1999 Fiscal Year Final Research Report Summary
PCR analysis herpes simplex virus brainstem and myelitis
| Project/Area Number |
09670679
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kurume University |
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Principal Investigator |
SHOJI Hiroshi Kurume University Professor, 医学部, 教授 (90122621)
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| Co-Investigator(Kenkyū-buntansha) |
EIZURU Yoshito Kagoshima University Faculty of Medicine, 医学部, 教授 (00041351)
KAJI Masahide Kurume University, 医学部, 助手 (70258408)
AYABE Mitsuhiro Kurume University, 医学部, 講師 (40232003)
HONDO Ryou Japan Veterinary University, 公衆衛生学, 教授 (20114639)
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| Project Period (FY) |
1997 – 1999
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| Keywords | encephalitis / brainstem / myelitis / herpes simlex virus / PCR / EIA |
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| Research Abstract |
We analyzed data from 39 patients with herpes simplex virus (HSV) infections of central nervous system (CNS) found in a 1993-1995 survey in Kyushu and Okinawa, Japan. Additionally nested polymerase chain reaction (PCR) analysis and enzyme immunosorbent assay (EIA) were conducted. Temporal lobe-limbic encephalitis was disseminated encephalomyelitis (ADEM) (3), meningitis (2), diffuse encephalitis (2), brainstem type (1) and other (5). There were also recurrent type (2 patients) and prolonged cases (11) hospitalized over 6 months in our study.
Since the induction of PCR , this study clarified that HSV CNS infections consisted of wider forms such as HSV related ADEM, brainstem encephalitis, myelitis and meningitis. PCR EIA analysis of HSV 1 and 2 differentiation included a few patients with HSV 2 infections. Also, 2 patients with non-herpetic acute limbic encephalitis were found. These data are compared with our previous study performed same regions in 1990-1992.
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