2001 Fiscal Year Final Research Report Summary
Structure-Based Understanding of Diversity and Similarity of Cellular Motors
| Project/Area Number |
09279101
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas (A)
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| Allocation Type | Single-year Grants |
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SUTOH Kazuo Graduate Scool of Arts and Sciences, The University of Tokyo, Professor, 大学院・総合文化研究科, 教授 (20111453)
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| Co-Investigator(Kenkyū-buntansha) |
TOYOSHIMA Yoko Graduate School of Arts and Sciences, The University of Tokyo, Associate Professor, 大学院・総合文化研究科, 助教授 (40158043)
KAMIYA Ritsu Graduate Scool of Science, Department of Biology, The University of Tokyo, Professor, 大学院・理学系研究科, 教授 (10124314)
KAMIMURA Shinji Graduate School of Arts and Sciences, The University of Tokyo, Associate Professor, 大学院・総合文化研究科, 助教授 (90177585)
OSAWA Fumio Aichi Institute of Technology, faculity of Engineering, Professor, 工学部, 教授 (50022497)
EBASHI Setsuro Medicine, The University of Tokyo, Professor Emeritus, 医学部, 名誉教授 (10009863)
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| Project Period (FY) |
1997 – 2000
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| Keywords | Molecular motors / Myosin / Nucleic acid motors / Kinesin / Dynein |
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| Research Abstract |
This research was aimed at elucidating the characteristic functional properties of Motor proteins are involved in a variety of cellular processes such as cell locomotion, cell division, phagocytosis, endocytosis and vesicle transport. These motor proteins consist of three super-families ; myosin, kinesin and dynein. Although all of these proteins have the common function to change the chemical energy released by ATP hydrolysis to mechanical energy such as filament sliding and force, their in vitro and in vivo motor functions are surprisingly diverse. We have organized the reseairch project to understand the molecular mechanism of the diverse motor functions. To carry out the project, the following three research groups have been organized. (1) Searching for new motor proteins. (2) Dynamics of motor functions. (3) Single molecule imaging and manipulation. Besides these organized groups, individual researchers have been also recruited. To coordinate these researches, we have organized a meeting and a international conference each year. We have also devised various ways to enhance collaboration among the researchers in this project. This 4 year project has finally produced large number of important publications including many collaborative papers to which a number of members of this project have contributed.
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