2001 Fiscal Year Annual Research Report

転写調節機構から挑む高次生命現象の解析研究の推進

Research Project

Project/Area Number	09277101
Research Institution	Tohoku University
Principal Investigator	藤井義明東北大学, 大学院・生命科学研究科, 教授 (00098146)
Co-Investigator(Kenkyū-buntansha)	半田宏東京工業大学, フロンティア創造共同研究センター, 教授 (80107432) 加藤茂明東京大学, 分子細胞生物学研究所, 教授 (60204468) 石井俊輔理化学研究所, ライフサイエンス筑波研究センター, 主任研究員 (00124785) 鍋島陽一京都大学, 大学院・医学研究科, 教授 (60108024) 山本雅之筑波大学, 基礎医学系, 教授 (50166823)
Keywords	報告書 / シンポジウム / 基本転写因子 / 転写共役因子 / 転写伸長反応 / クロマチン再構成系による転写機構 / DNA結合転写調節因子 / シグナル伝達と転写因子
Research Abstract	1997年4月〜2001年3月まで行われた特別推進研究"転写調節機構から挑む高次生命現象の解析研究の推進"の研究取りまとめの研究班は主に2つの活動を行った。一つは英文の報告書の発行と転写調節機構のシンポジウムを10月15、16日に筑波大学において開催した。英文の報告書は"Transcriptional Mechanisms Controlling Organized Functionsins Vertebrates"の題名で、本特定の分担者合計87名の研究のsummary、文献リスト、代表的論文及び文献のまとめより構成されている。論文の合計900編、論文の平均インパクト係数は8.3でCell、Nature、Scienceなども含めて、質の高い国際的専門誌に掲載されたものが多かった。シンポジウムは46名の講演者が発表し、約250名の参加者があった。発表者は基本転写因子、転写共役因子、転写伸長反応、クロマチン再構成系による転写機構、DNA結合転写調節因子、シグナル伝達と転写因子など転写調節に関する過去4年間のまとめと最新の成果が発表された。多くの質疑応答がなされ、活発な雰囲気の中に終始したシンポジウムであった。

Research Products

(14 results)

All Other

All Publications (14 results)

[Publications] Baba T, Mimura J, et al.: "Structure and expression of the Ah receptor repressor gene"J Biol Chem.. 276. 33101-33110 (2001)
[Publications] Hosoya T, Oda Y, et al.: "Defective development of secretory neurones in the hypothalamus of Arnt2-knockout mice. Genes Cells"Genes Cells.. 6. 361-374 (2001)
[Publications] Kokuro K, Kaul SC, et al.: "The Ski protein family is required for MeCP2-mediated transcriptional repression"J Biol Chem.. 276. 34115-34121 (2001)
[Publications] Khan MM, Nomura T, et al.: "Role of PML and PML-RARalpha in Mad-mediated transcriptional repression"Mol.Cell.. 7. 1233-1243 (2001)
[Publications] Yahata T, Shao W, et al.: "Selective coactivatlon of estrogen-dependent transcription by CITED1 CBP/p300-binding protein"Genes Dev.. 15. 2598-2612 (2001)
[Publications] Watanabe M, Yanagisawa J, et al.: "A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA"EMBO J.. 20. 1341-1352 (2001)
[Publications] Mizuguchi R, Sugimori M, et al.: "Combinatorial roles of olig2 and neurogenin2 in the coordinated induction of pan-neuronal and subtype-specific properties of motoneurons"Neuron. 31. 757-771 (2001)
[Publications] Uchida A, Komiya Y, et al.: "Neurofilarnents of Klotho, the mutant mouse prematurely displaying symptoms resembling human aging"J Neurosci Res.. 64. 364-370 (2001)
[Publications] Meno C, Takeuchi J, et al.: "Diffusion of nodal signaling activity in the absence of the feedback inhibitor Lefty2"Dev Cell.. 1. 127-138 (2001)
[Publications] Yamamoto M, Meno C, et al.: "The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse"Genes Dev.. 15. 1242-1256 (2001)
[Publications] Kataoka K, Handa H, et al.: "Induction of cellular antioxidative stress genes through heterodimeric transcription factor Nrf2/small Maf by antirheumatic gold(I) compounds"J Biol Chem.. 276. 34074-34081 (2001)
[Publications] Yamaguchi Y, Filipovska J, et al.: "Stimulation of RNA polymerase II elongation by hepatitis delta antigen"Science. 293. 124-127 (2001)
[Publications] Simizu R, Takahashi S, et al.: "In vivo requirements for GATA-1 functional domains during primitive and definitive erythropolesis"EMBO J.. 20. 5250-5260 (2001)
[Publications] Kobayashi M, Nishikawa K, et al.: "Hematopoietic regulatory domain of gatal gene is positively regulated by CATA1 protein in zebrafish embryos"Development. 128. 2341-2350 (2001)

