1998 Fiscal Year Final Research Report Summary
Peripheral circulatory disturbance and cytokines in vibration syndrome
| Project/Area Number |
08457130
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Tottori University |
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Principal Investigator |
NOSE Takayuki Department of Public Health, Faculty of Medicine, Tottori University, Professor, 医学部, 教授 (10032195)
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| Co-Investigator(Kenkyū-buntansha) |
IWAI Nobuo Department of Public Health, Faculty of Medicine, Tottori University Assistant, 医学部, 助手 (80191906)
KUROZAWA Youichi Department of Public Health, Faculty of Medicine, Tottori University, Instructor, 医学部, 助手 (50161790)
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| Project Period (FY) |
1996 – 1998
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| Keywords | cytokine / adhesion molecules / vibration syndrome |
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| Research Abstract |
1) Eleven healthy subjects were exposed to vibration (100Hz 10min).We investigated levels of TNF, IL-1, sE-selectin, sICAM-1 and sVCAM-1 in serum before and after exposure of vibration. No significant increases of them were found.
2) We investigated whether a relationship existed between soluble adhesion molecules and vascular damage from vibration-induced white finger (VWF). Twenty-five vibration exposed men and 23 normal healthy men as controls were examined. Concentrations of sE-selectin, sICAM- 1 and sVCAM-1 in serum were measured by the sandwich ELAISA method. Soluble VCAM-1, neither sE-selectin nor sICAM-1, was elevated in vibration-exposed men with VWF compared with those in vibration-exposed men without VWF and controls.
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