1999 Fiscal Year Final Research Report Summary
Integration system of diagnosis and hyperthermia by magnetite fine particles combined with cancer-targetability
| Project/Area Number |
09305055
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (A)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
生物・生体工学
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
KOBAYASHI Takeshi Nagoya University, Graduate School of Engineering, Department of Biotechnology, Professor, 工学研究科, 教授 (10043324)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SHINKAI Masashige Graduate School of Engineering, Department of Biotechnology, Assistant Professor, 工学研究科, 助手 (70262889)
YOSHIDA Jun Graduate School of Medicine, Department of Neurosurgery, Professor, 医学研究科, 教授 (40158449)
|
|---|
| Project Period (FY) |
1997 – 1999
|
| Keywords | Hyperthermia / Magnetic particles / Contrast medium / Induction heating / Cancer treatment / Immune induction / Liposome |
|---|
| Research Abstract |
We have developed "magnetite cationic liposomes" (MCL) as a new heating mediator for hyperthermia and also a new contrast medium for magnetic resonance imaging (MRI). MCL accumulated on solid glioma tissue in F344 rat specifically. MRI signals were changed by this accumulation and it was found that MCL is an effective contrast medium for MRI. The hyperthermic effect on solid glioma tissue grown subcutaneously in F344 rats was investigated. Complete tumor regression was observed in about 90% of the rats by three times of repeated heating. Furthermore, induction of antitumor immunity for T-9 rat glioma using MCL was observed. For tissue with very fast blood flow rate, it was difficult to increase the tissue temperature above 45℃ in induction heating. In this case, It was found that the combination of chemotherapy or gene therapy was effective.
|
