Development of BrdU releasing polymer and its use on radiosensitization of brain tumors : experimental study.

1996 Fiscal Year Final Research Report Summary

• Project/Area Number: 07671549
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Kansai Medical University
• Principal Investigator: KAWAMOTO Keiji Faculty of Medicive, Kansai Medical University, Professor, 医学部, 教授 (70077741)
• Co-Investigator(Kenkyū-buntansha): KASAI Harubumi Faculty of Medicive, Kansai Medical University, Associate Professoar, 医学部, 助手 (80268341) ; IMAHORI Takumi Faculty of Medicive, Kansai Medical University, Associate Professoar, 医学部, 助手 (10257909) ; NUMA Yoshihiro Faculty of Medicive, Kansai Medical University, Associate Professoar, 医学部, 講師 (40208278) ; TSUCHIDA Takahiro Faculty of Medicive, Kansai Medical University, Associate Professoar, 医学部, 講師 (10181249)
• Project Period (FY): 1995 – 1996
• Keywords: Bromodeoxyuvidine / Sustained release polymer / 9L glioma / Radiosensitizer

Research Abstract

Ethylene vinyl acetate copolymer is a convenient vehicle capable of sustained drug release. BrdU,thymidine analogue, is incorporated into S-phase cells and enhances susceptibility of cells to irradiation and UV.However, BrdU was not used generally because of its systemic toxicity. We developed BrdU polymer capable of sustained BrdU release. We applied this polymer to subcutaveous rat 9L glioma and examind radiosensitizing effect of BrdU polymer. However, we did not find difference in tumor size between rats reated by irradiation plus polymer and those treated only by irradiation. The reason why BrdU polymer did not show radiosensitizing effect glioma in vivo is under investigation.