1998 Fiscal Year Final Research Report Summary
Analysis of liver metastasis mechanism by an antibody to TF antigen
| Project/Area Number |
08671495
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kinki University School of Medicine |
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Principal Investigator |
YASUTOMI Masayuki Kinki University School of Medicine, 1st Dept of Surgery, Professor, 医学部, 教授 (60028438)
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| Co-Investigator(Kenkyū-buntansha) |
SHIGEOKA Hironori Kinki University School of Medicine, 1st Dept of Surgery, senior stuff, 医学部・附属病院, 助手 (70247998)
TANAKA Akira Kinki University School of Medicine, 1st Dept of Surgery, assistant professor, 医学部, 講師 (60179736)
OKUNO Kiyotaka Kinki University School of Medicine, 1st Dept of Surgery, assistant professor, 医学部, 講師 (30169239)
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| Project Period (FY) |
1996 – 1998
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| Keywords | neuraminidase / Colon 26 / Thomsen-Friedenreich antigen / liver metastasis |
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| Research Abstract |
Thomsen-Friedenreich antigen (TF ; Galbeta1-3GalNAcalpha1) is expressed onmany human carcinomas. Evidence suggests that TF-carrying tumor cells specifically bind asialoglycoprotein receptors on hepatocytes with the consequence of metastasis formation in the liver. We used an animal model for examining the feasibility of preventing metastasis formation byan antibody to TF.Treatment of Colon 26 cells with neuraminidase led to the exposure of TF, and consequently to a higher frequency of liver metastases in syngeneic Balb/c mice. This could be prevented by an antibody to TF(A78-G/A7), but not by a control antibody. The results mayopen up a new strategy for the prophylaxis of metastatic spread to the liver.
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