1999 Fiscal Year Annual Research Report

高次脳機能のシステム的理解

Research Project

Project/Area Number	08279101
Research Institution	Tohoku University
Principal Investigator	丹治順東北大学, 大学院・医学系研究科, 教授 (10001885)
Co-Investigator(Kenkyū-buntansha)	合原一幸東京大学, 工学部, 助教授 (40167218) 木村實大阪大学, 健康体育部, 教授 (40118451) 吉澤修治東京大学, 工学部, 教授 (90010959) 彦坂興秀順天堂大学, 医学部, 教授 (70120300) 小野武年富山医科薬科大学, 医学部, 教授 (50019577)
Keywords	高次脳機能 / 実験的神経科学 / 計算論的神経科学 / コンピュータシミュレーション / イメージング / 認知 / 行動 / 記憶
Research Abstract	脳の高次機能解明には、多面的なアプローチが必要である。この研究プロジェクトにおいては、生物を対象とした実験研究によって脳の高次機能の発現と制御の実態を明らかにしする研究グループと、脳の動作原理とシステム的な動作様式を理論的に解明する研究グループの研究協力によって、総合的な脳機能理解を目指すことを目的とした.そのために、実験的神経科学者、計算論的神経科学者、非襲侵的脳機能イメージングによる研究者から成る研究グループを組織し、それぞれの研究者が専門領域の研究を進めるだけではなく、ワークショップ・シンポジューム・研究会を数多く行って他領域の理解を進め、さらに学際的な共同研究を含めた研究協力を行なった。ニュースレター「高次脳機能のシステム的理解」を定期的に発行して研究者相互の研究理解促進をはかるとともに、コンピュータネットワークを形成し、独自のホームページを作成して、研究情報の迅速な連絡を行った。研究は全体的に順調に進捗し、具体的な成果が次々と得られるに至った。得られた研究成果は、脳機能の多くの側面に及んでいるが、なかでも運動の学習機構の解明、随意的行動選択における前頭連合野の機能解明、小脳細胞の動作原理に関する理論の実験的裏付け、側頭葉におけるメモリー依存的運動誘導機能の発見、海馬と海馬周辺皮質を流れる情報の実時間的イメージング、前頭葉ニューロンにおける報酬予測的活動の発見などが特に顕著な研究成果として挙げられる。これらはいずれも国際学会で発表し、国際的な学術専門誌に論文として掲載されるに至った。

Research Products

(18 results)

All Other

All Publications (18 results)

[Publications] Mushiake H, Fujii N, Tanji J: "Microstimulation of the lateral wall of the intraparietal sulcuscompared with the fronatal eye field during oculomotor tasks"J. Neurophysiol.. 81. 1443-1448 (1999)
[Publications] Sakai ST, Inase M, Tanji J.: "Pallidal and oerebellar inputs to thalamocortical neurons projecting to the supplementarymotor area in Macaca fuscata : a triple-labeling light microscopic study"Anat. Embryol.. 199. 9-19 (1999)
[Publications] Matsumoto N, Hanakawa T, Maki S, Graybiel AM, Kimura M: "Role of [corrected] nigrostriatal dopamine system in learing to perform sequential motor tasks in a predictive manner"J Neurophysiol. 82. 978-998 (1999)
[Publications] Watanabe K, Kimura M: "Dopamine receptor-mediated mechanisms involved in the expression of learned activity of primate striatal neurons"J Neurophysiol. 79. 2568-2580 (1999)
[Publications] Watanabe M, Aihara K, Kondo S: "A dynamic neural network with temporal coding and functional connectiveity"Biol Cybern. 78. 87-93 (1998)
[Publications] Ono T, Nishijo H: "Active spatial information processing in the septohippocampal system"Hippocampus. 9. 458-466 (1999)
[Publications] Matsumura N, Nishijo H, Tamura R, Eifuku S, Endo S, Ono T: "Spatial- and task-dependent neuronal responses during real and virtual translocation in the monkey hippocampal formation"J Neurosci. 19. 2381-2393 (1999)
[Publications] Hikosaka O: "Probing consciousness with an electrode"Brain Res Bull. 50. 337-338 (1999)
[Publications] Sakai K, Hikosaka O, Miyauchi S, Takino R, Tamada T, Iwata NK.: "Neural representation of a rhythm depends on its interval ratio"J Neurosci. 19. 10074-10081 (1999)
[Publications] Nakamura K, Sakai K, Hikosaka O: "Effects of local inactivation of monkey medial frontal cortex in learning of sequential procedures"J Neurophysiol. 82. 1063-1068 (1999)
[Publications] Higashi S, Crair MC, Kurotani T, Inokawa H, Tovama K: "Altered spatial patterns of functional thalamocortical connections in the barrel cortex after neonatal infraorbital nerve cut revealed by optical recordina"Neuroscience. 91. 439-452 (1999)
[Publications] Toyama K, Yoshikawa K, Yoshida Y, Kondo Y, Toma S, Takanashi Y, Ema Y, Yoshizawa S: "A new method for magnetoencephalography : a three-dimensional magnetometer-spatial filter system"Neuroscience. 91. 405-415 (1999)
[Publications] Imamizu H, Miyauchi S, Tamada T, Sasaki Y, Takino R, Rutz B, Yoshioka T, Kawato M: "Human cerebellar activity reflecting an acquired internal model of a new tool"Nature. 403. 192-195 (1999)
[Publications] Kawato M: "Internal models for motor control and trajectory planning"J Neurophysiol. 81. 2140-2155 (1999)
[Publications] Nakano E, Imamizu H, Osu R, Uno Y, Gomi H, Yoshioka T, Kawato M: "Quantitative examinations of internal representations for arm trajectory planning : minimum commanded torgue change model"Curr Opin Neurobiol. 9. 718-727 (1999)
[Publications] Aihara T, Tsukada M, Matsuda H: "Two dynamic precesses for the induction of long-term potentiation in hippocampal CA1 neurons"Biol Cybern. 82. 189-195 (2000)
[Publications] Sato H, Hata Y, Tsumoto T: "Effects of blocking non-N-methyl-D-aspartate receptors on visual responses of neurons in the cat visual cortex"Neuroscience. 94. 697-703 (1999)
[Publications] Yoshimura Y, Kimura F, Tsumoto T: "Estimation of single channel conductance underlying synaptic transmission between pyramidal cells in the visual cortex"Neuroscience. 88. 347-352 (1999)

