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1996 Fiscal Year Final Research Report Summary

Apoptosis in ischemia and reperfusion injury of limb.

Research Project

Project/Area Number 07671634
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionFUKUOKA UNIVERSITY

Principal Investigator

OHJIMI Hiroyuki  Fukuoka Univ.Hospital, Associate Professor., 助教授 (60160488)

Project Period (FY) 1995 – 1996
Keywordsapoptosis / limb / ischemia / reperfusion injury
Research Abstract

The mechanisms of cell death have been subject to debate. We studied whether an apoptotic type of cell death occurs in skin after ischemia and reperfusion injury.
METHODS AND RESULTS : We studied skin samples of rabbit lower limb that underwent ischemic condition achieved by 8 hours followed by 180 minutes of reperfusion. Extensive formation of DNA strand breaks, the typical biochemical feature of apoptosis was detected with the use of the in situ DNA end-labeling method. Apoptotic cells were observed particularly in the border zones of histologically necrotic skin, whereas very few apoptotic cells were present in the remote no necrotic skin.
CONCLUSIONS : This study provides evidence that in addition to overt necrosis, a subset of skin undergo apoptosis during ischemia-reperfusion injury. Apoptosis may provide a new target for skin slough during evolving ischemia and repurfusion injury in humans.

  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] Ohjimi, H, Ogata, K., and Ojimi, T.: "A New method for the relief of adult phimosts." J.Urol.153. 1607-1609 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohjimi, H., Ogata, K..: "An Elastic plastic splint to compress the ear after reconstriction using a temper a perotal fascial temp" Arm.Plast.Surg. 36(6). 652-654 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohjimi, H., Ogata, K., Setsu, Y: "Modification of the gluteum maximams V-Yadvancement flap for casralulas" Plast.Resnstr.Surg.98(7). 1247-1252 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohjimi, H., Ogata, K., Ohjimi, T: "A New method for the relief of adult phimosis." J.Urol. 153. 1607-1609 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohjimi, H., Ogata, K: "An Elastic plastic splint to compress the ear after teconstruction using a temporoparietal fascial flap." Ann.Plast.Surg. 36 (6). 652-654 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagasaka, S., Fukushima, T., Goto, K., Ohjimi, H., Iwabuchi, S., Maehara, F: "Treatment of scalp arteriovenous malformation." Neurosurgery. 38 (4). 671-677 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohjimi, H., Ogata, K., Setsu, Y., Haraga, I: "Modification of gluteus maximus V-Y advancement flap for sacral ulcers : The gluteal fasciocutaneous flap method." Plast.Reconstr.Surg. 98 (7). 1247-1252 (1996)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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