1998 Fiscal Year Final Research Report Summary
QUANTITATIVE ANALYSIS OF MYOCARDIAL PERFUSION AND METABOLISM USING SPECT
| Project/Area Number |
08407023
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
TAMAKI Nagara School of Medicine, Hokkaido University, Pro., 医学部, 教授 (30171888)
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| Co-Investigator(Kenkyū-buntansha) |
KITABATAKE Akira School of Medicine, Hokkaido University, Pro., 医学部, 教授 (00124769)
MIYASAKA Kazuo School of Medicine, Hokkaido University, Pro., 医学部, 教授 (60001939)
TSUKAMOTO Eriko School of Medicine, Hokkaido University, Asso.Pro., 医学部, 講師 (40201636)
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| Project Period (FY) |
1996 – 1998
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| Keywords | emission tomography / myocardium / myocardial blood flow / metabolism / 1-123 BMIPP / Tc-99m sestamibi |
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| Research Abstract |
1.A new workstation with a recently developed algorithm was installed to perform three-dimensional image co-registration of SPECT images with other anatomical images using CT or MRI.This image co-registration was useful to differentiate actual hypoperfusion from the artifacts due to partial volume effect on the brain SPECT studies. Such image fusion analysis is considered to be valuable for precise evaluation of myocardial perfusion and function in various cardiac diseases.
2. ECG-gated myocardial perfusion SPECT has recently been applied for simultaneous evaluation of regional perfusion and function. This new technique was valuable for assessing pathophysiology in patients with complete left bundle branch block and risk stratification in patients suspected with coronary artery disease.
3. Assessment of regional myocardial metabolism in vivo has been performed with use of iodinated fatty acid compound, BMIPP.In the follow-up study of patients with acute myocardial infarction, the perfusion SPECT was applied to estimate the area at risk, infarcted myocardium, and salvaged myocardium. Since metabolic recovery was slower than the perfusion recovery after revascularization therapy, BMIPP-SPECT at one week after infarction was valuable for estimating the area at risk. Furthermore, BMIPP imaging was used for identifying metabolic abnormalities in hypertrophic myocardium in the spontaneous hypertensive rat model and patients with hypertrophic cardiomyopathy. Metabolic alterations preceded perfusion abnormalities in these myocardial disorders. Thus, the combined imaging of perfusion and metabolism with SPECT may provide insight in to pathophysiology in various myocardial disorders.
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Research Products
(18 results)
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[Publications] Tadamura, E., Tamaki, N., Matsumori, A., Magata, Y., Yonekura, Y., Nohara, R., Sasayama, S., Yoshibayashi, M., Kamiya, T., Konishi, J.: "Myocardial metabolic changes in hypertrophic cardiomyopathy." J Nucl Med. 37 (4). 572-577 (1996)
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「研究成果報告書概要(欧文)」より
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[Publications] Fujibayashi, Y., Nohara, R., Hosokawa, R., Okuda, K., Yonekura, Y., Tamaki, N., Konishi, J., Sasayama, S., Yokoyama, A.: "Metabolism and kinetics of iodine-123-BMIPP in canine myocardium." J Nucl Med. 37 (5). 757-761 (1996)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Nohara, R., Okuda, K., Ogino, M., Hosokawa, R., Tamaki, N., Konishi, J., Fujibayashi, Y., Yonekura, Y., Fujita, M., Sasayama, S.: "Evaluation of myocardial viability with iodine-123-BMIPP in a canine model." J Nucl Med. 37 (8). 1403-1407 (1996)
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「研究成果報告書概要(欧文)」より
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[Publications] Hosokawa, R., Nohara, R., Fujibayashi, Y., Okuda, K., Ogino, M., Hata, T., Fujita, M., Tamaki, N., Konishi, J., Sasayama, S.: "Myocardial kinetics of iodine-123-BMIPP in canine myocardium after regional ischemia and reperfusion : Implications for clinical SPECT." J.Nucl.Med.38 (12). 1857-1863 (1997)
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「研究成果報告書概要(欧文)」より
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[Publications] Sugihara, H., Tamaki, N., Nozawa, M., Ohmura, T., Inamoto, Y., Taniguchi, T., Aoki, E., Mitsunami, K., Kinoshita, M.: "Septal perfusion and wall thickening in patients with left bundle branch block Assessed by technetium-99m-sestamibi gated tomography." J.Nucl.Med.38 (4). 545-547 (1997)
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「研究成果報告書概要(欧文)」より
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[Publications] Mochizuki, T., Tsukamoto, E., Ono, T., Kanegae, K., Katoh, C., Shiga, T., Nakada, K., Kohya, T., Tamaki, N.: "Sequential change of BMIPP uptake with age in spontaneously hypertensive rat model." Ann.Nucl.Med.11 (4). 299-306 (1997)
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「研究成果報告書概要(欧文)」より
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[Publications] Tadamura, E., Kudoh, T., Hattori, N., Inubushi, M., Magata, Y., Konishi, J., Matsumori, A., Nohara, R., Sasayama, S., Yoshibayashi, M., Tamaki, N.: "Impairment of BMIPP uptake precedes abnormalities in oxygen and glucose metabolism in hypertrophic cardiomyopathy." J.Nucl.Med.39 (3). 390-396 (1998)
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「研究成果報告書概要(欧文)」より
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[Publications] Kawai, Y., Tsukamoto, E., Nozaki, Y., Kishino, K., Kohya, T., Tamaki, N.: "Use of 123I-BMIPP single-photon emission tomography to estimate areas at risk following successful revascularization in patients with acute myocardial infarction." Eur.J.Nucl.Med.25 (10). 1390-1395 (1998)
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「研究成果報告書概要(欧文)」より
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