi, S.: "Lateralized Abnormality of High Energy Phosphate Metabolism in the Frontal Lobes of Patients with Bipolar Disorder Detected by Phase-Encoded ^<31>P-MRS." Psychological Medicine. 25. 557-566 (1995)
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「研究成果報告書概要(欧文)」より
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[Publications] Kato, T., Shioiri, T., Murashita, J., Hamakawa, H., Takahashi, Y., Inubushi, T.and Takahashi, S.: "Lateralized abnormality of high energy phosphate and bilateral reduction of phosphomonoester measured by ^<31>P-MRS of the frontal lobes in schizophrenia" Psychiatry Research : Neuroimaging. 61. 151-160 (1995)
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[Publications] Kato T,Hamakawa, H., Shioiri, T., Murashita, J., Takahashi, Y., Takahashi, S.and Inubushi, T.: "Choline-containing compounds detected by proton magnetic resonance spectroscopy in the basal ganglia in bipolar disorder" Journal of Psychiatry & Neuroscience. 21. 248-254 (1996)
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