1996 Fiscal Year Final Research Report Summary
INTERPOSITION NERVE GRAFTS TO RESTORE POSTOPERATIVE URINARY AND SEXUAL FUNCTIONS IN RATS.
| Project/Area Number |
07671350
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | ASAHIKAWA MEDICAL COLLEGE |
|---|
Principal Investigator |
KONO Toru Asahikawa Medical College, Assistant, 医学部, 助手 (60215192)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KAKISAKA Akitoshi Asahikawa Medical College, Assistant, 医学部, 助手 (60194677)
MIYATA Masanobu Asahikawa Medical College, Assistant Professor, 医学部, 講師 (90174193)
|
|---|
| Project Period (FY) |
1995 – 1996
|
| Keywords | cancer of the rectum / autonomous nerve preservation operation / interposition nerve grafts auto-transplantation / tetanus toxin C fragment / bladder function |
|---|
| Research Abstract |
Aim
By surgery treatment of cancer of the rectum discovered early comparatively, the autonomous nerve preservation operation in the pelvis which considered function maintenance after operation is recommended, but there is the case that curability of cancer is thought about in the advanced case, and cannot but abandon preservation operation currently. This study is a fundamental study to make clear the propriety of new operation method development letting a function after advaned cancer operation maintains by using an interposition nerve grafts auto-transplantation.
Methods and Results
(1) In the graft group, tetanus toxin C fragment (transsynaptic retrograde transporter) was apllied to the bladder wall with a purpose to confirm the regeneration which was occured via the grafted nerve. After 2 or 3 weeks, parasympathetic nerve cells in lower spinal cord (S2-4) were retrogradely stained by tetanus toxin C fragment via the transplanted and reproducted nerve.
(2) After 2 or 3 weeks, the recovered bladder function wasn't recognized.
(3) After 5 or 6 weeks, the function recovery preservation was recognized and was almost near by bladder function in normality.
Summary
I was able to suggest the possibility that an interposition nerve grafts auto-transplantation was extremely useful for function recovery after operation in advanced rectal cancer patients.
|
Research Products
(22 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Publications] Kono, T., Iwamoto, J., Y,Yamamoto, Kakisaka, A., Kasai, S., and M.Mito.: "Nitric Oxide (NO) is released from liver into the abdominal cavity in the acute liver failure animal model.19GC01 : FASEB J." 10 (3). A705 (1996)
Description
「研究成果報告書概要(欧文)」より
-
[Publications] Kono, T., Iwamoto, J., Yamamoto, Y., Kakisaka, A., Kasai, S.and Mito, M.: "Intraabdominal Nitric Oxide (NO) production in rats : Measurements in expelled air." Gastroenterology. 110 (4). A1239 (1996)
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
-
-
-