1999 Fiscal Year Annual Research Report

高次脳機能のシステム的理解

Principal Investigator

丹治 順 東北大学, 大学院・医学系研究科, 教授 (10001885)

Research Products

[Publications] Mushiake H, Fujii N, Tanji J: "Microstimulation of the lateral wall of the intraparietal sulcuscompared with the fronatal eye field during oculomotor tasks"J. Neurophysiol.. 81. 1443-1448 (1999)

[Publications] Sakai ST, Inase M, Tanji J.: "Pallidal and oerebellar inputs to thalamocortical neurons projecting to the supplementarymotor area in Macaca fuscata : a triple-labeling light microscopic study"Anat. Embryol.. 199. 9-19 (1999)

[Publications] Matsumoto N, Hanakawa T, Maki S, Graybiel AM, Kimura M: "Role of [corrected] nigrostriatal dopamine system in learing to perform sequential motor tasks in a predictive manner"J Neurophysiol. 82. 978-998 (1999)

[Publications] Watanabe K, Kimura M: "Dopamine receptor-mediated mechanisms involved in the expression of learned activity of primate striatal neurons"J Neurophysiol. 79. 2568-2580 (1999)

[Publications] Watanabe M, Aihara K, Kondo S: "A dynamic neural network with temporal coding and functional connectiveity"Biol Cybern. 78. 87-93 (1998)

[Publications] Ono T, Nishijo H: "Active spatial information processing in the septohippocampal system"Hippocampus. 9. 458-466 (1999)

[Publications] Matsumura N, Nishijo H, Tamura R, Eifuku S, Endo S, Ono T: "Spatial- and task-dependent neuronal responses during real and virtual translocation in the monkey hippocampal formation"J Neurosci. 19. 2381-2393 (1999)

[Publications] Hikosaka O: "Probing consciousness with an electrode"Brain Res Bull. 50. 337-338 (1999)

[Publications] Sakai K, Hikosaka O, Miyauchi S, Takino R, Tamada T, Iwata NK.: "Neural representation of a rhythm depends on its interval ratio"J Neurosci. 19. 10074-10081 (1999)

[Publications] Nakamura K, Sakai K, Hikosaka O: "Effects of local inactivation of monkey medial frontal cortex in learning of sequential procedures"J Neurophysiol. 82. 1063-1068 (1999)

[Publications] Higashi S, Crair MC, Kurotani T, Inokawa H, Tovama K: "Altered spatial patterns of functional thalamocortical connections in the barrel cortex after neonatal infraorbital nerve cut revealed by optical recordina"Neuroscience. 91. 439-452 (1999)

[Publications] Toyama K, Yoshikawa K, Yoshida Y, Kondo Y, Toma S, Takanashi Y, Ema Y, Yoshizawa S: "A new method for magnetoencephalography : a three-dimensional magnetometer-spatial filter system"Neuroscience. 91. 405-415 (1999)

[Publications] Imamizu H, Miyauchi S, Tamada T, Sasaki Y, Takino R, Rutz B, Yoshioka T, Kawato M: "Human cerebellar activity reflecting an acquired internal model of a new tool"Nature. 403. 192-195 (1999)

[Publications] Kawato M: "Internal models for motor control and trajectory planning"J Neurophysiol. 81. 2140-2155 (1999)

[Publications] Nakano E, Imamizu H, Osu R, Uno Y, Gomi H, Yoshioka T, Kawato M: "Quantitative examinations of internal representations for arm trajectory planning : minimum commanded torgue change model"Curr Opin Neurobiol. 9. 718-727 (1999)

[Publications] Aihara T, Tsukada M, Matsuda H: "Two dynamic precesses for the induction of long-term potentiation in hippocampal CA1 neurons"Biol Cybern. 82. 189-195 (2000)

[Publications] Sato H, Hata Y, Tsumoto T: "Effects of blocking non-N-methyl-D-aspartate receptors on visual responses of neurons in the cat visual cortex"Neuroscience. 94. 697-703 (1999)

[Publications] Yoshimura Y, Kimura F, Tsumoto T: "Estimation of single channel conductance underlying synaptic transmission between pyramidal cells in the visual cortex"Neuroscience. 88. 347-352 (1999)

丹治順東北大学, 大学院・医学系研究科, 教授 (10001885)