1998 Fiscal Year Final Research Report Summary
Chronomes (rhythms, chaos and disease and age trends) of heart rate variability in patients with coronary artery disease (CAD)
| Project/Area Number |
09670760
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
OTSUKA Kuniaki Tokyo Women's Medical University, School of Medicine, Professor, 医学部, 教授 (60038908)
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| Project Period (FY) |
1997 – 1998
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| Keywords | chronome / autonomic nervous activity / heart rate variability / rhythms / trends / fractal / chaos / complexity |
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| Research Abstract |
Heart rate variability (HRV) may reflect autonomic nervous activity. From 24-hour Holter ECG records on 66 male patients with CAD 30-88 years of age as well as on 339 healthy subjects (222M, 117F), 3-92 years of age, time-and frequency-domain and chaotic measures (correlation demension, CD, and complexity) of HRV were computed. Contrary to the results in health where most variables were found to statistically decrease with age, in the patients with CAD, only LF and CD decreased with age with statistical significance. The patients with CAD are found to differ from clinically healthy men of similar age in terms of SDNN, SDANN, TF, LF, LF/HF and CD.An assessment of chronomes of HRV may contribute to the diagnosis, prognosis and as putative guides to treatment timing.
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