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2000 Fiscal Year Final Research Report Summary

Evaluation of newly developed heat liquid injector and its basic study

Research Project

Project/Area Number 09670950
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionWakayama Medical University

Principal Investigator

SATO Morio  Department of Radiology, Wakayama Medical University, Professor, 医学部, 教授 (50154109)

Co-Investigator(Kenkyū-buntansha) SUWA Kazuhiro  Department of Radiology, Wakayama Medical University, Assistant Professor, 医学部, 助手 (60187820)
KISHI Kazushi  Department of Radiology, Wakayama Medical University, Associate Professor, 医学部, 助教授 (70254547)
TERADA Masaki  Department of Radiology, Wakayama Medical University, Associate Professor, 医学部, 助教授 (80188680)
TAKEUCHI Taizo  Department of Radiology, Wakayama Medical University, Assistant Professor, 医学部, 助手 (10326374)
SHIRAI Shintaro  Department of Radiology, Wakayama Medical University, Assistant Professor, 医学部, 助手 (00192120)
Project Period (FY) 1997 – 2000
Keywordshepatoma / ethanol / heated ethanol / acetic acid / 抗癌剤溶液
Research Abstract

Percutaneous ethanol injection therapy (PEIT) has been widely accepted for the treatment of hepatocellular carcinoma (HCC). However, the limited volume of ethanol in one shot requires repeated injections to attain adequate results, restricting its application to less than 3 HCC nodules of less than 3 cm in diameter. We developed a device in which heated ethanol can be injected into tumor nodules safely and accurately under ultrasonic guidance using this device, we got the following results.
(1)When the temperature of ethanol injected reached 60℃, 70℃ the necrotic effects on the rat liver were markedly increased compared to those at room temperature.
(2)For injection of acetic acid, significant differences (P<0.05) were observed in volume of necrosis among groupes administered 5%, 20%, 30% and 50%. For 10% acetic acid, significant differences (P<0.05) were obseved in volume of necrosis among groups at 50℃, 70℃ and 100℃.
(3)It was shown that with injection of heated acetic acid, a strong necrotizing effect was obtained even at a low concentration.

  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] Morio Sato: "Current Status of Hepatocellular Carcinoma in Japan and Percatanecus Hot Ethanol Injection Therapy"Japanese Journal of Hyperthermic Oncology. 19. 9-16 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 佐藤守男: "肝細胞癌の現状と肝動脈塞栓術"化学療法の領域. 16. 32-36 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 中井資貴: "各種加温液体注入による肝組織障害能の比較-特に加温酢酸注入療法の可能性について-"和歌山医学会雑誌. 51. 417-423 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Morio Sato: "Current status of Hepatocellular Carcinoma in Japan and Percutaneous Hot Ethanol Injection Therapy"Japanese Journal of Hypertheramic Oncology. 19. 9-16 (2000)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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