1999 Fiscal Year Annual Research Report

転写調節機構から挑む高次生命現象の解析研究の推進

Research Project

Project/Area Number	09277101
Research Institution	Tohoku University
Principal Investigator	藤井義明東北大学, 大学院・理学研究科, 教授 (00098146)
Co-Investigator(Kenkyū-buntansha)	加藤茂明東京大学, 分子細胞生物学研究所, 教授 (60204468) 岩淵雅樹岡山県生物科学総合研究所, 所長 (30000839) 石井俊輔理化学研究所, ライフサイエンス筑波研究センター, 主任研究員 (00124785) 山本雅之筑波大学, 基礎医学系, 教授 (50166823) 半田宏東京工業大学, フロンティア創造共同研究センター, 教授 (80107432)
Keywords	総括班会議 / ニュースレター / コンファランス / 転写調節 / ワークショップ / 転写調節から疾患 / 遺伝学的アプローチ / 研究報告書
Research Abstract	5月10日(月)に総括班会議(幹事会)を東京で開催し、本年度の活動方針を決定した。決定事項は次の通りである。ニュースレターを年3回(8月、12月、3月)、班員名簿(6月)を発行し、計画研究を公募研究の研究成果を年度末(3月)に発行する。コンファランス、公開シンポジウム及び若手研究者を中心とするワークショップを各々年1回開催する。これらの活動方針は順調に行われ、名簿は6月、ニュースレターは8月、12月に発行され、3月の発行も予定通りに進行している。公開シンポジウムは「細胞内シグナル伝達と転写調整」というタイトルのもとに6月1日(火)東大本郷キャンパス山上会議所で開催された。北海道や九州からの参加もあり、参加者数は200名に近く、活発な討論に終始した。コンファランスは9月16日(木)〜18日(土)京都平安会館で行われた。参加者は研究班員、班友及び同伴者を含め、合計125名であった。スピーカーは計画研究、公募研究班員54名、班友4名で合計58名であった。活発な討論があり、構造研究者と機能の研究者の共同研究の成果の発表もあって、稔の多いコンファランスであった。若手研究者の育成を目的に開かれる若手冬のワークショップは今年度も平成12年1月11日(火)〜13日(木)まで妙高高原で開かれ、約50名の参加者があった。会は"転写調節から疾患へのアプローチ"、"生命現象への遺伝学的アプローチ"、"様々な生物を用いた転写研究へのアプローチ"の3セッションと2題の特別講演で構成され合計19題の話題提供があった。総括班は会場費と話題提供者の宿泊費及び交通費の一部を支援した。会は午後スキーを楽しみながら、午前と夜はインフォーマルな雰囲気で大変活発な討論がなされた。今年度の研究報告書は3月中に発行されるために準備は順調に進められている。

Research Products
(23 results)

All Other

All Publications (23 results)

