1998 Fiscal Year Annual Research Report

高次脳機能のシステム的理解

Research Project

Project/Area Number	08279101
Research Category	Grant-in-Aid for Scientific Research on Priority Areas (A)
Research Institution	Tohoku University
Principal Investigator	丹治順東北大学, 医学部, 教授 (10001885)
Co-Investigator(Kenkyū-buntansha)	彦坂興秀順天堂大学, 医学部, 教授 (70120300) 小野武年富山医科薬科大, 医学部, 教授 (50019577) 合原一幸東京大学, 工学部, 助教授 (40167218) 木村實大阪大学, 健康体育部, 教授 (40118451) 吉澤修治東京大学, 工学部, 教授 (90010959)
Keywords	高次脳機能 / 実験的神経科学 / 計算論的神経科学 / コンピュータシミュレーション / イメージング / 認知 / 行動 / 記憶
Research Abstract	この研究プロジェクトにおいては、生物を対象とした実験研究によって脳の高次機能の発現と制御の実態を明らかにし、その動作原理とシステム的な動作様式を理論的に解明することを統合的なアプローチによって目指すことを目的とした.そのために、実験的神経科学者、計算論的神経科学者、非襲侵的脳機能イメージングによる研究者から成る研究グループを組織し、それぞれの研究者が専門領域の研究をすすめるだけではなく、ワークショップ・シンポジューム・研究会を数多く行って、多面的なアプローチによる研究をめざした。ニュースレター「高次脳機能のシステム的理解」を定期的に発行して研究者相互の研究理解促進をはかるとともに、コンピューターネットワークを形成し、独自のホームページを作成して、研究情報の迅速な連絡を行った。研究は全体的に順調に進捗し、具体的な成果が次々と得られはじめている。すでに得られた研究成果は、脳機能の多くの側面に及んでいるが、なかでも(1)運動の随意的選択機構における前頭連合野の機能解明、(2)小脳細胞の動作原理に関する理論の実験的裏付け、(3)側頭葉におけるメモリー依存的運動誘導機能の発見、(4)海馬と海馬周辺皮質を流れる情報の実時間的イメージング、前頭葉ニューロンにおける報酬予測的活動の発見などが特に顕著な研究成果として挙げられる。これらはいずれも学会発表のみならず、国際的な科学雑誌に発表されるに至った。

Research Products
(41 results)

All Other

All Publications (41 results)

