TAKANI Masako Kanazawa University, Faculty of Pharmaceutical Science, Lecturer, 薬学部, 講師 (40019667)
HIROTA Shun Nagoya University, Graduate School of Science, Research Associate, 大学院・理学研究科, 助手 (90283457)
ODANI Akira Nagoya University, Graduate School of Science, Associate Professor, 大学院・理学研究科, 助教授 (60143913)
New coordination chemistry of aromatic rings in the proximity of a metal ion was pursued by the studies of the model chemical systems and metalloproteins. Various specific noncovalent interactions such as metal-aromatic, aromatic-aromatic stacking interactions have been established by structural, spectroscopic, and thermodynamic methods. The specific structures revealed the metal-pterin, metal-phenol, metal-indole ring, metal-iodinated phenol, phenol radical, and pterin radical. The present studies focused on the following points :
1) weak interactions involving aromatic rings in the proximity of a metal ion, 2) metal-aromatic ring interactions, 3) redox reactions and radical formation in the metal coordination sphece, and 4) construction of functional systems involving specific weak interactions. These points revealed how the chemical reactivity is controlled by the specific structure involving aromatic rings, which serves as a bases for understanding more complex systems containing metalloproteins. Intermolecular interactions between charged groups or aromatic side chains of metalloproteins control the structures and redox properties and thus the function of proteins such as electron transfer.