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1998 Fiscal Year Final Research Report Summary

Expression of fluid regulation peptides in the inner ear.

Research Project

Project/Area Number 08671961
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionShiga Universityof Medical Science

Principal Investigator

KITANO Hiroya  Shiga University of Medical Science, Department of Otolaryngology, Asistant Professor., 医学部, 講師 (20153108)

Co-Investigator(Kenkyū-buntansha) TOOYAMA Ikuo  Shiga University of Medical Science, Department of Molecular Neurobiology Reseac, 分子神経生物学研究センター, 助教授 (20207533)
KIMURA Hiroshi  Shiga University of Medical Science, Department of Molecular Neurobiology Reseac, 分子神経生物学研究センター, 教授 (40079736)
YAZAWA Yoshiro  Shiga University of Medical Science, Department of Otolaryngology, Associate Pro, 医学部, 助教授 (60127040)
Project Period (FY) 1996 – 1998
Keywordsmolecular biology / inner ear / Meniere's disease / endolymphatic hydrops / inner ear fluid regultion / vasopressin / CNP / VIP
Research Abstract

The anti-diuretic hormone, vasopressin, has been shown to be important in regulating inner ear fluid. The diuretic hormone, CNP, and its receptor, ANP-B receptor, may also function in the regulation of inner ear fluid. To determine whether vasopressin directly affects the fluid level, we infused this hormone to rat and assay of V2-AVP receptor mRNA by semiquantitative RT-PCR demonstrated a significantly lower level of this transcript in vasopressin-infused animals than in saline-infused animals. The levels of CNP and ANP-B receptors mRNA, however, were the same in both groups of rats. Results suggest that high plasma levels of vasopressin may be a principal causal factor of endolymphatic hydrops in Meniere's disease, perhaps by down-regulating the number of vasopressin receptors.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] 水野 博也: "内耳代謝作動ペプチドについて" Otol.Japan. 52. 52-57 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 遠山育夫: "ナトリウム利尿ペプチド受容体" 生命の化学. 49. 401-402 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 水野博也: "バソプレッシンによる内耳水代謝の制御" 頭頚部自律神経. 印刷中 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kitano. H.: "Presence of mRNA for VIP and its receptor in the rat inner ear" Hear. Res.121. 109-111 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kitanishi. T.: "Immurohistochemical detection of VIP and VIP receptor in the rat inner ear" Acta Otolaryngol. (印刷中). (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kitano, H.: "Regulation of inner ear fluid in the rat by vasopressin" Neuro Report. (印刷中). (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzaki M,Kitano H,Kitanishi T,Yazawa Y,Kitajima K,Takeda T,Kimura H,Tooyama I.: "Detection of C-type natriuretic peptide (CNP) and atrial natriuretic peptide (ANP-B) receptor mRNAs in rat inner ear." NeuroReport. 18. 439-443 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kitano H,Takeda T,Suzuki M,Kitanishi T,Yazawa Y,Kitajima K,Kimura H,Tooyama I.: "Vasopressin and oxytocin receptor mRNA are expressed in the rat inner ear." NeuroReport. 18. 2289-2292 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki M, Kitano H,Kitanishi T,Yazawa T,Kitajima K,Takeda T,Kimura H,Tooyama I.: "RT-PCR analysis of mRNA expression of natriuretic peptide family and their receptors in rat inner ear." Brain Res Mol Brain Res. 55. 165-168

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kitano H,Takeda T,Suzuki M,Kitanishi T,Yazawa Y,Kitajima K,Kimura H,Tooyama I.: "Presence of mRNA for vasoactive intesinal polypeptide (VIP) and its receptor in the rat inner ear." Hear Res.121 (1-2). 109-111 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kitanishi T,Suzuki M,_ Kitano H,Yazawa Y,Kitajima K.: "Immunohistochemical detection of vasoactive intestinal polypeptide (VIP) and the VIP receptor in the rat inner ear." Acta Otolaryngol (supple). (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kitano H,Suzuki M,Kitanishi T,Yazawa Y,Kitajima K,Takeda T,Kimura H,Tooyama I.: "Regulation of inner ear fluid in the rat by vasopressin." NeuroReport. (in Press).

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-12-08  

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