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1997 Fiscal Year Final Research Report Summary

Endocrine cell tumors of gastrointestinal tract : molecular biological study of their histogenesis progression, and metastasis

Research Project

Project/Area Number 08670195
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionNiigata University

Principal Investigator

IWAFUCHI Mitsuya  Niigata University, College of Biomedical Technology, Department of Medical Technology, Professor (Pathology), 医療技術短期大学部, 教授 (70143766)

Co-Investigator(Kenkyū-buntansha) SIGENO Naoya  Niigata University, College of Biomedical Technology, Department of Medical Tech, 医療技術短期大学部, 教授 (60018330)
WATANABE Hidenobu  Niigata University, School of Medicine, Department of Pathology, Professor (Path, 医学部, 教授 (70037381)
Project Period (FY) 1996 – 1997
KeywordsCarcinoid / Endocrine cell carcinoma / Small cell carcinoma / Paraneuroma / Gut hormone / Cell culture
Research Abstract

During the period of past two years of this project, about 400 gastrointestinal endocrine cell tumors (GECT) of Japanese and six cell lines of endocrine cell carcinoma were analyzed.
1. CLASSIFICATION : GECT were divided into two main groups : carcinoid tumor (CD), low-grade malignancy and endocrine cell carcinoma (ECC), high-grade malignacy.Histological differential diagnosis and the new classification according to ocurring sites of GECT were established.
2. HISTOGENESIS : CD was suspected to be mainly derived from immature endocrine cell. ECC was hypothesized to derive from neoplastic endocrine cell in mucosal tubular adenocarcinoma/adenoma, totipotential stem cell, CD,or immature endocrine cell. The first pathway was suspected to be most frequent, followed by the second. Difference in p53 protein overexpression between CD and ECC confirmed the difference in their histogenetic pathway.
3. PROGRESSION AND METASTASIS : Cell proliferation activity of GECT was confirmed to correlate well with tumor progression and metastasis. For clinical hormone analysis to assess tumor recurrence and metastasis, GECT should be subdivided into three groups ; argentaffin (serotonin-producing) CD,argyrophi1 (peptide-producing) CD,and ECC (frequently serotonin-producing).
4. CELL LINES : Four cell lines established from human esophageal, gastric and rectal ECC well preserved hormone (serotonin, peptide YY,calcitonin)-production. One esophageal cell line was effected by Vincristin and Mitomycin.

  • Research Products

    (64 results)

All Other

All Publications (64 results)