[Publications] Shima K,& Tanji,J.: "Role for cingulate motor area cells in voluntary movement selection based on reward." Science.282. 1335-1338 (1998)
[Publications] Hoshi E.,Shima K.,& Tanji,J.: "Task-dependent selectivity of movement-related neuronal activity in the primate prefrontal cortex." J Neurophysiol.80. 3392-3397 (1998)
[Publications] Shima K.,& Tanji J.: "Both supplementary and presupplementary motor areas are crucial for the temporal organization of multiple movements." J Neurophysiol.80. 3247-3260 (1998)
[Publications] Kawashima R,Tanji J,Fukuda H,et.al: "Oculomotor sequence learning: a positron emission tomography study." Exp Brain Res.122. 1-8 (1998)
[Publications] Shima K,& Tanji,J.: "Involvement of NMDA and non-NMDA receptors in the neuronal responses of the primary motor cortec to input from the supplementary motor area and somatosensory cortex: studies of task-performing monkeys." Jpn J Physiol.48. 275-290 (1998)
[Publications] Fujii N.,Mushiake.,H.& Tanji,J.: "An oculomotor representation area within the ventral premotor cortex." Proc Natl Acad Sci U S A.95. 12034-12037 (1998)
[Publications] Fujii N.,Mushiake,H.& Tanji,J.: "Intracortical microstimulation of bilateral frontal eye field." J Neurophysiol.79. 2240-2244 (1998)
[Publications] 丹治順: "補足運動野と手の運動の順序制御" 神経進歩. 42. 29-38 (1998)
[Publications] 虫明元: "前補足運動野と手の運動のプランニング" 神経進歩. 42. 39-48 (1998)
[Publications] 平岡、吉澤: "多重化砂時計型ネットを用いた広いクラスの曲面によるデータフィッティング" 日本神経回路学会誌. 5. 3-9 (1998)
[Publications] 平岡、吉澤: "砂時計型ネットを用いた多価関数の学習" 電子情報通信学会論文誌. J81-D-II(11). 1653-1660 (1998)
[Publications] 寺田,田中,吉澤: "筋肉のHodgkin-Huxley方程式の2パラメータ分岐" 電子情報通信学会論文誌. J81-A(10). 1331-1338 (1998)
[Publications] Hiraoka,K.& Yoshizawa,S.: "Recalling of many-valued functions by successive iteration on" Proc.5th Internationaal Conf.on Neural Info.Proc.3. 1389-1392 (1998)
[Publications] Morinaga,S.& Yoshizawa,S.: "Control of spurious memories by usingself-coupling weight" Proc.5th Internationaal Conf.on Neural Info.Proc.3. 1389-1392 (1998)
[Publications] Watanabe K.,& Kimura M.: "Dopamine receptor-mediated mechanisms involved in the expression of learned activity of primate striate neurons." J Neurophysiol.79. 2568-2580 (1998)
[Publications] Kimura M,et.,al: "Potentiation of phosphoinositide-derived signals induced during LTP in rat intact brain." Neuro Report. 9. 2085-2088 (1998)
[Publications] Graybiel A M Kim u ra M.,et.,al: "Role of Nigrostriatal dopamine system in learning to perform sequential motor tasks in a predictive manner." in press. (1998)
[Publications] Graybiel AM and Kimura M.et.,al: "Neurons of CM and Pf in the thalamus supply striate neurons with multisensory information with alerting value." (submitted to J.Neurosci.). (1998)
[Publications] Wolpert D,Miall C,Kawato M: "Internal models in the cerebellum." Trends in Cognitive Sciences. 2. 338-347 (1998)
[Publications] Wolpert D,& Kawato M: "Multiple paired forward and inverse models for motor control." IEICE Trans.Fund.of Elec.Comn.Comp.Sci.E81-A. 1317-1329 (1998)
[Publications] Y.Sakumura & K.Aihara: "Stochastic Resonance by Modulation Detecting Neuron." Proc.of ICONIP 98. 2. 951-954 (1998)
[Publications] M.Watanabe,K.Aihara & S.Kondo: "A Dynamical Neural Net work with Temproal Coding and Functional Connectivity." Biol.Cybern. 78. 87-93 (1998)
[Publications] M.Watanabe & K.Aihara: "Chaos in Neural Networks Composed of Coincidence Detector Neurons." Neural Networks. 10. 1353-1359 (1998)
[Publications] Toyama,K & Yoshizawa,S.et.,al: "A new method for magnetoencephalography(MEG):Three dimensional magnetometer-spatial filter system." Neuroscience. 95(in press). (1998)
[Publications] Sakai,K.,Hikosaka,O.,Miyauchi,S.et.al: "Transition of brain activation from frontal to parietal areas in visuo-motor sequence learning." J.Neurosci.18. 1827-1840 (1998)
[Publications] Lu,X.,Hikosaka,O.,Miyachi,S.: "Role of monkey cerebellar nuclei in skill for sequential movement." J Neurophysiol.79. 2245-2254 (1998)
[Publications] Takino R,Hikosaka O.,Miyauchi,S.et.,al: "Separate cerebellar areas for motor control." NeuroReport. 9. 2359-2363 (1998)
[Publications] Kawagoe R,Takikawa Y.: "Expectation of reward modulates cognitive signals in the basal ganglia." Nat.Neurosci.1. 411-416 (1998)
[Publications] Shima K,& Tanji,J: "Involvement of NMDA and non-NMDA receptors in the neuronal responses of the primary motor cortex to input from the supplementary motor area and somatosensory cortex: studies of task-performing monkeys." Jpn J Physiol.48. 275-290 (1998)
[Publications] Nakamura K.,Sakai,K.,Hikosaka,O.: "Neuronal activity in medial frontal cortex during learning of sequential procedures." J.Neurophysiol.80. 2671-2687 (1998)
[Publications] Hikosaka O,Miyashita K.,: "Differential roles of the frontal cortex,basal ganglia,and cerebellum in visuomotor sequence learning." Neurobiology of Learning and Memory. 70. 137-149 (1998)
[Publications] Hikosaka,O.: "Neural systems for control of voluntary action-ahypothesis." Adv.Biophysics. 35. 81-102 (1998)
[Publications] Takikawa,Y.,Hikosaka,O.et.,al: "Presaccadicomnidirectional burst activity in the basal interstitial nucleus in the monkey cerebellum." Exp.Brain res.121. 442-450 (1998)
[Publications] 彦坂興秀: "手の順序動作の手続き的学習." 神経研究の進歩. 42. 106-116 (1998)
[Publications] Ikeda,H.,Nishijo,H.,Ono,T.et.,al: "Generators of visual evoked potentials investigated by dipole tracing in the human occipital cortec." Neurosci.84. 723-739 (1999)
[Publications] Fujii N.,Mushiake.,H.& Tanji,J.: "Active spatial information processing in the septo-hippocampal system." Hippocampus. in press. (1998)
[Publications] Yonemori,M.,Nishijo,H.,Ono,T.: "Orbital cortex neurinal responses during an odor-based conditioned associative task in rats." Neuroscience. in press. (1999)
[Publications] Kondo,T.,Ono,T.,anishijo,H.et.,al.: "Mechanisms of umami taste preference and aversion in rats." J.Nutrition. 35(in prss). (1999)
[Publications] Matsumura,N.,Nishijo,H.,Ono,T: "Spatial and task-dependent neuronal responses during real and virtual translocation in the monkey hippocampal formation." J.Neurosci. in press. (1999)
[Publications] 彦坂興秀: "手の順序動作の手続き的学習." 神経研究の進歩. 42. 106-116 (1998)
[Publications] Ikeda,H.,Nishijo,H.,Ono,T.et.al: "Generators of visual evoked potentials investigated by dipole tracing in the human occipital cortec." Neurosci.84. 723-739 (1999)

