• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2000 Fiscal Year Final Research Report Summary

Immunological and molecular biological study of cytokine-network in periodontitis

Research Project

Project/Area Number 09470418
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field Conservative dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

ISHIKAWA Isao  Tokyo Medical and Dental University, Professor, 大学院・医歯学総合研究科, 教授 (10014151)

Co-Investigator(Kenkyū-buntansha) NAGASAWA Toshiyuki  Tokyo Medical and Dental University, Research associate, 大学院・医歯学総合研究科, 助手 (90262203)
NITTA Hiroshi  Tokyo Medical and Dental University, Research associate, 大学院・医歯学総合研究科, 助手 (70237767)
NOGUCHI Kazuyuki  Tokyo Medical and Dental University, Research associate, 大学院・医歯学総合研究科, 助手 (90218298)
HAYASHI Joichirou  Tokyo Medical and Dental University, Research associate, 大学院・医歯学総合研究科, 日本学術振興会特別研究員
Project Period (FY) 1997 – 2000
KeywordsIL-12 / IFN-g / periodontitis / Th1 / monocyte
Research Abstract

We have examined local and systematic function of cytokines against periodontopathic bacteria to clarify cytokine-network in periodontitis.
Helper T cells, which regulate immune responses, have been divided into Type1 helper T cell(Th1)and Type2 helper T cell(Th2). Th1 augments cell-mediated immune responses, and Th2 helps humoral immune responses. This difference is determined by cytokine production, for example, Th1 produces IFN-γ and IL-2, Th2 produces IL-4, IL-5, IL-6 and IL-10. The aim of our study in this year was to examine whether individual diversities exist on not in immune responses against periodontopathic bacteria, and how individual diversities affect the clinical status in periodontitis.
Periheral blood T cells produce IFN-γ by stimulation with periodontopathic bacteria. IFN-γ production varied among individuals. The production of IFN-γ was dependent on the ability of monocytes to produce IL-12.
As the severity of periodontitis was not different between IFN-γ high and low producer, we could not determine the susceptibility of periodontitis based on the polarization of Th1 or Th2, although immune response against periodontopathic bacteria varied among individuals.

  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] Kobayashi H, Nagasawa T, Aramaki M, Mahanonda M, Ishikawa I: "Individual diversities in interferon gamma production by human peripheral blood mononuclcer cells stimulated with periodontopathic bacteria"J Periodont Res. 35. 319-328 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小島丈尚、冨永由美子、石川烈: "初診時にActimobacillus actinomycetemcomitans, Porphyromonas gingivalisに対して高い血清IgG抗体価を示した歯周炎患者の長期的予後観察"日本歯周病学会誌. 41・4. 461-468 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Noguchi K, Iwasaki K, Shitashige M, Ishikawa I: "Prostaglandin E2 receptors of the EP2 and EP4 subtypes downregulate tumor necrosis factor-a induced intracellular adhesion molecule-1 expression in human gingival fibroblasts"J Periodont Res. 34. 478-485 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ono J, Nagasawa T, Aramaki M, Kobayashi H, Ishikawa I: "Periodontal status of a juvenile with selective IgA deficiency a case report"Joumal of the Intemational Academy of Periodontology. 1. 16-20 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Noguchi K, Iwasaki K, Endo H, Kondo H, Shitashige M, Ishikawa I: "Prostaglandin E2 and I2 downregulate rumor necrosis factor a-induced intercellular adhesion molecule-1 expression in human oral gingival epithelial cells"Oral Microbiol Immunol. 15. 299-304 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Noguchi K, Yanai M, Shitashige M, Nishihara T, Ishikawa I: "Cyclooxygenase-2 dependent prostaglandin production by peripheral blood monocyles stimulated with lipopolysaccharides isolated from periodontopathic bacteria"J Periodontol. 71. 1568-1575 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 長澤敏行、石川烈: "歯周病学最前線"奥田克爾、我孫子宜光、石川烈、岡田宏、古賀敏比呂、野口俊英、村山洋二. 354 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 林丈一郎、石川烈: "歯周病 新しい治療を求めて"岡田宏、石川烈、村山洋二. 530 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kobayashi H, Nagasawa T, Aramaki M, Mabanonda M, Ishikawa I.: "Individual diversities in interferon gamma production by human peripheral blood mononuclear cells stimulated with periodontopathic bacteria."J Periodonto Res.. 35. 319-328 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noguchi K, Iwasaki K, Shitashige M, Ishikawa I.: "Prostaglandon E2 receptors of the EP2 and EP4 subtypes downregulate tumor necrosis factor-a induced intracellular adhesion molecule expression in human gingival fibroblasts."J Periodontp Res. 34. 478-485 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ono J, Nagasawa T, Aramaki M, Kobayashi H, Ishikawa I.: "Periodontal status of a juvenile with selective IgA deficiency : a case report."Journal of the International Academy of Periodontplogy. 1. 16-20 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noguchi K, Iwasaki K, Endo H, Kondo H, Shitashige M, Ishikawa I.: "Prostaglandin E2 and I2 downregulate tumor necrosis factor-a induced intercellular adhesion molecule-1 expression in human oral gingival epithelial cells."Oral Microbiol Immunol. 15. 299-304 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noguchi K, Yanai M, Shitashige M, Nishihara T, Ishikawa I.: "Cyclooxygenase-2 dependent prostaglandin production by peripheral blood monocytes stimulated with lipopolysaccharides isolated from periodontopathic bacteria."J Periodontol. 71. 1568-1575 (2000)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2002-03-26  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi