1999 Fiscal Year Annual Research Report

行動の選択・決定と運動の戦略に関する神経機構の研究

Research Project

Project/Area Number	08279106
Research Institution	Osaka University
Principal Investigator	木村實大阪大学, 健康体育部, 教授 (40118451)
Co-Investigator(Kenkyū-buntansha)	川人光男 ATR人間情報通信研究所, 室長彦坂興秀順天堂大学, 医学部・第一生理学, 教授 (70120300) 丹治順東北大学, 医学部・生体システム生理学, 教授 (10001885) 水野昇東京都神経科学総合研究所, 所長 (10025596) 柴崎浩京都大学, 医学部, 教授 (30037444)
Keywords	行動 / 運動 / 順序運動 / モデル / 手続き学習 / 運動学習 / 運動の記憶 / 機能的MRI
Research Abstract	木村は、運動や行動の学習と記憶の仕組みにおいて大脳基底核がどのような役割を担うかを調べるために、一側の黒質線条体ドーパミン系を破壊したサルに、左右の手を用いて複数のボタン押し運動を学習させた。その結果、大脳基底核は複数のボタン押し運動を予測的で、スムースな一連の運動として学習する上で必須であり、その仕組みに黒質線条体ドーパミン系が重要な役割を担うことを明らかにした。丹治は、運動発現における運動前野の機能を明らかにするための研究を行った。背側、および腹側運動前野の細胞は運動の順序制御に関わる補足運動野の細胞と異なり、行うべき運動の種類(押す、引く、回す)を表現するものが多いことが判明した。また、皮質内微小刺激によって手の運動のみならず眼球の運動が誘発される部位も多く、手と眼球の運動との協調に関与することが示唆された。彦坂は、手続き的学習の成立とその記憶の神経機構を調べる研究を行い、以下の結論を得た。前補足運動野は新しい順序の学習において刺激と運動の連合を学習することに関わるが、学習済みの運動の発現には関与しない。手続き的学習と記憶の機構は、大脳皮質前頭葉、大脳基底核と小脳を含む回路で達成されることをネットワークモデルで示した。川人は、感覚運動統合の学習を説明するモデルとして、「階層的多順逆対モデル」を提唱していたが、そのモデルはコミュニケーション信号の生成の神経回路を使って運動やコミュニケーション信号の認知が行えることを示した。笠井は、直線運動時の補償性眼球運動の基本的な性質を明らかにするために、人を対象として心理物理学的な研究を行った。水野は、線条体の投射ニューロンを免疫学的に識別する手段を開発し、黒質投射ニューロンと淡蒼球投射ニューロンに加えて、無名質に投射するニューロンの存在を発見した。これらは、Preprotachykininをを産成しており、ドーパミン支配を受けないことも示唆された。。臼井は、網膜での視覚情報処理を実現する神経機構を解明するために、on型杆体双極細胞の細胞体-シナプス終末間の伝達特性の解析と、神経節細胞のイオン電流モデルについて研究した。

Research Products

(25 results)

All Other

All Publications (25 results)

