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1997 Fiscal Year Final Research Report Summary

Molecular biological study on the mechanisms underlying seizure susceptibility and seizure development

Research Project

Project/Area Number 08671084
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionShiga University of Medical Science

Principal Investigator

KATO Nobumasa  Shiga University of Medical Science, Faculty of Medicine, Professor, 医学部, 教授 (10106213)

Co-Investigator(Kenkyū-buntansha) SADAMATSU Miyuki  St.Lukes Hospital, Psychiatry, Staff, 精神科, 医員 (90252387)
ISHIDA Nobuya  Shiga University of Medical Science, Faculty of Medicine, Lecturer, 医学部, 講師 (20159742)
Project Period (FY) 1996 – 1997
Keywordsepilepsy / immediate early gene / hippocampus / inferior colliculus / glutamate receptors / neuropeptide Y
Research Abstract

The present study was conducted to investigate neural mechanisms underlying geizure susceptibility and development with use of experimental models of epilepsy. The results were as follows : 1)Audiogenic seizure-prone rats were established by means of neonatal exposure to 0.02% propylthiouracil (PTU) through mother's milk. In situ hybridization of c-fos mRNA revealed that audiogenic seizure in these PTU-treated rats initiated in the brainstem, especially in inferior colliculus and not hippocampus. It is also suggested that NMDA receptors play a primary role within inferior colliculus.2)In contrast, genetically epilepsy-prone rats such as spontaneously epileptic rats (SER) and Ihara's genetically epileptic rats (IGER), exhibit linmbic seizures, in which hippocampus is primarily involved as reported previously. In these two genetic models we found the significant elevation of neuropeptide Y (NPY) contents in the hippocampus.3)Then, we adopted a model of selective damage in the hippocampus following trimethyltin (TMT) intoxication in the rats. In these TMT-treated rats, expression of NPY mRNA was found to be elevated in the hippocampus. Furthermore, changes in endocrine and immunological parameters such as corticosterone and cytokines were found to precede those in neuropeptides in TMT-treated rats.

  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] KATO, Nobumasa: "Expression of c-fos mRNA after andiogenic seizure in adult rats with neonatal by pothyooidism" Molecular Brain Research. 38. 85-90 (1996)

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      「研究成果報告書概要(和文)」より
  • [Publications] TAKAZAWA, Akira: "Potent and longlasting anti convnlsant effects of l-maphtylacetyl spermine,an analogue of Joyo spider toxin,against amygdaloid-" Brain Research. 706. 173-176 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] IKEDA, Masayuki: "Niric oxide Synthase-containing neurous in the hippocampus are preserved in trimethyltin intoxication" Brain Research. 712. 168-170 (1996)

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      「研究成果報告書概要(和文)」より
  • [Publications] NAGAKI, Shigeru: "The role of vasopressin,somutostatin and GABA in febrile convulsion in rat pups." Life Sciences. 58. 2233-2242 (1996)

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      「研究成果報告書概要(和文)」より
  • [Publications] ISHIDA, Nobuya: "Trimethyltin syndrome as a hippocampal degeneration model : temporal changes and neurochemical features of seizure-" Neuroscience. 81. 1183-1191 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] TAKAHASHI, Yoshinari: "Change of immunoveactive neuropeptide Y,Somatostatin,and corticolropin releasing factor(CRF)in the brain of a novel epileptic-" Brain Research. 776. 255-260 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] KATO, Nobumasa: "The Hippocampus : Functions and Clinical Relevance" Elsevier Science BV,Amsterdam, 494 (1996)

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      「研究成果報告書概要(和文)」より
  • [Publications] Kato N,Ishida N,Kanai H,Watanabe Y,Kuroda Y,and McEwen BS.: "Expression of c-fos mRNA after audiogenic seizure in adult rats with neonatal hypothyroidism. Molecul." Brain Research. 38. 85-90 (1996)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Takazawa A,Yamazaki O,Kanai H,Ishida N,Katou N,and Yamauchi T.: "Potent and long-lasting anti-convulsant effects of 1-naphty lacetyl spermine, an analigue of Joro spider toxin, against amygdaloid kindied seizures in rats." Brain Research. 706. 173-176 (1996)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Ikeda M,Kanai H,Akaike M,Tsutsumi S,Sadamatsu M,Masui A,and Kato N.: "Nitric oxide synthase-containing neurons in the hippocampus are preserved in trimethyltin intoxication." Brain Research. 712. 168-170 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagaki S,Nagaki S,Minatogawa Y,Sadamatsu M,Kato N,Osawa M,and Fukuyama Y.: "The role of vasopressin, somatostatin and GABA in febrile convulsion in rat pups." Life Sciences. 58. 2233-2242 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ishida N,Akaike M,Tsutsumi S,Kanai H,Masui A,Sadamatsu M,Kuroda Y,Watanabe Y,McEwen BS and Kato N.: "Trimethyltin syndrome as a hippocampal degeneration model : temporal changes and neurochemical features of seizure susceptibility and learning impairment." Neuroscience. 81. 1183-1191 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takahashi Y,Sadamatsu M,Kanai H,Masui A,Amano S,Ihara N and Kato N.: "Changes of immunoreactive neuropeptide Y,somatostatin, and corticotropin-releasing factor (CRF) in the brain of a novel epileptic mutant rat, Ihara's genetically epileptic rat (IGER)." Brain Research.776. 255-260 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Imai H,Kabuto M,Takita M and Kato N: "Interleukin-1 receptor antagonist inhibits transient increase of plasma corticosterone in the initial phase of trimethyltin-induced hippocampal necrosis." Neuro Toxicology. 19. 163-166 (1998)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Tsunashima K,Sadamatsu M,Takahashi Y,Kato N and Sperk G.: "Trimethyltin-induced changes in neuropeptide expression in the hippocampus." Synapse. (in press).

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      「研究成果報告書概要(欧文)」より
  • [Publications] Tsutsumi S,Akaike M,Ohno H and Kato N.: "Learning/memory impairments in rat offspring prenatally exposed to phenytoin." Neurotoxicol.Teratol. (in press).

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      「研究成果報告書概要(欧文)」より
  • [Publications] Sadamatsu M,Tsunashima K,Schwarzer C,Takahashi Y,Kato N,and Sperk G.: "Trimethyltin-induced expression of neuropetide Y-Y2 receptors in rat dentate gyrus." Neurotoxicol.Teratol.(in press).

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      「研究成果報告書概要(欧文)」より
  • [Publications] Kato N,(Ed.): The Hippocampus, Functions and Clinical Relevance.Elsevier Science BV,Amsterdam, 494 (1996)

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      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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