1997 Fiscal Year Final Research Report Summary
NEURONAL CIRCUIT FORMATION IN THE GENETICAL AND EXPERIMENTAL BRAIN MALFORMATION ANIMAL.
Project/Area Number |
08680824
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Nerve anatomy/Neuropathology
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Research Institution | DOKKYO UNIVERSITY SCHOOL OF MEDICINE |
Principal Investigator |
UEDA Shuichi DOKKYO UNIVERSITY SCHOOL OF MEDICINE,PROFESSOR, 医学部, 教授 (60150570)
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Co-Investigator(Kenkyū-buntansha) |
AIKAWA Masuo DOKKYO UNIVERSITY SCHOOL OF MEDICINE,RESEARCH ASSOCIATE, 医学部, 助手 (00049256)
OKA Atsuko DOKKYO UNIVERSITY SCHOOL OF MEDICINE,ASSISTANT PROFESSOR, 医学部, 講師 (50175254)
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Project Period (FY) |
1996 – 1997
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Keywords | S-100beta / Serotonin / Mutant mouse / Glia / Immunohistochemistry / Growth factor / Raphe nucleus / Cortex |
Research Abstract |
Homozygote of a mouse strain with genetic polydactyly (Pdn) show disrupted cortical lamination and significant decrease of S-100beta immunoreactive elements in a particular area of the brain. In order to understand the abnormal cortical formation at the cellular level, migration of cortical neurons and development of glia cells were studied using bromodeoxyuridine (BrdU), S-100beta and glial fibrillary acidic protein (GFAP) immunohistochemistry. Homozygous mice (Pdn/Pdn) displayd a variable pattern of abnormalities. Irregular GFAP-positive radial glia cells and disturbance of neuronal migration were found in a circumscribed area of the caudo-dorsal cortex of newborn Pdn mouse. The number of S-100beta-positive cells was reduced in this area. The present results suggest that abnormal cortical lamination closely correlates with disturbance of neuronal migration and abnormalities of glia cells, especially a significant decrease of S-100beta immunoreactive cells.
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Research Products
(33 results)
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[Publications] Ueda, S., Matsumoto, Y., Ishizuya-Oka, A., Aikawa, M., Nishimura, A., and Kawata, M.: "Organization of regenerating serotonergic fibers in the hippocampal formation" Brain Res.Bull.39. 89-99 (1996)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Ueda, S., Aikawa, M., Kawata, M., Naruse, I., Whitaker-Azmitia, P.M., Azmitia, E.C.: "Neuro-glial neurotrophic interaction in the S-100beta retarded mutant mouse (Polydactyly Nagoya). III.Transplantation study" Brain Res.738. 15-23 (1996)
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[Publications] Yoshimoto, K., Yayama, K., Sorimachi, Y., Tani, J., Ogata, M., Nishimura, A., Yoshida, T., Ueda, S., and Komura, S.: "Possibility of 5-HT3 receptor involvement in alcohol dependence : A microdialysis study of nucleus accumbens dopamine and serotonin release in rats with chronic alcohol consumption" Alcohol.Clin.Exp.Res.20. 311A-319A (1996)
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「研究成果報告書概要(欧文)」より
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[Publications] Yoshimoto, K., Yayama, K., Sorimachi, Y., Tani, J., Uemura, K., Yoshida, T., Ogata, M., Nishimura, A., Ueda, S., Komura, S.: "Effects of ion channel blockers on rapid postmortem changes in extracellular dopamine and serotonin levels in the rat nucleus accumbens" Forensic Science International. 85. 29-39 (1997)
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「研究成果報告書概要(欧文)」より
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[Publications] Yoshimoto, K., Sorimachi, Y., Li, Y.-J., Uemura, K., Yayama, K., Tani, J., Ueda, S., and Komura, S.: "Effects of ethanol on the levels of brain 6R-L-Erythro-5,6,7,8-tetrahydrobiopterin in the inbred strains of mice, DBA/2J,C3H/HeJ and C57BL/6J with different alcohol preferences" Jpn.J.Alcohol & Drug Dependence. 32. 139-148 (1997)
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「研究成果報告書概要(欧文)」より
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[Publications] Yoshimoto, K., Yoshida, T., Takeuchi, Y., Ueda, S.: "The effects of 6R-L-Erythro-5,6,7,8-tetrahydrobiopterin on ethanol-induced sleep time and ethanol elimination in inbred strains of mice withy different alcohol preference" Neuropsychobiology. 36. 188-193 (1997)
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「研究成果報告書概要(欧文)」より
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[Publications] Ishizuya-Oka, A., Ueda, S., Damjanovski, S., Li, Q., Liang, V.C.-T., Shi, Y.-B.: "Anteroposterior gradient of epithelial transformation durign amphibian intestinal remodeling : Immunohistochemical detection of intestinal fatty acid-binding protein" Dev.Biol.192. 149-161 (1997)
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「研究成果報告書概要(欧文)」より
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[Publications] Ueda, S., Aikawa, M., Ishizuya-Oka, A., Koibuchi, N., Yamaoka, S., Yoshimoto, K.: "Age-related degeneration of the serotoninergic fibers in the zitter brain" Synapse. (in press).
Description
「研究成果報告書概要(欧文)」より