1996 Fiscal Year Final Research Report Summary

The Synthesis, Metabolism and Biological Roles of Nitric Oxide (NO) in the Eye

Research Project

Project/Area Number	07671940
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Ophthalmology
Research Institution	Aichi Medical University
Principal Investigator	IWAKI Masayoshi Aichi Medical University, Associate Professor, 医学部, 助教授 (10093163)
Co-Investigator(Kenkyū-buntansha)	MIZUTANI Satoshi Aichi Medical University, Associate Professor, 医学部, 助教授 (60166014)
Project Period (FY)	1995 – 1996
Keywords	nitric oxide / NO / nitric oxide synthase / endophthalmitis / uveitis / experimental uveitis / cataract / complicated cataract
Research Abstract	We obtained the following results and future projects throughout the research : 1) Using the animal model of endotoxin-induced uveitis, we found that nitric oxide (NO) functions as an inflammation-mediating factor in the eye. The constitutive form of NO synthase appeared to play a critical role at the onset of endotoxin-induced uveitis. 2) Lens epithelial cells and crystalline lens also were found to produce NO in inducible manner both in vitro and in vivo. The result suggested that NO may play some roles in cataractgenenesis in vivo. 3) From these results, we concluded that NO must play significant roles in the eye both physiologically and pathologically. Further exprimental works especially in cataract formation and quantitative analysis of NO in the eye are needed.

(4 results)