[Publications] J.Mimura, et.al: "Identification of a novel mechanism of regulation of Ah (dioxin) receptor function"Genes Dev.. 13. 20-25 (1999)
[Publications] M.Ema, et.al: "Mild impairment of learning and memory in mice overexpressing mSim2 gene located in chromosome 16, an animal model of a Down syndrome"Hum.Molec. Genet.. 18. 1905-1914 (1999)
[Publications] R.J.Denver, et.al: "Basic Transcription Element Binding Protein (BTEB) is a Thyroid Homone-Regulated Gene in the Developing Ventral Nervous System : Evidence for Role in Neurite Outgrowth"J. Biol. Chem.. 274. 23128-23134 (1999)
[Publications] K.Taoka, et.al: "Identification of Threen kiuds of Mutually related composite Elements Conferring Spkase-specific transcriptional activation"Plant J.. 18. 611-623 (1999)
[Publications] Y.Kobayashi, et.al: "A pair of related genes with antagonistic roles in mediating flowering signals"Science. 3. 286-1960 (1999)
[Publications] K.Sekine, et.al: "FGF10 is essential for the limb and lung formation"Nature Genetics. 21. 138-141 (1999)
[Publications] H.Endoh, at.al: "Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor a"Mol. Cell. Biol.. 19. 5363-5372 (1999)
[Publications] J.Yanagisawa, et.al: "Convergence of TGFb and vitaminD signaling pathways on SMAD proteins acting as common transcriptional co-activators"Science. 283. 1317-1321 (1999)
[Publications] Y.Yamaguchi, et.at: "NELF, a multiple complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation"Cell. 274. 8085-8092 (1999)
[Publications] Y.Yamaguchi, et.al: "Structure and function of the human transcription elongation factor DSIF"J. Biol. Chem.. 274. 8085-8092 (1999)
[Publications] J.A. Kim, et.al: "Tat-SF1 proteing associates with RAP30 of TFIIF and hSPT protein"Mol. Cell. Biol.. 19. 5960-5968 (1999)
[Publications] Y.Saijho, et.al: "Distinct transcriptional regulatory mechanisms underline left-right asymmetric expression of lefty-1 and lefty-2"Genes & Dev.. 13. 259-269 (1999)
[Publications] H.Adachi, et.al: "Determination of left-right asymmetric expression of nodal by a left side-specific enhancer with sequence similarity to a lefty-2 enhancer"Genes & Dev.. 13. 1589-1600 (1999)
[Publications] J.Nishino, et.al: "GFRa3, a putative coreceptor of Artemin, is required for the migration and survival of the superior surperior cervical ganglion"Neuron. 23. 725-736 (1999)
[Publications] K.Itoh, et.al: "Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the N-terminal Neh2 domain"Genes & Dev.. 13. 76-86 (1999)
[Publications] N.Minegishi, et.al: "The mouse GATA-2 gene is expressed in the aorta-gonads-mesonephros region"Blood. 93. 4196-4207 (1999)
[Publications] O.Nakajima, et.al: "Heme deficiency in erythroid lineage causes differentiation arrest and cytoplasmic iron overload"EMBO J.. 18. 6282-6289 (1999)
[Publications] S.Kameya, et.al: "α1-Syntrophin gene disruption results in the absence of neuronal-type nitoric-oxide synthase at the sarcolemma but dose not induce muscle degeneration"J. Biol. Chem.. 274. 2193-2200 (1999)
[Publications] M.Hoshino, et.al: "Identification of the stef gene that encodes a novel guanine nucleotide exchange factor specific for Rac I"J. Biol. Chem.. 274. 17837-17844 (1999)
[Publications] S.Murata, et.al: "Growth retardation in mice lacking the proteasome activator PA28γ"J. Biol. Chem.. 274. 38211-38215 (1999)
[Publications] T.Nomura, et.al: "Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad nd thyroid hormone receptor"Genes & Development. 13. 412-423 (1999)
[Publications] P.Dai, et.al: "Sonic hedgehog-induced activation of the Glil promoter is mediated by GLI3"J. Biol. Chem.. 274. 8143-8152 (1999)
[Publications] Y.Sano, et.al: "ATF-2 is a common nuclear target of Smad and TAK1 pathways in TGF-signaling"J. Biol. Chem.. 274. 8949-8957 (1999)

1999 Fiscal Year Annual Research Report

転写調節機構から挑む高次生命現象の解析研究の推進

Principal Investigator

藤井 義明 東北大学, 大学院・理学研究科, 教授 (00098146)

Research Products

[Publications] J.Mimura, et.al: "Identification of a novel mechanism of regulation of Ah (dioxin) receptor function"Genes Dev.. 13. 20-25 (1999)

[Publications] M.Ema, et.al: "Mild impairment of learning and memory in mice overexpressing mSim2 gene located in chromosome 16, an animal model of a Down syndrome"Hum.Molec. Genet.. 18. 1905-1914 (1999)

