1998 Fiscal Year Final Research Report Summary
BASICAND CLINICAL RESEARCH ON CONCURRENT CHEMORADIOTHERAPY WITH PROTRACTED LOW DOSE CONTINUOUS INFUSION OF 5-FU + CDDP FOR ESOPHAGEAL CANCER
| Project/Area Number |
08457240
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | NIIGATA UNIVERSITY |
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Principal Investigator |
SAKAI Kunio NIIGATA UNIV.SCHL.OF MED.PROF., 医学部, 教授 (20018378)
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| Co-Investigator(Kenkyū-buntansha) |
OHKUBO Masaki NIIGATA UNIV.BIOMED.COLL.ASS.PROF, 医療技術短期大学部, 助教授 (10203738)
MATSUMOTO Yasuo NIIGATA UNIV.MED.HOSP.ASSISTANT, 医学部附属病院, 助手 (20303159)
TSUCHIDA Emiko NIIGATA UNIV.SCHL OF MED.ASSISTANT, 医学部, 助手 (70210630)
SUGITA Tadashi NIIGATA UNIV.MED.HOSP.LECTURER, 医学部附属病院, 講師 (60216314)
FUJITA Shozo NIIGATA UNIV.BIOMED.COLL.PROF., 医療技術短期大学部, 教授 (90080100)
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| Project Period (FY) |
1996 – 1998
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| Keywords | CHEMORADIOTHERAPY / ESOPHAGEAL CANCER / 5-FU / DDDP |
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| Research Abstract |
In the basic study using flow cytometry, a pronounced G_2M phase accumulation of FM3A cells was observed at 72 hours after the combined treatment of 5-FU and CDDP, Most of the cells blocked in G_2 phase for a long time became giant cells or multinuclear cells, which seemed todie later. Combining 5-FU plus CDDP with radiation showed synergistic cytotoxic effect on the experiments using cell growth analysis, dye exclusion test, and morphological analysis.
In the clinical study, 31 patients with stage II - III esophageal cancer treated between 1992 and 1994 with the concurrent chemoradiotherapy using low-dose continuous infusion of 5-PU (RT+5FU group) were compared with 27 patients treated previously with radiotherapy alone (RT group). Response rate and local-progression free rate of the RT+5FU group were sigificantly higher than the RT group (p<0.05). Since 1995.32 patients with stage II - III esophageal cancer were treated with the concurrent chemoradiotherapy using low-dose continuous infusion of 5-FU (250 rng/m^2/day) plus CDDP (3 mg/m^2/day) (RTFC group). The RT+FC group showed response rate, local-progression free rate, and cummulative survival rate to be significantly higher than the RT group (p<0.05). We conclude that low-dose continuous infusion of 5-FU*CCDDP given during entire course of conventional radiotherapy is significantly superior to conventional radiotherapy alone in the local control of stage II - III esophageal cancer.
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