[Publications] Matsumoto, N., Hanakawa, T., Maki, S., Graybiel, A. M., and Kimura, M.: "Role of nigrostriatal dopamine system in learning to perform sequential motor tasks in a predictive manner"J. Neurophysiol.. 82. 978-998 (1999)
[Publications] 132. Mushiake H., Fujii N., Tanji J.: "Microstimulation of the lateral wall of the intraparietal sulcus compared with the frontal eye field during oculomotor tasks"J Neurophysiol. 81. 1443-1448 (1999)
[Publications] akamura K., Sakai K., Hikosaka O.: "Effects of local inactivation of monkey medial frontal cortex in learning of sequential procedures"J Neurophysiol. 82. 1063-1068 (1999)
[Publications] Sakai K., Hikosaka O., Miyauchi S., Sasaki Y., Fujimaki N., Puetz: "Pre-SMA activation during sequence learning reflects visuo-motor association"J Neurosci. 19. 1-6 (1999)
[Publications] Sakai K., Hikosaka O., Miyauchi S., Takino R., Tamada T., Iwata NK., Nielsen M.: "Neural representation of a rhythm depends on its interval ratio"J Neurosci. 19. 10074-10081 (1999)
[Publications] Hikosaka O., Sakai K., Nakahara H., Lu X., Miyachi S., Nakamura K., Rand M.K.: "Neural mechanisms for learning of sequential procedures"The New Cognitive Neurosciences. 553-572 (1999)
[Publications] Hikosaka O., Nakahara H., Rand M.K., Sakai K., Lu X., Nakamura K., Miyachi S., Doya K.: "Parallel neural networks for learning sequential procedures"Trends Neurosci. 22. 464-471 (1999)
[Publications] haruno, M., Wolpert, D., and Kawato, M.: "M. Multiple paired forward-inverse models for human motor learning and control"Advances in Neural Information Processing Systems. 11. 31-37 (1999)
[Publications] Kawato, M.: "Internal models for motor control and trajectory planning"Current Opinion in Neurobiology. 9. 718-727 (1999)
[Publications] 川人光男: "小脳多重内部モデル仮説:感覚運動統合からコミュニケーションへ"ATR technical Report. TR-H-271. 1-24 (1999)
[Publications] 162. Schweighofe-N ; Doya-K ; Kawato-M.: "Electrophysiological properties of inferior olive neurons : A compartmental model"J-Neurophysiol.. 82・2. 804-817 (1999)
[Publications] 163. Watanabe-H ; Polick-FE ; Koenderink-JJ ; Kawato-M.: "Using motor tasks to quantitatively judge 3-D surface curvatures"Percept-Psychophys. 61・6. 1116-1139 (1999)
[Publications] 164. Nakano-E ; Imamizu-H ; Osu-R ; Uno-Y ; Comi-H ; Yoshioka-T ; Kawato-M.: "Quantitative examinations of internal representations for arm trajectory planning : minimum commanded torque change model"J-Neurophysiol. 81・5. 2140-2155 (1999)
[Publications] 165. Tamada-T ; Miyauchi-S ; Imamizu-H ; Yoshioka-T ; Kawato-M.: "Cerebro-cerebellar functional connectivity revealed by the laterality index in tool-use learning"Neuroreport. 10・2. 325-331 (1999)
[Publications] 166. Hiroshi Imamizu, Satou Miyauchi, Tomoe Tamada, Yuka Sasaki, Ryousuke Takino, Benno P*z, Toshinori Yoshioka, Mitsuo Kawato: "Human cerebellar activity reflecting an acquired internal model of anew tool"Nature. 403・13. 1458-1468 (1999)
[Publications] Toma, K., Honda, M., Hanakawa, T, Okada, T., Fukuyama, H., Ikeda, A., Nishizawa, S., Konishi, J., and Shibasaki, H.: "Activities of the primary and supplementary motor areas increase in preparation and execution of voluntary muscle relaxation : an event-related fMRI study"J Neurosci.. 19. 3257-3534 (1999)
[Publications] Ikeda, A., Yazawa S., Kunieda, T., Ohara, S., Terada, K., Mikuni, N., Nagamine, T., Taki, W., Kimura, J., and Shibasaki, H.: "Cognitive motor control in human pre-supplementary motor area studied by subdural recording of decrimunation/selection-related cortical potentials"Brain. 122. 915-931 (1999)
[Publications] Ikeda, A., Taki, W., Kunieda, T., Terada, K., Mikuni, N., Nagamine, T., Yazawa, S., Ohara, S., Hori, T., Kaji, R., Kimura, J. and Shibasaki, H.: "Focal ictal DC shifts in humanepilepsy as studied by subdural and scalp recording"Brain. (in press).
[Publications] Ikeda, A., Yazawa, S., Kunieda, T., Ohara, S., Terada, K., Mikuni, N., Nagamine, T., Taki, W., Kimura, J. and Shibasaki, H.: "Congnitive motor control in human pre-supplementary motor area studied by subdural recording of decrimunation/selection-related cortical potentials"Brain. (in press).
[Publications] Yazawa, S., Ikeda, A., Kunieda, T., Ohara, S., Mima, T., Nagamine, T.,Taki, W., Hori, T., and Shibasaki, H.: "Human pre-supplementary motor area is active before voluntary movement : subdural recording of Bereitschaftspotentials from mesial frontal cortex"Exp Brain Res. (in press).
[Publications] Ohara, S., Ikeda, A., Kunieda, T., Yazawa, S., Baba, K., Nagamine, T., Taki, W., Hashimoto, N., Mihara, T., and Shibasaki, H.: "Movement-related oscillatory change in human SMA proper"Brain. (in press).
[Publications] Ikeda, A., Ohara, S., Matsumoto, R., Kunieda, T., Nagamine, T., Miyamoto, S., Kohara, N., Taki, W., Hashimoto, N., and Shibasaki, H.: "Role of primary sensorimotor cortices in generating inhibitory motor response in humans"Brain. (in press).
[Publications] 疋田真一、笠井健: "頭部直線運動時の補償性眼球運動について"電子情報通信学会技術研究報. MBE99-26. (1999)
[Publications] Kamiyama, Y., Aoyama, T., Usui, S.: "Analysis of the spatio-temporal charactereistics of the rod"Society For Neuroscience 29th annual meeting. 1431 (1999)
[Publications] Usui, S., Kamiyama, Y., Ishii, H., Ofura, T., Ishihara, A.: "Ionic current model of the outer retinal cells"Modeling in the Neurosciences. 293-319

1999 Fiscal Year Annual Research Report

行動の選択・決定と運動の戦略に関する神経機構の研究

Principal Investigator

木村 實 大阪大学, 健康体育部, 教授 (40118451)

Research Products

[Publications] Matsumoto, N., Hanakawa, T., Maki, S., Graybiel, A. M., and Kimura, M.: "Role of nigrostriatal dopamine system in learning to perform sequential motor tasks in a predictive manner"J. Neurophysiol.. 82. 978-998 (1999)

[Publications] 132. Mushiake H., Fujii N., Tanji J.: "Microstimulation of the lateral wall of the intraparietal sulcus compared with the frontal eye field during oculomotor tasks"J Neurophysiol. 81. 1443-1448 (1999)