2001 Fiscal Year Annual Research Report

転写調節機構から挑む高次生命現象の解析研究の推進

Principal Investigator

藤井 義明 東北大学, 大学院・生命科学研究科, 教授 (00098146)

Research Products

[Publications] Baba T, Mimura J, et al.: "Structure and expression of the Ah receptor repressor gene"J Biol Chem.. 276. 33101-33110 (2001)

[Publications] Hosoya T, Oda Y, et al.: "Defective development of secretory neurones in the hypothalamus of Arnt2-knockout mice. Genes Cells"Genes Cells.. 6. 361-374 (2001)

[Publications] Kokuro K, Kaul SC, et al.: "The Ski protein family is required for MeCP2-mediated transcriptional repression"J Biol Chem.. 276. 34115-34121 (2001)

[Publications] Khan MM, Nomura T, et al.: "Role of PML and PML-RARalpha in Mad-mediated transcriptional repression"Mol.Cell.. 7. 1233-1243 (2001)

[Publications] Yahata T, Shao W, et al.: "Selective coactivatlon of estrogen-dependent transcription by CITED1 CBP/p300-binding protein"Genes Dev.. 15. 2598-2612 (2001)

[Publications] Watanabe M, Yanagisawa J, et al.: "A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA"EMBO J.. 20. 1341-1352 (2001)

[Publications] Mizuguchi R, Sugimori M, et al.: "Combinatorial roles of olig2 and neurogenin2 in the coordinated induction of pan-neuronal and subtype-specific properties of motoneurons"Neuron. 31. 757-771 (2001)

[Publications] Uchida A, Komiya Y, et al.: "Neurofilarnents of Klotho, the mutant mouse prematurely displaying symptoms resembling human aging"J Neurosci Res.. 64. 364-370 (2001)

[Publications] Meno C, Takeuchi J, et al.: "Diffusion of nodal signaling activity in the absence of the feedback inhibitor Lefty2"Dev Cell.. 1. 127-138 (2001)

[Publications] Yamamoto M, Meno C, et al.: "The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse"Genes Dev.. 15. 1242-1256 (2001)

[Publications] Kataoka K, Handa H, et al.: "Induction of cellular antioxidative stress genes through heterodimeric transcription factor Nrf2/small Maf by antirheumatic gold(I) compounds"J Biol Chem.. 276. 34074-34081 (2001)

[Publications] Yamaguchi Y, Filipovska J, et al.: "Stimulation of RNA polymerase II elongation by hepatitis delta antigen"Science. 293. 124-127 (2001)

[Publications] Simizu R, Takahashi S, et al.: "In vivo requirements for GATA-1 functional domains during primitive and definitive erythropolesis"EMBO J.. 20. 5250-5260 (2001)

[Publications] Kobayashi M, Nishikawa K, et al.: "Hematopoietic regulatory domain of gatal gene is positively regulated by CATA1 protein in zebrafish embryos"Development. 128. 2341-2350 (2001)

藤井義明東北大学, 大学院・生命科学研究科, 教授 (00098146)