1997 Fiscal Year Final Research Report Summary

Search for the salivary proline-rich peptide P-B related genes

Research Project

Project/Area Number	07672034
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Functional basic dentistry
Research Institution	Nippon Dental University Junior College at Niigata
Principal Investigator	ISEMURA Satoko Nippon Dental University Junior College at Niigata, Professor, 教授 (10112963)
Project Period (FY)	1995 – 1997
Keywords	saliva / salivary gland / proline-rich protein / human gene / P-B / P-B1 / PBI
Research Abstract	The nucleotide sequence of gene PBI,a putativetranslational product of which is homologous to salivary prolin-rich protein P-B has been determined. PBI is 6.4kb long and contains 3 exons. The present result indicates that PBI is capable of coding for the precursor of proline-rich protein which we have designated P-B1. The P-B1 precursor is composed of 134 amino acid residues including 22 residues of signal sequence, 23 residues of N-terminal sequence, five repeating units of 13 to 14 residues and 22 residues of C-terminal sequence. The signal sequence of this precursor is identical with that of the P-b precursor. The N-terminal 61 residue sequence of P-B1 has homology of 75% as compared with the whole sequence of P-B (57 residues), when deletion of 4 residues is taken into account. P-B1 is 55 residues longer than P-B.

(2 results)