1998 Fiscal Year Final Research Report Summary
Genetic polymorphisms related to alcohol metabolism and its effects on health
| Project/Area Number |
09670359
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Osaka University |
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Principal Investigator |
TAKESHITA Tatsuya Osaka Univ. Grad. Sch. Of Med. Assoc. Prof., 医学部, 助教授 (20150310)
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| Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Soichiro Osaka Univ. Grad. Sch. Of Med. Assist. Prof., 医学部, 助手 (70219567)
TAKEUCHI Toru Osaka Univ. Grad. Sch. Of Med. Lecturer, 医学部, 助教授 (00188161)
MORIMOTO Kanehisa Osaka Univ. Grad. Sch. Of Med. Prof., 医学部, 教授 (20143414)
EZOE Satoko Osaka Univ. Grad. Sch. Of Med. Assist. Prof., 医学部, 助手 (40232954)
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| Project Period (FY) |
1997 – 1998
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| Keywords | alcohol drinking / genetic polymorphism / aldehyde dehydrogenase / acetaldehyde / hemoglobin / biomarker |
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| Research Abstract |
Alcohol drinking have both harmful and preventive effects on health status. Ingested ethanol is converted in liver to very reactive metabolite, acetaldehyde, which can readily react with proteins and DNA, resulting in numerous responses. Those with the atypical ALDH2 genotype would be a good model to observe the effects of acetaldehyde since they have higher concentrations of acetaldehyde when they drink moderate amounts of alcohol. In the present studies, we have developed methods to sensitively measure acetaldehyde reversibly bound to hemoglobin (HbAA) in red blood cells in healthy subjects. We observed, among adult workers, a good correlations of the HbAA levels with the amounts of alcohol intake in the last two days, especially in the atypical ALDH2 genotype. Furthermore, we also found that this HbAA levels gradually increase when those with the atypical ALDH2 genotype drink moderate amounts of ethanol for 7 consecutive days. The results indicate that acetaldehyde would accumulate in the target tissues as reversible adducts to proteins in a similar way as in red blood cells. The HbAA levels would be one of useful biomarkers for evaluating and predicting consequences of alcohol drinking in each individual.
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[Publications] Itoh T., Matsumoto M. Nakamura M., Okada A., Shirahashi N., Hougaku H., Hashimoto H., Sakaguchi M., Handa N., Takeshita T., Morimoto K., Hori M.: "Effects of daily alcohol intake on the blood pressure differ depending on an individual's sensitivity to alcohol oriental flushing as a sign to stop drinking for health reasons"Journal of Hypertension. 15. 1211-1217 (1997)
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[Publications] Shizukuisi, S., Hayashi, N. Tamagawa, H., Hanioka, T., Maruyama, S., Takeshita, T., Morimoto, K.: "Lifestyle and periodontal health status of Japanese workers Annals of Periodontology"Annals of Periodontology. 3. 303-311 (1998)
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[Publications] Morimoto, K., Takeshita, T., Sakurai, C., and Mure, K.: "Comparative evaluation of environmental toxicants. Health effects of environmental toxicants derived from advanced technologies"National Institute of Radiological Sciences,Chiba, Lifestyle and health. In : Inaba, J. and Nakamura, Y. (eds.). 17-28 (1998)
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