[Publications] R.J.Denver, et.al: "Basic Transcription Element Binding Protein (BTEB) is a Thyroid Homone-Regulated Gene in the Developing Ventral Nervous System : Evidence for Role in Neurite Outgrowth"J. Biol. Chem.. 274. 23128-23134 (1999)

[Publications] K.Taoka, et.al: "Identification of Threen kiuds of Mutually related composite Elements Conferring Spkase-specific transcriptional activation"Plant J.. 18. 611-623 (1999)

[Publications] Y.Kobayashi, et.al: "A pair of related genes with antagonistic roles in mediating flowering signals"Science. 3. 286-1960 (1999)

[Publications] K.Sekine, et.al: "FGF10 is essential for the limb and lung formation"Nature Genetics. 21. 138-141 (1999)

[Publications] H.Endoh, at.al: "Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor a"Mol. Cell. Biol.. 19. 5363-5372 (1999)

[Publications] J.Yanagisawa, et.al: "Convergence of TGFb and vitaminD signaling pathways on SMAD proteins acting as common transcriptional co-activators"Science. 283. 1317-1321 (1999)

[Publications] Y.Yamaguchi, et.at: "NELF, a multiple complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation"Cell. 274. 8085-8092 (1999)

[Publications] Y.Yamaguchi, et.al: "Structure and function of the human transcription elongation factor DSIF"J. Biol. Chem.. 274. 8085-8092 (1999)

[Publications] J.A. Kim, et.al: "Tat-SF1 proteing associates with RAP30 of TFIIF and hSPT protein"Mol. Cell. Biol.. 19. 5960-5968 (1999)

[Publications] Y.Saijho, et.al: "Distinct transcriptional regulatory mechanisms underline left-right asymmetric expression of lefty-1 and lefty-2"Genes & Dev.. 13. 259-269 (1999)

[Publications] H.Adachi, et.al: "Determination of left-right asymmetric expression of nodal by a left side-specific enhancer with sequence similarity to a lefty-2 enhancer"Genes & Dev.. 13. 1589-1600 (1999)

[Publications] J.Nishino, et.al: "GFRa3, a putative coreceptor of Artemin, is required for the migration and survival of the superior surperior cervical ganglion"Neuron. 23. 725-736 (1999)

[Publications] K.Itoh, et.al: "Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the N-terminal Neh2 domain"Genes & Dev.. 13. 76-86 (1999)

[Publications] N.Minegishi, et.al: "The mouse GATA-2 gene is expressed in the aorta-gonads-mesonephros region"Blood. 93. 4196-4207 (1999)

[Publications] O.Nakajima, et.al: "Heme deficiency in erythroid lineage causes differentiation arrest and cytoplasmic iron overload"EMBO J.. 18. 6282-6289 (1999)

[Publications] S.Kameya, et.al: "α1-Syntrophin gene disruption results in the absence of neuronal-type nitoric-oxide synthase at the sarcolemma but dose not induce muscle degeneration"J. Biol. Chem.. 274. 2193-2200 (1999)

[Publications] M.Hoshino, et.al: "Identification of the stef gene that encodes a novel guanine nucleotide exchange factor specific for Rac I"J. Biol. Chem.. 274. 17837-17844 (1999)

[Publications] S.Murata, et.al: "Growth retardation in mice lacking the proteasome activator PA28γ"J. Biol. Chem.. 274. 38211-38215 (1999)

[Publications] T.Nomura, et.al: "Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad nd thyroid hormone receptor"Genes & Development. 13. 412-423 (1999)

[Publications] P.Dai, et.al: "Sonic hedgehog-induced activation of the Glil promoter is mediated by GLI3"J. Biol. Chem.. 274. 8143-8152 (1999)

[Publications] Y.Sano, et.al: "ATF-2 is a common nuclear target of Smad and TAK1 pathways in TGF-signaling"J. Biol. Chem.. 274. 8949-8957 (1999)

藤井義明東北大学, 大学院・理学研究科, 教授 (00098146)