| Co-Investigator(Kenkyū-buntansha) |
HANDA Hiroshi Frontier Collaborative Research Center, Tokyo Institute of Technology, Professor, フロンティア創造共同研究所, 教授 (80107432)
KATO Shigeaki Institute of Molecular and Cellular Biosciences, The University of Tokyo, Professor, 分子細胞生物学研究所, 教授 (60204468)
ISHII Syunsuke Laboratory of Molecular Genetics, Researcher, ライフサイエンス筑波研究センター, 主任研究員 (00124785)
NABESHIMA Youichi Department of Pathology&Tumor Biology, Graduate School of Medicine, Kyoto University, Professor, 大学院・医学研究科, 教授 (60108024)
YAMAMOTO Masayuki Institute of Basic Medical Sciences/Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Professor, 基礎医学系, 教授 (50166823)
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| Research Abstract |
For 4 years of investigation term supported under the research project of Scientific Research in Priority Areas, approximately 900papers have been published in the international journals with an aerage citation index of 8.3 per paper. Both quantity and quality of the published papers of this research project have clearly made substantial contribution to the field of transcriptional regulation. The research groups consisted of two subgroups which pursued pursued the two main projects : 1)Mechanism of interactions between transcription factors and molecular mechanisms mechanisms of expression of thir transcriptional actiuity, 2)Search for target genes targeting technology. The steering steering commitee of this project promsted the communication and discussion between two subgroups to occelerate the progress in research work and hold symposia on transcriptional reeyulation to publisigze the results obtained by the research group. The results are enormous ranging from novel transcription factors, coactiwators, corepressors and and foctors involved in transcription elongaion and initiation Target genes and functions of the transcription factors have been elucidated by gene targeting technology. Undifferentiated states of stem cells have been clarified to be maintained by teh expression of transcription repressons.
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