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2000 Fiscal Year Final Research Report Summary

Molecular Science on the Specific Roles of Metal Ions in Biological Functions.

Research Project

Project/Area Number 08249105
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Research InstitutionOkazaki National Research Institutes

Principal Investigator

KITAGAWA Teizo  Okazaki National research Institutes Professor, 分子科学研究所, 教授 (40029955)

Co-Investigator(Kenkyū-buntansha) KIMURA Eiichi  Okazaki National Research Institutes, 医学部, 教授 (30034010)
NISHINO Takeshi  Nihonn Medical College Professor, 教授 (40094312)
MORISHIMA Isao  Kyoto University Professor, 工学部, 教授 (50026093)
井口 洋夫  岡崎国立共同研究機構, 分子科学研究所, 名誉教授 (00100826)
渡辺 芳人  岡崎国立共同研究機構, 分子科学研究所, 教授 (10201245)
Project Period (FY) 1996 – 2000
KeywordsMetallo-proteins / Metallo-nuclic acid / biometals / gene control / heme proteins / cytochromes / cytochrome oxidase / oxygen activation
Research Abstract

The project members consisted of four teams focused on investigations of energy conversion, material transformation, signal transduction, and gene expression. Members were encouraged to participate in various kinds of collaborative networks of researchers having different expertise in physical chemistry, coordination chemistry, biochemistry, and molecular biology. Eleven major topics were extensively studied by the four teams including energy conversion in photosynthesis and respiration, activation mechanisms of small molecules by biometals, signal initiation, transduction and reception by metalloproteins, and regulation of gene expression by biometallic compounds. Each of the four teams consisted of the several core members, who were selected by the committee of leaders of the four teams, and the recruited members, who were selected from general applicants by a committee of the Ministry of Education, Science, Sports, and Culture. The total numbers of members were 67, 57, 58, and 50 for the 1^<st>, 2^<nd>, 3^<rd>, and 4^<th> years. The number and composition of members were changed every year. All members were requested to present new results as posters in a two-day open workshop once a year, to which a few distinguished foreign bioinorganic chemists were invited to evaluate the results and to deliver a lecture. The activity has been summarized as SBIC News in J.Biol.Inorg.Chem. 5, 410-415 (2000). The rich accomplishments of individual members are published as focused reviews and original papers in a special issue of J.Inorg.Biochem. 82, #1-4 (2000).

  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] T.Tomita et al.: "Resonance Raman investigation of Fe-N-O structure of nitrosylheme in myoglobin and its mutants."Journal of Physical Chemistry Part B. 103. 7044-7054 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Iwase et. al.: "Infrared evidence for Cu_<B-> ligation of photodissociated CO of cytochrome c oxidase at ambient temperatures and accompanied deprotonation of a carboxyl side chain of protein."Journal of American Chemical Society. 121. 1415-1416 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Iwasaki et al.: "Modulation of the remote heme site geometry of recombinant mouse neuronal nitric oxide synthase by the N-terminal hook region"Journal of Biological Chemistry. 274. 7705-7713 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] E.Kimura et al.: "Dynamic Enolate Recognition in Aqueous Solution by Zinc (II) in a Phenacyl-Pendant Cycle Complex : Implications for the Role of Zinc (II) in Class II Aldolases."Journal of American Chemical Society. 121. 1267-1274 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Goto et al.: "Mechanisms of Sulfoxidation Catalyzed by High-Valent Intermediates of Heme Enzymes : Electron Transfer vs Oxygen Transfer Mechanism."Journal of American Chemical Society. 121. 9497-9502 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Kitagawa: "Progress report on molecular biometallics (1996-2000), a project of the priority areas for research under the auspices of the Japanese Government"Journal Biological Inorganic Chemistry. 5. 410-415 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Kitagawa: "Special Issue on Japanese Molecular Biometallics"Journal Inorganic Biochemistry. 82, issues. 1-4 (2000)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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