  • [Publications] 岩渕 三哉: "消化管内分泌細胞腫瘍群の産生ホルモンの特徴とホルモン検索の手順" 消化器科. 22. 358-365 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岩渕 三哉: "多発早期胃癌の特徴と診断-切除胃よりみて" 日本臨牀. 54. 1217-1223 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岩渕 三哉: "消化管カルチノイド腫瘍-最近の考え方" 外科. 58. 1305-1312 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岩渕 三哉: "臨床検査と形態学" 新潟大学学報. 606. 1- (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Watanabe H: "The pathological seguence in the plevelopment of gastric cancer : II" Scaol J Gastroentarol. 31. 36-39 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 渡辺 英伸: "食道 dysplasia(異形成)の組織診断" 胃と腸. 31. 705-709 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 渡辺 英伸: "Helicobater pyloriと胃リンパ腫" 胃と腸. 31. 943-944 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yagi K: "A minute rectal carcinoma with massive submucasal invasion and lymph-mode metastasis" Endosiopy. 28. 161- (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakagawa S: "Archival analysis of p53 protein ovevexpression and genetic mutation in esophageal squamous cell caroinon" Acta Meolica et Biologica. 44. 63-69 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kudo S: "Diagnosis of colorectal tumorous lesions by magnitying endoscopy" Gastrointestinal Enolosiopy. 44. 8-14 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Serra I: "Gallblaolder carcinoma : case control study in chile" Chilena cirugia. 48. 139-147 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nishimaki T: "Early esophageal adenocaroinoma arising in a short segment of Barrett's muoosa" Am J Gastrol. 91. 1856-1857 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kobayashi M: "Effect of K-ras mutation on morphogenesis of colorectal adenomas and early cancers" Human Pathol. 27. 1042-1049 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Dixon MF: "Classification and graoling of gastritis" Am J Snig Pathol. 20. 1161-1181 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsuda K: "Ulcerative colotic with overexpression of p53 preceding overt histological abnormalities of the opithelium" J Gastroenteol. 31. 860-867 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mano H: "Comparison of mutagenic activity of bile between chilean and Japanese female patients having cholelithiasis" Mutation Reseaech. 371. 73-77 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 山田 尚志: "MRIが有用であった胃平滑筋芽細胞腫の1例" Endoscopic Forum for Digestive Disease. 12. 74-78 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 何汝朝: "多彩な内視鏡像を呈した早期胃腺扁平上皮癌の1例" 胃と腸. 31. 913-918 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 成沢 林太郎: "Helicobacter pylori 除菌療法後の胃MALTリンパ腫と濾胞性胃炎の形態変化" 胃と腸. 31. 965-972 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松田 圭二: "潰瘍性大腸炎の癌化-免疫組織化学の立場から" 医学のあゆみ. 178. 622-629 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松田 圭二: "早期大腸がんとP53遺伝子異常" 最新医学. 51. 1408-1421 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 山口 孝太郎: "Helicohaiter pyloriの除菌療法により改善が認められた胃MALTリンパ腫の1例" 胃と腸. 31. 1019-1025 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松田 圭二: "虫垂カルチノイド" 外科. 58. 1335-1341 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岩渕 三哉: "リンパ球浸潤性胃癌(EBVirus関連胃癌)の病理学的特徴" 新潟大学医短紀要. 6. 117-122 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 渡辺 英伸: "潰瘍性大腸炎:病理診断" 胃と腸. 32. 309-316 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takahashi M: "Single institute analysis of 313 patients with acute lenkemia" Bull Coll Biomed Technol Niigata Univ.6. 31-38 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松田 圭二: "大きさと深達度からみた未分化型小胃癌の発育・進展" 胃と腸. 31. 1445-1455 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松田 圭二: "病理組織学からみた大腸腫瘍の自然史" 胃と腸. 31. 1633-1647 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岩渕 三哉: "日本の胃癌" 金原出版, 914 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岩渕 三哉: "消化器病[胃・腸・食道]-分子メカニズムから病態・診断・治療まで" 羊土社, 213 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岩渕 三哉: "病理学キーワード'97" 文光堂, 434 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nishikura K: "Progress in Gastric Cancer Research 1997" Mondvzzi Editore, 400 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Iwafuchi M: "Histological and hormonal characteristics of carcinoid tumor and endocrine cell carcinoma of the digestive tract" Gastroenterology. 22 (4). 358-365 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwafuchi M: "Synchronous multiple early gastric cancer ; study of surgically reseced stomach" Jpn J Clin Med. 54 (5). 1217-1223 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwafuchi M: "Carcinoid tumor of the digestive tract ; recent concepts" Surgery. 58 (11). 1305-1312 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwafuchi M: "Morphology as medical technology" Niigata University News. 606. 1 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Watanabe H: "The pathological sequence in the development of gastric cancer : II" Scand J Gastroenterol. 31 (Suppl 214). 36-39 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Watanabe H: "Histological diagnosis of esophageal dysplasia" Stomach and Intestine. 31 (6). 705-711 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Watanabe H: "Helicobacter pylori and malignant lymphoma of the stomach" Stomach and Intestine. 31 (8). 943-944 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yagi K: "A minute rectal carcinoma with massive submucosal invasion and lymph-node metastasis" Endoscopy. 28. 161 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakagawa S: "Archival analysis of p53 protein overexpression and genetic mutation in espohageal squamous call carcinoma" Acta Medica et Biologica. 44 (2). 63-69 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kudo S: "Diagnosis of colorectal tumorous lesions by magniflying endoscopy" Gastrointestinal Endoscopy. 44 (1). 8-14 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Serra I: "Gallbladder carcinoma : case control study in chile" Chilena cirugia. 48 (2). 139-147 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nishimaki T: "Early esophageal adenocarcinoma arising in a short segment of Barrett's mucosa after total gastretomy" Am J Gastrol. 91 (9). 1856-1857 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kobayashi M: "Effect of K-ras mutation on morphogenesis of colorectal adenomas and early cancers" Human Pathol. 27 (10). 1042-1049 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Dixon MF: "Classification and grading of gastritis" Am J Surg Pathol. 20 (10). 1161-1181 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masuda K: "Ulcerative colitis with overexpression of p53 preceding overt histological abnormalities of the epithelium" J Gastroenterol. 31. 860-867 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mano H: "Comparison of mutagenic activity of bile between Chilean and Japanese female patients having cholelithiasis" Mutation Research. 371. 73-77 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamada N: "Report of a case of gastric leiomyoblastoma" ENDOSCOPIC FORUM for digestive disease. 12 (1). 74-78 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ho J: "Early adenosquamous cell carcinoma of the stomach" Stomach and Intestine. 31 (7). 913-918 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Narisawa R: "Morphological changes of gastric MALToma and follicular gastritis after erradication of Helicobacter pylori" Stomach and Intestine. 31 (8). 965-972 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuda K: "Carcinogenesis of ulcerative colitis : Immunohistochemical study" Igakuno Ayumi. 178 (9). 622-629 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mastuda K: "Early colorectal carcinoma and p53 abnormality" J Clin Science. 51 (8). 1408-1421 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamaguchi K: "Report of a case gastric MALT lymphoma" Stomch and Intestine. 31 (8). 1019-1025 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masuda K: "Carcinoid tumor of the appendix" Surgery. 58 (11). 1335-1341 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masuda K: "Progression of small undifferentiated type carcinoma of the stomach" Stomach and Intestine. 31 (12). 1445-1455 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masuda K: "Natural history of colorectal carcinoma : pathological study" Stomach and Intestine. 31 (13). 1633-1647 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwafuchi M: "Pathological characteristics of grastric carcinoma with lymphoid stroma (Epstein-Barrvirus-related gastric carcinoma)" Bull Coll Biomed Technol Niigata Univ.6 (1). 117-122 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Watanabe H: "Pathological diagnosis of ulcerative colitis" Stomach and Intestine. 32 (3). 309-316 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takahashi M: "Single institute analysis of 313 patients with acute leukemia" Bull Coll Biomed technol Niigata Univ. 6 (1). 31-38 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwafuchi M: Pathological characteristics of the gastric cancer : special type in "Gastric Cancer in Japan". Kanehara, 914 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwafuchi M: Carcinoid tumor of the gastrointestinal tract in "Digestive Disease (stomach, intestine and esophagus)". Yodosha, 213 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwafuchi M: Endocrine cell tumor of the gastrointestinal tract in "Key Words of Pathology '97". Bunkoudo, 434 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nishikura K: Gastric microcarcinoma. Its histopathological in "Progress in Gastric Cancer Resarch 1997". Monduzzi Editore, 400 (1997)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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