1998 Fiscal Year Final Research Report Summary
The experimental study of long-term heart preservation with the combined method of simple immersion and coronary perfusion through the new technique for the evaluation of cardiac function using force transducer
| Project/Area Number |
08457345
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Gunma University School of Medicine |
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Principal Investigator |
MORISHITA Yasuo Gunma University School of Medicine, Second Department of Surgery, Professor and Chairmen, 医学部, 教授 (40145470)
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| Co-Investigator(Kenkyū-buntansha) |
SAKATA Kazuhiro Gunma University School of Medicine, Second Department of Surgery, Assistant, 医学部, 助手 (10302473)
ISHIKAWA Susumu Gunma University School of Medicine, Second Department of Surgery, Assistant Pro, 医学部, 講師 (90241877)
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| Project Period (FY) |
1996 – 1998
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| Keywords | simple immersion / soronary perfusion / heart preservation / heart transplantation / cardiac function / force transducer |
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| Research Abstract |
In our previous study, the donor heart was well preserved by the combined method of 12-hr simple immersion and 1-hr coronary perfusion. The efficacy of diluted blood was confirmed as perfusate for coronary perfusion compared with the University of Wisconsin (UW) solution. In addition, we designed an original apparatus for continuous coronary perfusion preservation instead of the Langendorff's method This apparatus has such characteristics as hypothermic management, variable perfusion pressure, non-dependent energy source and portable. We reported the usefulness of this apparatus in canine models through 12-hr preservation followed by orthotopic transplantation. We are now planning the evaluation of transplanted hearts by the force transducer and long-term heart preservation of more than 12-hr.
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[Publications] Hasegawa Y,Suzuki M,Ohtaki A,Takahashi T,Sato S,Iwanami K,Yamagishi T,Oshima K,Ishikawa S,Kanda T,Morishita Y: "Effects of short-term coronary perfusion after cold storage for long-term heart preservation : A comparative study of University of Wisconsin solution and diluted blood as the perfusate." Transplant Proc. 30. 3772-3773 (1998)
Description
「研究成果報告書概要(欧文)」より
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