1998 Fiscal Year Annual Research Report

高次脳機能のシステム的理解

Principal Investigator

丹治 順 東北大学, 医学部, 教授 (10001885)

Research Products

[Publications] Shima K,& Tanji,J.: "Role for cingulate motor area cells in voluntary movement selection based on reward." Science.282. 1335-1338 (1998)

[Publications] Hoshi E.,Shima K.,& Tanji,J.: "Task-dependent selectivity of movement-related neuronal activity in the primate prefrontal cortex." J Neurophysiol.80. 3392-3397 (1998)

[Publications] Shima K.,& Tanji J.: "Both supplementary and presupplementary motor areas are crucial for the temporal organization of multiple movements." J Neurophysiol.80. 3247-3260 (1998)

[Publications] Kawashima R,Tanji J,Fukuda H,et.al: "Oculomotor sequence learning: a positron emission tomography study." Exp Brain Res.122. 1-8 (1998)

[Publications] Shima K,& Tanji,J.: "Involvement of NMDA and non-NMDA receptors in the neuronal responses of the primary motor cortec to input from the supplementary motor area and somatosensory cortex: studies of task-performing monkeys." Jpn J Physiol.48. 275-290 (1998)

[Publications] Fujii N.,Mushiake.,H.& Tanji,J.: "An oculomotor representation area within the ventral premotor cortex." Proc Natl Acad Sci U S A.95. 12034-12037 (1998)

[Publications] Fujii N.,Mushiake,H.& Tanji,J.: "Intracortical microstimulation of bilateral frontal eye field." J Neurophysiol.79. 2240-2244 (1998)

[Publications] 丹治順: "補足運動野と手の運動の順序制御" 神経進歩. 42. 29-38 (1998)

[Publications] 虫明元: "前補足運動野と手の運動のプランニング" 神経進歩. 42. 39-48 (1998)

[Publications] 平岡、吉澤: "多重化砂時計型ネットを用いた広いクラスの曲面によるデータフィッティング" 日本神経回路学会誌. 5. 3-9 (1998)

[Publications] 平岡、吉澤: "砂時計型ネットを用いた多価関数の学習" 電子情報通信学会論文誌. J81-D-II(11). 1653-1660 (1998)

[Publications] 寺田,田中,吉澤: "筋肉のHodgkin-Huxley方程式の2パラメータ分岐" 電子情報通信学会論文誌. J81-A(10). 1331-1338 (1998)

[Publications] Hiraoka,K.& Yoshizawa,S.: "Recalling of many-valued functions by successive iteration on" Proc.5th Internationaal Conf.on Neural Info.Proc.3. 1389-1392 (1998)

[Publications] Morinaga,S.& Yoshizawa,S.: "Control of spurious memories by usingself-coupling weight" Proc.5th Internationaal Conf.on Neural Info.Proc.3. 1389-1392 (1998)

[Publications] Watanabe K.,& Kimura M.: "Dopamine receptor-mediated mechanisms involved in the expression of learned activity of primate striate neurons." J Neurophysiol.79. 2568-2580 (1998)

[Publications] Kimura M,et.,al: "Potentiation of phosphoinositide-derived signals induced during LTP in rat intact brain." Neuro Report. 9. 2085-2088 (1998)

[Publications] Graybiel A M Kim u ra M.,et.,al: "Role of Nigrostriatal dopamine system in learning to perform sequential motor tasks in a predictive manner." in press. (1998)

[Publications] Graybiel AM and Kimura M.et.,al: "Neurons of CM and Pf in the thalamus supply striate neurons with multisensory information with alerting value." (submitted to J.Neurosci.). (1998)

