1996 Fiscal Year Final Research Report Summary

Changes of Serum and Urinary Myoglobin Following Temporaly Occlusion of the Abdominal Aorta

Research Project

Project/Area Number	07671480
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Thoracic surgery
Research Institution	Nagasaki University
Principal Investigator	TAKAGI Masatake Nagasaki University, School of Medicine, Assistant, Professor, 医学部, 助教授 (30136642)
Co-Investigator(Kenkyū-buntansha)	HASHIYADA Hiroshi Nagasaki University, School of Medicine Hospital, Assistant, 医学部・附属病院, 助手 (50284691) MIYAGAWA Naotake Nagsaki Universitiy, School of Medicine Hospital, Lecture, 医学部・附属病院, 講師 (10136666) KUGIMIYA Toshiyasu Nagasaki University, School of Medicine, Professor, 医学部, 教授 (30039820)
Project Period (FY)	1995 – 1996
Keywords	ACUTE ARTERIAL OCCLUSION / MYOGLOBINEMIA / ACUTE RENAL FAILURE / alpha-fetoprotein
Research Abstract	Thirty four patients with abdominal aortic aneurysm, who underwent graft replacement at Nagasaki University Hospital between 1995 and 1997, were enrolled in this study. Changes of blood mioglobin (Mb), lactic acid (Lc) and superoxide desmutase (SOD) were measured before and after aortic cross-clamping. Mb showed significant increase after cross-clamping. However, no correlation was found between clamping time and the blood levels of the above substances. Five of 34 patients showed abnormal myoglobinemia after crossclamping. Further study is necessary for clarifying mechnisms of these phenomenon.