1998 Fiscal Year Final Research Report Summary
Cadaveric Lung Transplantation
| Project/Area Number |
08671543
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Showa University |
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Principal Investigator |
KADOKURA Mitsutaka Showa University, School of Medicine, Lecturer, 歯学部, 専任講師 (60214417)
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| Co-Investigator(Kenkyū-buntansha) |
TANIO Noboru Showa University, School of Medicine, Assistant, 歯学部, 助手 (90255729)
NONAKA Makoto Showa University, School of Medicine, Assistant, 歯学部, 助手 (20266117)
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| Project Period (FY) |
1996 – 1998
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| Keywords | Lung transplantation / Cadaveric organ transplantation / Warm ischemia / Ischemia reperfusion injury / Surfactant / Low flow reperfusion / Rabbit / Rat |
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| Research Abstract |
The most serious obstacle to more widespread use of lung transplantation is the limited size of the pulmonary donor pool. Despite the realization that lung transplantation from a non-heart-beating cadaveric donors clinically feasible, the procedure has not received wide acceptance. We studied the effects of flush height, magnesium, reperfusion flow rate, initial low flow reperfusion, surfactant, low Ht, high pulmonary venous pressure, NO, and pulmonary venous heparin flush. The low flush height and low reperfusion flow rate were effective.. Though magnesium or surfactant administration was lowered the lung edema. The initial low flow reperfusion and pulmonary venous flush decreased the graft failure. These methods improved the cadaveric lung function.
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