1997 Fiscal Year Final Research Report Summary
A STUDY OF ERYTHROCYTE MEMBRANE PHOSPHOLIPIDS IN SCHIZOPHRENIC PATIENTS.
| Project/Area Number |
07807090
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kumamoto University |
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Principal Investigator |
YAMASHITA Kensyou Kumamoto University, Medical School Hospital, Assistant, 医学部・附属病院, 助手 (10230418)
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| Co-Investigator(Kenkyū-buntansha) |
TERAOKA Kazuhiro Kumamoto University, Medical School, Assistant, 医学部, 助手 (60284759)
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| Project Period (FY) |
1995 – 1997
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| Keywords | schizophrenia / erythrocyte / membraine / phospholipid / molecular species / essential fatty acids / microcirculation |
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| Research Abstract |
Erythrocyte membrane phospholipid classes and molecular species were analyzed in drug-naive schizophrenic patients and normal control subjects. The results were (1) a significantly reduced level of phosphatidylcholine (PC), an increased level of sphingomyelin (SM), and reduced PC/SM ratio in erythrocyte membrane phospholipid classes in the schizophrenic patients ; (2) significantly reduced levels of molecular species containing essential fatty acids (EFAs) and increased of the molecular species not containing EFAs in the patients ; (3) positive correlations between the PC level or PC/SM ratio and molecular species containing EFAs, and negative correlations between the PC level or PC/SM ratio and molecular species not containing EFAs in the patients. These changes may produce an increase in membrane dynamics and a disturbance of microcirculation (lower erythrocyte deformability etc). If these changes are not only at the erythrocytes but also at neurons, there would be changes of membrane functions of neurons in schizophrenia patients.
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