1999 Fiscal Year Final Research Report Summary

An International Study of Malignant Transformation of Oral Leukoplakia

Research Project

Project/Area Number	09045077
Research Category	Grant-in-Aid for Scientific Research (B).
Allocation Type	Single-year Grants
Section	一般
Research Field	Surgical dentistry
Research Institution	Tokyo Medical and Dental University
Principal Investigator	AMAGASA Teruo TOKYO MEDICAL AND DENTAL UNIVERSITY POSTGRADUATE SCHOOL PROFESSOR, 医歯学総合研究科, 教授 (00014332)
Co-Investigator(Kenkyū-buntansha)	IWAKI Hiroshi TOKYO MEDICAL AND DENTAL UNIVERSITY POSTGRADUATE SCHOOL LECTURER, 医歯学総合研究科, 講師 (70107308) YOSHIMASU Hidemi TOKYO MEDICAL AND DENTAL UNIVERSITY POSTGRADUATE SCHOOL ASSOCIATE PROFESSOR, 医歯学総合研究科, 助教授 (70137933) TAKAGI Minoru TOKYO MEDICAL AND DENTAL UNIVERSITY POSTGRADUATE SCHOOL PROFESSOR, 医歯学総合研究科, 教授 (30014012) FUJII Eiji KOFU MUNICIPAL HOSPITAL CHIEF, 医長 (20221541)
Project Period (FY)	1997 – 1999
Keywords	oral leukoplakia / premalignant lesion / high risk group / clinical type / epithelial dysplasia / 上皮性異形成
Research Abstract	Oral leukoplakia is considered to be a premalignant lesion and could develop carcinoma with a frequency ranging from 5 to 10 percent. The purpose of this study is to clarify risk factors for malignant transformation by comparing Japanese cases of leukoplakia with those in Denmark, applying a common oral leukoplakia protocol, which was made by collaboration between Copenhagen University and Tokyo Medical and Dental University in 1997. In the protocol, items such as age, sex, chief complaint, duration, site, clinical type, tobacco, alcohol, epithelial dysplasia and candidosis were examined. We investigated the protocols of two countries. For example, the preferential sites for leukoplakia of our cases are gingiva tongue, and buccal mucosa, however, those in Denmark are buccal mucosa, floor of the mouth and gingiva. Such differences may be due to customs or environmental factors. Examining such differences and Following cases by the protocol will contribute to clarification of high risk group of leukoplakia.