1998 Fiscal Year Final Research Report Summary
Expression of fluid regulation peptides in the inner ear.
| Project/Area Number |
08671961
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Shiga Universityof Medical Science |
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Principal Investigator |
KITANO Hiroya Shiga University of Medical Science, Department of Otolaryngology, Asistant Professor., 医学部, 講師 (20153108)
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| Co-Investigator(Kenkyū-buntansha) |
TOOYAMA Ikuo Shiga University of Medical Science, Department of Molecular Neurobiology Reseac, 分子神経生物学研究センター, 助教授 (20207533)
KIMURA Hiroshi Shiga University of Medical Science, Department of Molecular Neurobiology Reseac, 分子神経生物学研究センター, 教授 (40079736)
YAZAWA Yoshiro Shiga University of Medical Science, Department of Otolaryngology, Associate Pro, 医学部, 助教授 (60127040)
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| Project Period (FY) |
1996 – 1998
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| Keywords | molecular biology / inner ear / Meniere's disease / endolymphatic hydrops / inner ear fluid regultion / vasopressin / CNP / VIP |
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| Research Abstract |
The anti-diuretic hormone, vasopressin, has been shown to be important in regulating inner ear fluid. The diuretic hormone, CNP, and its receptor, ANP-B receptor, may also function in the regulation of inner ear fluid. To determine whether vasopressin directly affects the fluid level, we infused this hormone to rat and assay of V2-AVP receptor mRNA by semiquantitative RT-PCR demonstrated a significantly lower level of this transcript in vasopressin-infused animals than in saline-infused animals. The levels of CNP and ANP-B receptors mRNA, however, were the same in both groups of rats. Results suggest that high plasma levels of vasopressin may be a principal causal factor of endolymphatic hydrops in Meniere's disease, perhaps by down-regulating the number of vasopressin receptors.
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