[Publications] Wolpert D,Miall C,Kawato M: "Internal models in the cerebellum." Trends in Cognitive Sciences. 2. 338-347 (1998)

[Publications] Wolpert D,& Kawato M: "Multiple paired forward and inverse models for motor control." IEICE Trans.Fund.of Elec.Comn.Comp.Sci.E81-A. 1317-1329 (1998)

[Publications] Y.Sakumura & K.Aihara: "Stochastic Resonance by Modulation Detecting Neuron." Proc.of ICONIP 98. 2. 951-954 (1998)

[Publications] M.Watanabe,K.Aihara & S.Kondo: "A Dynamical Neural Net work with Temproal Coding and Functional Connectivity." Biol.Cybern. 78. 87-93 (1998)

[Publications] M.Watanabe & K.Aihara: "Chaos in Neural Networks Composed of Coincidence Detector Neurons." Neural Networks. 10. 1353-1359 (1998)

[Publications] Toyama,K & Yoshizawa,S.et.,al: "A new method for magnetoencephalography(MEG):Three dimensional magnetometer-spatial filter system." Neuroscience. 95(in press). (1998)

[Publications] Sakai,K.,Hikosaka,O.,Miyauchi,S.et.al: "Transition of brain activation from frontal to parietal areas in visuo-motor sequence learning." J.Neurosci.18. 1827-1840 (1998)

[Publications] Lu,X.,Hikosaka,O.,Miyachi,S.: "Role of monkey cerebellar nuclei in skill for sequential movement." J Neurophysiol.79. 2245-2254 (1998)

[Publications] Takino R,Hikosaka O.,Miyauchi,S.et.,al: "Separate cerebellar areas for motor control." NeuroReport. 9. 2359-2363 (1998)

[Publications] Kawagoe R,Takikawa Y.: "Expectation of reward modulates cognitive signals in the basal ganglia." Nat.Neurosci.1. 411-416 (1998)

[Publications] Shima K,& Tanji,J: "Involvement of NMDA and non-NMDA receptors in the neuronal responses of the primary motor cortex to input from the supplementary motor area and somatosensory cortex: studies of task-performing monkeys." Jpn J Physiol.48. 275-290 (1998)

[Publications] Nakamura K.,Sakai,K.,Hikosaka,O.: "Neuronal activity in medial frontal cortex during learning of sequential procedures." J.Neurophysiol.80. 2671-2687 (1998)

[Publications] Hikosaka O,Miyashita K.,: "Differential roles of the frontal cortex,basal ganglia,and cerebellum in visuomotor sequence learning." Neurobiology of Learning and Memory. 70. 137-149 (1998)

[Publications] Hikosaka,O.: "Neural systems for control of voluntary action-ahypothesis." Adv.Biophysics. 35. 81-102 (1998)

[Publications] Takikawa,Y.,Hikosaka,O.et.,al: "Presaccadicomnidirectional burst activity in the basal interstitial nucleus in the monkey cerebellum." Exp.Brain res.121. 442-450 (1998)

[Publications] 彦坂興秀: "手の順序動作の手続き的学習." 神経研究の進歩. 42. 106-116 (1998)

[Publications] Ikeda,H.,Nishijo,H.,Ono,T.et.,al: "Generators of visual evoked potentials investigated by dipole tracing in the human occipital cortec." Neurosci.84. 723-739 (1999)

[Publications] Fujii N.,Mushiake.,H.& Tanji,J.: "Active spatial information processing in the septo-hippocampal system." Hippocampus. in press. (1998)

[Publications] Yonemori,M.,Nishijo,H.,Ono,T.: "Orbital cortex neurinal responses during an odor-based conditioned associative task in rats." Neuroscience. in press. (1999)

[Publications] Kondo,T.,Ono,T.,anishijo,H.et.,al.: "Mechanisms of umami taste preference and aversion in rats." J.Nutrition. 35(in prss). (1999)

[Publications] Matsumura,N.,Nishijo,H.,Ono,T: "Spatial and task-dependent neuronal responses during real and virtual translocation in the monkey hippocampal formation." J.Neurosci. in press. (1999)

[Publications] 彦坂興秀: "手の順序動作の手続き的学習." 神経研究の進歩. 42. 106-116 (1998)

[Publications] Ikeda,H.,Nishijo,H.,Ono,T.et.al: "Generators of visual evoked potentials investigated by dipole tracing in the human occipital cortec." Neurosci.84. 723-739 (1999)

丹治順東北大学, 医学部, 教授 (10001885)