1997 Fiscal Year Final Research Report Summary
Search for the salivary proline-rich peptide P-B related genes
| Project/Area Number |
07672034
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Nippon Dental University Junior College at Niigata |
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Principal Investigator |
ISEMURA Satoko Nippon Dental University Junior College at Niigata, Professor, 教授 (10112963)
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| Project Period (FY) |
1995 – 1997
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| Keywords | saliva / salivary gland / proline-rich protein / human gene / P-B / P-B1 / PBI |
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| Research Abstract |
The nucleotide sequence of gene PBI,a putativetranslational product of which is homologous to salivary prolin-rich protein P-B has been determined. PBI is 6.4kb long and contains 3 exons. The present result indicates that PBI is capable of coding for the precursor of proline-rich protein which we have designated P-B1. The P-B1 precursor is composed of 134 amino acid residues including 22 residues of signal sequence, 23 residues of N-terminal sequence, five repeating units of 13 to 14 residues and 22 residues of C-terminal sequence. The signal sequence of this precursor is identical with that of the P-b precursor. The N-terminal 61 residue sequence of P-B1 has homology of 75% as compared with the whole sequence of P-B (57 residues), when deletion of 4 residues is taken into account. P-B1 is 55 residues longer than P-B.
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