[Publications] akamura K., Sakai K., Hikosaka O.: "Effects of local inactivation of monkey medial frontal cortex in learning of sequential procedures"J Neurophysiol. 82. 1063-1068 (1999)

[Publications] Sakai K., Hikosaka O., Miyauchi S., Sasaki Y., Fujimaki N., Puetz: "Pre-SMA activation during sequence learning reflects visuo-motor association"J Neurosci. 19. 1-6 (1999)

[Publications] Sakai K., Hikosaka O., Miyauchi S., Takino R., Tamada T., Iwata NK., Nielsen M.: "Neural representation of a rhythm depends on its interval ratio"J Neurosci. 19. 10074-10081 (1999)

[Publications] Hikosaka O., Sakai K., Nakahara H., Lu X., Miyachi S., Nakamura K., Rand M.K.: "Neural mechanisms for learning of sequential procedures"The New Cognitive Neurosciences. 553-572 (1999)

[Publications] Hikosaka O., Nakahara H., Rand M.K., Sakai K., Lu X., Nakamura K., Miyachi S., Doya K.: "Parallel neural networks for learning sequential procedures"Trends Neurosci. 22. 464-471 (1999)

[Publications] haruno, M., Wolpert, D., and Kawato, M.: "M. Multiple paired forward-inverse models for human motor learning and control"Advances in Neural Information Processing Systems. 11. 31-37 (1999)

[Publications] Kawato, M.: "Internal models for motor control and trajectory planning"Current Opinion in Neurobiology. 9. 718-727 (1999)

[Publications] 川人光男: "小脳多重内部モデル仮説:感覚運動統合からコミュニケーションへ"ATR technical Report. TR-H-271. 1-24 (1999)

[Publications] 162. Schweighofe-N ; Doya-K ; Kawato-M.: "Electrophysiological properties of inferior olive neurons : A compartmental model"J-Neurophysiol.. 82・2. 804-817 (1999)

[Publications] 163. Watanabe-H ; Polick-FE ; Koenderink-JJ ; Kawato-M.: "Using motor tasks to quantitatively judge 3-D surface curvatures"Percept-Psychophys. 61・6. 1116-1139 (1999)

[Publications] 164. Nakano-E ; Imamizu-H ; Osu-R ; Uno-Y ; Comi-H ; Yoshioka-T ; Kawato-M.: "Quantitative examinations of internal representations for arm trajectory planning : minimum commanded torque change model"J-Neurophysiol. 81・5. 2140-2155 (1999)

[Publications] 165. Tamada-T ; Miyauchi-S ; Imamizu-H ; Yoshioka-T ; Kawato-M.: "Cerebro-cerebellar functional connectivity revealed by the laterality index in tool-use learning"Neuroreport. 10・2. 325-331 (1999)

[Publications] 166. Hiroshi Imamizu, Satou Miyauchi, Tomoe Tamada, Yuka Sasaki, Ryousuke Takino, Benno P*z, Toshinori Yoshioka, Mitsuo Kawato: "Human cerebellar activity reflecting an acquired internal model of anew tool"Nature. 403・13. 1458-1468 (1999)

[Publications] Ikeda, A., Taki, W., Kunieda, T., Terada, K., Mikuni, N., Nagamine, T., Yazawa, S., Ohara, S., Hori, T., Kaji, R., Kimura, J. and Shibasaki, H.: "Focal ictal DC shifts in humanepilepsy as studied by subdural and scalp recording"Brain. (in press).

[Publications] Yazawa, S., Ikeda, A., Kunieda, T., Ohara, S., Mima, T., Nagamine, T.,Taki, W., Hori, T., and Shibasaki, H.: "Human pre-supplementary motor area is active before voluntary movement : subdural recording of Bereitschaftspotentials from mesial frontal cortex"Exp Brain Res. (in press).

[Publications] Ohara, S., Ikeda, A., Kunieda, T., Yazawa, S., Baba, K., Nagamine, T., Taki, W., Hashimoto, N., Mihara, T., and Shibasaki, H.: "Movement-related oscillatory change in human SMA proper"Brain. (in press).

[Publications] Ikeda, A., Ohara, S., Matsumoto, R., Kunieda, T., Nagamine, T., Miyamoto, S., Kohara, N., Taki, W., Hashimoto, N., and Shibasaki, H.: "Role of primary sensorimotor cortices in generating inhibitory motor response in humans"Brain. (in press).

[Publications] 疋田真一、笠井健: "頭部直線運動時の補償性眼球運動について"電子情報通信学会技術研究報. MBE99-26. (1999)

[Publications] Kamiyama, Y., Aoyama, T., Usui, S.: "Analysis of the spatio-temporal charactereistics of the rod"Society For Neuroscience 29th annual meeting. 1431 (1999)

[Publications] Usui, S., Kamiyama, Y., Ishii, H., Ofura, T., Ishihara, A.: "Ionic current model of the outer retinal cells"Modeling in the Neurosciences. 293-319

木村實大阪大学, 健康体育部, 教授 (40118451)