1998 Fiscal Year Final Research Report Summary
PREVENTION OF DIABETES IN NON-OBESE DIABETIC (NOD) MICE BY IGF-I TREATMENT
| Project/Area Number |
09670813
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | EHIME UNIVERSITY SCHOOL OF MEDICINE, DEPARTMENT OF PEDIATRICS |
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Principal Investigator |
KIDA Kaichi EHIME UNIVERSITY SCHOOL OF MEDICINE,DEPARTMENT OF PEDIATRICS,PROFESSOR, 医学部, 教授 (80093409)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIDA Yasushi EHIME UNIVERSITY SCHOOL OF MEDICINE,DEPARTMENT OF PEDIATRICS,ASSOCIATE PROFESSOR, 医学部附属病院, 講師 (20221070)
ITO Takuo EHIME UNIVERSITY SCHOOL OF MEDICINE,DEPARTMENT OF PEDIATRICS,ASSOCIATE PROFESSOR, 医学部附属病院, 講師 (00243783)
KAINO Yukikazu EHIME UNIVERSITY SCHOOL OF MEDICINE,DEPARTMENT OF PEDIATRICS,ASSOCIATE PROFESSOR, 医学部附属病院, 講師 (00204313)
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| Project Period (FY) |
1997 – 1998
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| Keywords | insulin-dependent diabetes mellitus / Insulin-like growth factor I (IGF-I) / non-obese diabetic mice (NOD) mice / insulitis / prevention |
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| Research Abstract |
We reported previously that prophylactic short-term and high-dose IGF-I treatment at an early age could significantly delay the onset of diabetes in NOD mice, which are an animal model of human TDDM.This report describes the results of the IGF-I treatment in a NOD mouse colony with a higher incidence of overt diabetes. The IGF-T treatment prevented the development of the disease. The animals were treated with IGF-I 17.9 nmol/day at 28-41 days of age and 35.9 nmol/day at 42-69 days of age and observed up to 280 days of age. Three of 12 (25 %) IGF-I-treated animals developed diabetes compared with 8 of 11 (73 %) controls (P<0.05) . The severity of insulitis at the conclusion of the follow-up was less pronounced in nondiabetic treated animals than in nondiabetic controls. These data support the possibility that the IGF-I treatment may protect the pancreatic islets from destruction by diabetic autoimmunity in the NOD mice.
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