1997 Fiscal Year Final Research Report Summary
HPV,host defense, and enviromental factors in histogenesis of cervical cancer
| Project/Area Number |
08671860
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tohoku University |
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Principal Investigator |
KANNO Ryo Tohoku Univ.Ob/Gyn.Lecturer, 医学部附属病院, 講師 (70271905)
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| Co-Investigator(Kenkyū-buntansha) |
TAKANO Tadao Tohoku Univ.Ob/Gyn, Research Associate, 医学部附属病院, 助手 (40282058)
SATO Shinji Tohoku Univ.Ob/Gyn.Lecturer, 医学部, 講師 (10142960)
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| Project Period (FY) |
1996 – 1997
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| Keywords | cervical cancer / dysplasia / HPV (human papilloma virus) / p53 / apoptosis / bcl 2 / retinoid |
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| Research Abstract |
Alterations of the p53 gene are common in human malignancies. HPV infection contributes to carcinogenesis in cervical carcinoma. Inaddition, the abnormal expression of the bcl-2 protein inhibits apoptosis in some carcinomas. We investigated the expression of the p53 protein, p53 mutations, the presence of HPV DNA,and the expression of the bcl-2 protein in cervical squamous cell carcinomas. Some cervical carcinomas which have wild-type p53 protein may have developed from the inhibition of apoptosis secondary to bcl-2 protein overexpression. The present results suggest that oervical carcinoma differs from other common human malignancies in the manner in which p53 gene alterations are involved in carcinogenesis.
To evaluate the clinical significance of human papillomavirus (HPV) type, the grade of cervical intraepithelial neoplasia (CIN), and age on the progression of CIN.Clinical follow-up data, histopathologic diagnosis, polymerase chain reaction (PCR) detemined HPV DNA typing were analyzed. HPV positivity (P=.0466), especially HPV16 positivity (P=.0104), was significantly more frequent than HPV negativity in the progression group. Multiple logistic regression analysis revealed that HPV (odds ratio 2.23, P=.0103) and the grade of the lesion (odds ratio 3.30, P=.0002) in the initial biopsy strongly and independently correlated with progression of CIN.HPV status and histologic grade are independent predictive risk factors for progression and may be useful in the management of CIN.
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