1998 Fiscal Year Final Research Report Summary
Total Synthesis and Determination of Absolute Configuration of Carthamin ; A Red Pigment in the Petals of Safflower
| Project/Area Number |
08651016
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | YAMAGATA UNIVERSITY |
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Principal Investigator |
SATO Shingo Faculty of Engineering, Associate Professor, 工学部, 助教授 (30215793)
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| Co-Investigator(Kenkyū-buntansha) |
ONODERA Jun-ichi Faculty of Engineering, Professor, 工学部, 教授 (30007017)
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| Project Period (FY) |
1996 – 1998
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| Keywords | Coloring components of Safflower Petals / X-ray crystallographic analysis / CD Spectra / Biosynthetic Pathway / Absolute Configuration / C-glucosylquinochalcone / Wasabidienone A / Phoma wasabidiae |
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| Research Abstract |
Absolute configuration of Carthamin which is the red coloring component of safflower petals, was determined to be S, S.Furthermore, absolute configurations of the other yellow coloring components in which carthamin precursor, safflower yellow B, safflomin A, Safflomin C, and isosafflomin C bear C-glucosylquinochalcone as a common structural unit, were also determined to be S, S in the same way. Model compound of safflower yellow B which includes a chain-type glucose was first synthesized and its hydrolysis produced a small amount of carthamin-model compounds, as well as carthamin's biosynthetic pathway.
Next, we first synthesized Wasabidienone A which is one of the metabolites of phoma wasabidiae, highly oxidized structure, and a mixture of keto-enol tautomers like carthamin.
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